A5001520565- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Chemotherapy-induced cardiotoxicity and mitigation
- Systemic Sclerosis and Related Diseases
- Renal cell carcinoma treatment
- Breast Lesions and Carcinomas
- Venous Thromboembolism Diagnosis and Management
- PI3K/AKT/mTOR signaling in cancer
- Melanoma and MAPK Pathways
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Vasculitis and related conditions
- Brain Metastases and Treatment
- Patient-Provider Communication in Healthcare
- Economic and Financial Impacts of Cancer
- Peripheral Artery Disease Management
- Monoclonal and Polyclonal Antibodies Research
- Bladder and Urothelial Cancer Treatments
- Chronic Lymphocytic Leukemia Research
Jagiellonian University
2012-2025
The Maria Sklodowska-Curie National Research Institute of Oncology
2018-2025
University College of Tourism and Ecology
2023-2025
York District Hospital
2024
National Institute of Oncology
2023-2024
Centrum Onkologii
2018
Immune checkpoint inhibitors have improved the treatment of metastatic renal cell carcinoma (RCC), with combination nivolumab (NIVO) and ipilimumab (IPI) showing promising results. However, not all patients benefit from these therapies, emphasizing need for reliable, easily assessable biomarkers. This multicenter study involved 116 advanced RCC treated NIVO + IPI across nine oncology centers in Poland. Blood markers such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR),...
The IN-PATSAT32 and QLQ-INFO25 are questionnaires which can be applied to assess improve communication with cancer patients, as well for research clinical trials aimed at assessing patients' satisfaction perception of the information received from nurses other healthcare providers. Given recently passed "Polish oncological network" act law, issue patient its regular assessment is finally acknowledged in socioeconomic cultural context Poland. aim this study was validate EORTC quality...
Hepatic visceral crisis (VC), characterized by a rapid total bilirubin increase with disease progression, poses life-threatening risk in advanced breast cancer (ABC). International consensus guidelines define VC and touch on impending (IVC). Limited data exist systemic treatments for hepatic VC/IVC. This study explores the safety efficacy of cisplatin monotherapy patients Human Epidermal Growth Factor Receptor 2- negative (BC) IVC/VC.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with variable clinical manifestation, potentially leading to death. Importantly, patients SLE have an increased risk of neoplastic disorders. Thus, this study aimed comprehensively evaluate the and laboratory characteristics or without malignancy.
Abstract Background Immune checkpoint inhibitors (ICIs) have been employed in the adjuvant and metastatic setting of renal cell carcinoma (RCC) treatment. Among ICIs, combined immunotherapy has highest risk for immune-related adverse events (irAEs). We aimed to document incidence irAEs RCC patients treated with nivolumab ipilimumab as data from European population remain limited. Materials methods analysed 88 + between May 2022 June 2024 across six high-volume oncology units Poland. reviewed...
The type of silhouette and quantity fat tissue are correlated with hormonal imbalance which plays a substantial role in breast carcinogenesis. goal the study was to investigate association between various anthropometric characteristics cancer risk.Detailed assessment conducted on 487 women whom 193 had diagnosed were consecutive patients Oncology Center, Cracow, Poland 2002 2004. Measurements divided into four categories: overall body size (body mass index [BMI], waist circumference [WC],...
Patients with systemic sclerosis experience endothelial dysfunction and damage even in the absence of clinical manifestations.To evaluate various methods for assessing function their applicability to practice.Forty-two patients (7 men 35 women) 36 controls (11 25 matched age, sex, body mass index, smoking habit, comorbidities were enrolled study. We assessed each participant typical risk factors cardiovascular diseases measured serum levels vascular cell adhesion molecule-1 (VCAM-1)...
Granulomatosis with polyangiitis (GPA) is a rare granulomatous vasculitis affecting small- and medium-sized blood vessels. In optimally treated patients long-standing disease, the common cause of death atherosclerosis even in absence typical risk factors. To evaluate endothelial dysfunction GPA patients. 44 (21 men 23 women) diagnosed 53 controls matched for age, sex, BMI factors cardiovascular diseases (22 31 were enrolled study. We measured each participant's serum levels vascular cell...
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of vasculitis associated asthma and eosinophilia. Endothelial dysfunction has been well documented in other types but not EGPA. Thirty patients (10 men 20 women) diagnosed EGPA remaining remission, 58 controls (24 34 matched for age, sex, body mass index, were enrolled the study. We assessed each participants typical risk factors cardiovascular diseases measured serum levels vascular cell adhesion molecule-1 (VCAM-1),...
Immune checkpoint inhibitors have significantly improved the prognosis of melanoma patients. However, these therapies may trigger unexpected immune-related adverse events (irAEs), which are challenging in making proper diagnosis and providing treatment. Hematological toxicities possible irAEs, but were poorly evaluated clinical trials treatment recommendations this specific complications limited. We present a stage IV patient who developed an extremely rare toxicity - hemophagocytic...
Trastuzumab-induced cardiotoxicity (TIC) can lead to early treatment discontinuation. The aim of this study was evaluate: N-terminal brain natriuretic peptide (NT-proBNP), creatine kinase-MB (CK-MB), myoglobin, and selected biochemical clinical factors as predictors TIC. One hundred thirty patients with HER2-positive BC receiving adjuvant trastuzumab therapy (TT) were enrolled. Measurement cardiac markers tests well echocardiography performed prior TT initiation every three months...
Metaplastic breast cancer (BC‑Mp), which includes a range of epithelial and mixed epithelial‑mesenchymal tumours, are rare malignancies with an unfavourable prognosis. The limited literature on BC‑Mp focuses mainly retrospective data for radically treated patients. Notably absent studies dedicated to the palliative treatment distant metastases. present study investigated modalities prognosis in multi‑centre cohort 31 female participants diagnosed metastatic BC‑Mp, including 7 patients <em>de...
Background Primary neuroendocrine neoplasms of the breast (Br-NENs) are rare. The classification has been updated in recent years making interpretation data published challenging. It is unclear whether differentiation associated with poorer prognosis and what treatment approaches should be applied. Methods database for cancer patients treated between 2009 2022 at Maria Sklodowska-Curie National Research Institute Oncology Branch Krakow was explored to search Br-NENs. Patients’ medical...
Combined immunotherapy with nivolumab and ipilimumab has become the standard first-line therapy regimen for intermediate poor-risk patients renal cell carcinoma (RCC) specifically those clear (ccRCC) sarcomatous components.However, in pivotal CheckMate 214
Abstract Recent reports have demonstrated that endothelial injury is critical in the pathogenesis of systemic sclerosis (SSc) and associated with increased levels circulating inflammatory biomarkers. This study aims to analyze serum concentrations selected cytokines evaluate their relationship SSc clinics long-term course disease. included 43 patients 24 matched healthy controls. In both groups, we measured related response, such as tumor necrosis factor (TNF)α, interferon (IFN)γ,...