Background:The broad spectrum of oxidative damage DNA biomarkers: urinary excretion 8-oxodG (8-oxo-7,8-dihydro-2'-deoxyguanosine), 8-oxoGua (8-oxo-7,8-dihydroguanine) as well the level in leukocytes, was analyzed cancer patients and healthy subjects.Material/Methods:222 134 volunteers were included analysis, using methodologies which involve HPLC (high-performance liquid chromatography) prepurification followed by gas chromatography with isotope dilution mass spectrometry detection...

The IN-PATSAT32 and QLQ-INFO25 are questionnaires which can be applied to assess improve communication with cancer patients, as well for research clinical trials aimed at assessing patients' satisfaction perception of the information received from nurses other healthcare providers. Given recently passed "Polish oncological network" act law, issue patient its regular assessment is finally acknowledged in socioeconomic cultural context Poland. aim this study was validate EORTC quality...

Abstract Purpose HPV is involved in the development of some head and neck squamous-cell carcinomas (HNSCC). It was suggested that only transcriptionally active virus can induce carcinogenesis, therefore, aim our study to analyze frequency infection, type, its prognostic role HNSCC patients. Methods Status infection assessed for 155 patients based on p16 expression DNA presence. Univariate multivariate analyses with Cox proportional regression model were performed select independent factors....

Presentation of long-term results radiation treatment in patients with T1 glottic cancer and evaluation prognostic factors. We performed a retrospective analysis group 569 squamous cell carcinoma treated radiotherapy at the Center Oncology Cracow between 1977 2007. In all, 503 (88%) presented T1a stage disease 66 (12%) T1b. Anterior commissure infiltration was present 179 (31%) patients. Average hemoglobin level prior to therapy 13.9 g/dl. Using body mass index (BMI), 114 (20%) were...

The purpose of the study was to analyse influence HPV infection on outcome a randomized clinical trial conventional (CF) versus 7-days-a-week postoperative radiotherapy (p-CAIR) for squamous cell cancer head and neck (SCCHN). Between 2001 2004, 279 patients with high-risk SCC larynx or oral cavity/oropharynx were receive 63 Gy in fractions 1.8 given 5 days week 7 (Radiother Oncol 87:155–163, 2008). presence DNA 131 archival paraffin blocks assessed multiplex quantitative real-time PCR using...

The aim of the study was to compare prognostic potential PIK3CA mutations and expression proteins involved in or regulate EGFR/PI3K/Akt/mTOR signaling HPV16 positive HPV negative head neck squamous cell carcinoma (HNSCC) patients. (EGFR, Akt, pAkt(Ser473), pAkt(Thr308), mTOR, PTEN, pPTEN, APOBEC3B) were assessed immunohistochemically (p.E542K, p.E545K, p.H1047R) by qPCR. Significantly more tumors (89.29%) with low EGFR found as compared ones (58.82%). detected 7.14% 2.5% cancers. In patients...

On 24th of February 2022, Ukrainian cancer patients had to face a new war. Here we describe an experience the Maria Sklodowska-Curie National Research Institute Oncology Branch Krakow in providing care for refugees during initial 6 weeks We present patients' characteristic, point out main challenges and share initiatives undertaken.For this cross-sectional analysis, have gathered demographic clinical data together with date crossing Polish-Ukrainian border 112 who their first-time oncology...

To determine the relationship between interval from surgery to initiation of radiation therapy (ISRT) and prognostic factors, such as age, performance status, tumour location, extent surgical resection histology in patients with malignant gliomas.From 1995 2005, 308 adults supratentorial gliomas (198 glioblastomas, 110 anaplastic astrocytomas) received postoperative radiotherapy radical intent. A total dose 60 Gy 30 fractions 6 weeks was delivered. ISRT varied 15 124 days, median time 37 it...

Podoplanin, expressed in the lymphatic but not blood vessel endothelium, is widely used as a specific marker for endothelial cells and lymphangiogenesis. The relation between density breast cancer subtype or expression of basal markers has yet been investigated. We assessed (LVD), density, podoplanin stromal cancer-associated fibroblasts, 156 invasive ductal cancers (T≥1, N≥1, M0). Afterwards, we relationship above-mentioned parameters (i) (luminal vs. HER2 triple negative), (ii) tumor grade...

Approximately 60 % of patients with locally advanced laryngeal cancer (LALC) treated primarily surgery require adjuvant radiotherapy. In the available literature predominate series were pathologically confirmed node-positive status. Subgroups pN0 LALC are scarce. The aim study is to evaluate efficacy postoperative radiotherapy in pathological stage T3-4N0M0 and identification prognostic factors this group. Between 1975 2005, 138 squamous pT3-4N0 irradiated postoperatively. Primary surgical...

To evaluate the impact of HPV16 load (VL—the number virus genome copies per cell) and P16 expression on prognosis patients with squamous cell carcinomas (SCCs) head neck (HN). presence was assessed in group 109 HNSCCs by quantitative polymerase chain reaction (qPCR). VL (assessed qPCR) (evaluated immunohistochemistry) were analysed only subgroup HPV16-positive tumours. These features correlated 5-year overall survival (OS) disease-free (DFS). infection found 36 tumours (33.0%)....

Trastuzumab-induced cardiotoxicity (TIC) can lead to early treatment discontinuation. The aim of this study was evaluate: N-terminal brain natriuretic peptide (NT-proBNP), creatine kinase-MB (CK-MB), myoglobin, and selected biochemical clinical factors as predictors TIC. One hundred thirty patients with HER2-positive BC receiving adjuvant trastuzumab therapy (TT) were enrolled. Measurement cardiac markers tests well echocardiography performed prior TT initiation every three months...

Metaplastic breast cancer (BC‑Mp), which includes a range of epithelial and mixed epithelial‑mesenchymal tumours, are rare malignancies with an unfavourable prognosis. The limited literature on BC‑Mp focuses mainly retrospective data for radically treated patients. Notably absent studies dedicated to the palliative treatment distant metastases. present study investigated modalities prognosis in multi‑centre cohort 31 female participants diagnosed metastatic BC‑Mp, including 7 patients <em>de...

Background Primary neuroendocrine neoplasms of the breast (Br-NENs) are rare. The classification has been updated in recent years making interpretation data published challenging. It is unclear whether differentiation associated with poorer prognosis and what treatment approaches should be applied. Methods database for cancer patients treated between 2009 2022 at Maria Sklodowska-Curie National Research Institute Oncology Branch Krakow was explored to search Br-NENs. Patients’ medical...

Background: The differences between primary and metastatic tumor cells might be important for treatment selection prognostication. Materials & methods: Expression of ER, PR, HER2, CK5/6, EGFR, Ki-67, Ep-CAM, P-cadherin, CD24, CD44, ALDH was assessed immunohistochemically in (T) corresponding synchronous nodal metastases (LNM) 156 invasive ductal breast cancer patients (T ≥1, N M0). Results: Independent negative prognostic factors disease-free survival were pN3, immunopositivity LNM,...

Recently, the prognosis of patients with HER2‑positive breast cancer (BC) has improved significantly owing to use combined treatment modalities. However, systemic is as-sociated increased risk cardiotoxicity.We aimed assess subclinical cardiac alterations during final stage adjuvant com-bined therapy, that is, trastuzumab therapy (TT), as potential predictors late complications in BC.We enrolled 251 BC treated a radical local chemotherapy (anthracyclines or anthracyclines + taxanes), and...

Infection with HPV16 in cancers of the oral cavity (OCSCC) and oropharynx (OPSCC) is, today, an important etiological prognostic factor. Patients HPV-positive OPSCC have a better prognosis than uninfected patients. However, over 40% these patients, cancer progression is noticed. Their identification particularly due to ongoing clinical trials regarding possibility de-escalation anticancer treatment patients OPSCC. Some studies suggest that there differentiate HPV16-positive by STING...