A5029754036- Breast Cancer Treatment Studies
- Liquid Crystal Research Advancements
- HER2/EGFR in Cancer Research
- Lymphatic System and Diseases
- Breast Lesions and Carcinomas
- Analytical chemistry methods development
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Trace Elements in Health
- Vanadium and Halogenation Chemistry
- Diabetes and associated disorders
- Colorectal Cancer Surgical Treatments
- Multiple and Secondary Primary Cancers
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Molecular Biology Techniques and Applications
- Male Breast Health Studies
- Advanced Proteomics Techniques and Applications
- Cancer and Skin Lesions
- Monoclonal and Polyclonal Antibodies Research
- Nonlinear Dynamics and Pattern Formation
- PI3K/AKT/mTOR signaling in cancer
- Surfactants and Colloidal Systems
- Material Dynamics and Properties
The Maria Sklodowska-Curie National Research Institute of Oncology
2014-2024
Jagiellonian University
2022-2023
Radboud University Nijmegen
2023
John Paul II Catholic University of Lublin
2012-2018
Institute of Environmental Protection
2012-2018
Brain Tumour Charity
2018
AGH University of Krakow
2018
Yahoo (United Kingdom)
2015
Central Laboratory for Radiological Protection
2014
Maria Curie-Skłodowska University
2010-2013
Bladder urothelial carcinoma (BLCA) is the 10th most common cancer with a low survival rate and strong male bias. We studied field cancerization in BLCA using multi-sample- multi-tissue-per-patient protocol for sensitive detection of autosomal post-zygotic chromosomal alterations loss chromosome Y (LOY). analysed 277 samples histologically normal urothelium, 145 tumors 63 blood from 52 males 15 females, in-house adapted Mosaic Chromosomal Alterations (MoChA) pipeline. This approach allows...
Vemurafenib and dabrafenib are BRAF kinase inhibitors (BRAFi) used for the treatment of patients with melanoma carrying V600E mutation. However, cells develop resistance to both drugs when as monotherapy. Therefore, mechanisms drug investigated, new molecular targets sought that could completely inhibit progression. Since receptor-interacting protein (RIPK4) probably functions an oncogene in its structure is similar protein, we analyzed impact vemurafenib on RIPK4 melanomas. The silico study...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Adamczyk A, Niemiec J, Janecka et al. Original paperPrognostic value of PIK3CA mutation status, PTEN and androgen receptor expression for metastasis-free survival in HER2-positive breast cancer patients treated with trastuzumab adjuvant setting. Polish Journal Pathology. 2015;66(2):133-141. doi:10.5114/pjp.2015.53009. APA Adamczyk, A., Niemiec, J., Janecka, Harazin-Lechowska, Ambicka, & Grela-Wojewoda, A....
The alterations in the levels/activities of selected biomarkers for detecting kidney toxicity and levels some oxidative stress (OS) markers elements were studied male rats to evaluate biochemically degree damage, investigate role OS mechanism functional renal disorders, reveal potential function, assess mineral changes conditions a 12-week sodium metavanadate (SMV, 0.125 mg V/mL) exposure. results showed that is involved underlying development SMV-induced disturbances. They also suggest...
The aim of the study was to investigate if parameters associated with human epidermal growth factor receptor type 2 (HER2) status (HER2 gene copy number, HER2/CEP17 ratio or polysomy chromosome 17) are related various biological features potentially responsible for trastuzumab resistance (PTEN, IGF-1R, MUC4, EGFR, HER3, HER4, and mutation PIK3CA) as well their influence on survival HER2-positive breast cancer patients treated adjuvant chemotherapy trastuzumab.The investigated group consisted...
Intra-tumor heterogeneity (ITH) results from the coexistence of genetically distinct cancer cell (sub)populations, their phenotypic plasticity, and presence heterotypic components tumor microenvironment (TME). Here we addressed potential association between ITH revealed by mass spectrometry imaging (MSI) prognosis breast cancer. Tissue specimens resected 59 patients treated radically due to locally advanced HER2-positive invasive ductal carcinoma were included in study. After on-tissue...
Abstract Phase transitions of aqueous suspensions droplets smectogens have been studied using the collective Cotton-Mouton (CM) technique. Two compounds were examined: NPOOB and 8OCB. A statistical model (previously developed for nematogens) has adapted to describe CM effect in these systems. It was found that both phase changes architecture within cause distinct effect. An attempt made investigate theliquid crystalline germs created isotropic melts nematic smectic mesogens mixed with a...
The levels of elements in rats' organs the V–Mg interaction. A role DMT-1 tissue Fe homeostasis.
The extent to which the 12 week separate and combined administration of vanadium (as sodium metavanadate--SMV, 0.125 mg V per ml) magnesium sulphate--MS, 0.06 Mg affects bone mineral status micromorphology as well alkaline phosphatase (ALP) activity in femoral diaphysis (FD) was examined male rats. chemical composition SMV-exposed rats also investigated. SMV alone or combination with MS SMV-MS) reduced levels MgFD (by 21% 20%) PFD 12% 9%), lowered CaFD content 7% 10%), caused a rise FeFD...
Resistance to trastuzumab (which is a standard therapy for breast cancer patients with HER2 overexpression) associated higher risk of progression or death, and might be related activation signalling cascades (PI3K/AKT/mTOR, Ras/Raf/MAPK) decreased level their inhibitors.Formalin-fixed paraffin-embedded tumour specimens from 118 HER2-overexpressing treated radical local in adjuvant setting were used the assessment of: (1) PIK3CA gene mutations (p.H1047R p.E545K) by qPCR, (2) expression Ki-67,...
On 24th of February 2022, Ukrainian cancer patients had to face a new war. Here we describe an experience the Maria Sklodowska-Curie National Research Institute Oncology Branch Krakow in providing care for refugees during initial 6 weeks We present patients' characteristic, point out main challenges and share initiatives undertaken.For this cross-sectional analysis, have gathered demographic clinical data together with date crossing Polish-Ukrainian border 112 who their first-time oncology...
AMA Adamczyk A, Niemiec J, Ambicka et al. Expression of ER/PR/HER2, basal markers and adhesion molecules in primary breast cancer lymph nodes metastases: a comparative immunohistochemical analysis. Polish Journal Pathology. 2012;63(4):228-234. doi:10.5114/pjp.2012.32769. APA Adamczyk, A., Niemiec, J., Ambicka, Małecki, K., Wysocki, W., & Mituś, J. (2012). Pathology, 63(4), 228-234. https://doi.org/10.5114/pjp.2012.32769 Chicago Agnieszka, Joanna Aleksandra Krzysztof Wojciech H. Jerzy Janusz...
Podoplanin, expressed in the lymphatic but not blood vessel endothelium, is widely used as a specific marker for endothelial cells and lymphangiogenesis. The relation between density breast cancer subtype or expression of basal markers has yet been investigated. We assessed (LVD), density, podoplanin stromal cancer-associated fibroblasts, 156 invasive ductal cancers (T≥1, N≥1, M0). Afterwards, we relationship above-mentioned parameters (i) (luminal vs. HER2 triple negative), (ii) tumor grade...
It has been suggested that the metastatic potential of neoplastic cells can be predicted on basis their biological features, including expression proteins involved in epithelial to mesenchymal transition (EMT). Therefore, purpose this work was (1) evaluate EMT markers: ZEB2, vimentin, N-cadherin, TWIST, PTEN, survivin, E-cadherin, Ki-67 and GLUT-1, (2) assess mutation status two genes: PIK3CA KRAS, (3) investigate relationships between studied biomarkers clinicopathological factors...