A5076133985- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Sclerosis and Related Diseases
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Sarcoidosis and Beryllium Toxicity Research
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Renal Diseases and Glomerulopathies
- Liver Diseases and Immunity
- Asthma and respiratory diseases
- Atrial Fibrillation Management and Outcomes
- Acute Myocardial Infarction Research
- Nasolacrimal Duct Obstruction Treatments
- Peripheral Neuropathies and Disorders
- Cardiomyopathy and Myosin Studies
- Spondyloarthritis Studies and Treatments
- Vascular Malformations and Hemangiomas
- Dermatologic Treatments and Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Congenital Diaphragmatic Hernia Studies
- Ultrasound in Clinical Applications
- Cardiac Health and Mental Health
- Cancer and Skin Lesions
University School of Physical Education in Kraków
2024
Jagiellonian University
2020-2024
Krakow Cardiovascular Research Institute
2023
Abstract Background Lupus nephritis (LN) manifests systemic lupus erythematosus (SLE) and is characterized by various clinical laboratory features. This study aimed to comprehensively evaluate the characteristics of LN patients according time diagnosis: early-onset (LN diagnosed within one year from SLE diagnosis) vs. delayed-onset more than after diagnosis). Methods We conducted a retrospective analysis medical records all treated at University Hospital in Kraków, Poland, 2012 2022....
Natural killer (NK) cells plays a pivotal role in the control of viral infections, and their function depend on balance between activating inhibitory receptors. The immune dysregulation observed COVID-19 patients was previously associated with downregulation NK cell numbers function, yet mechanism inhibition functions interplay infected remain largely unknown. In this study we show that SARS-CoV-2 infection airway epithelial can directly influence phenotype microenvironment. were co-cultured...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with variable clinical manifestation, potentially leading to death. Importantly, patients SLE have an increased risk of neoplastic disorders. Thus, this study aimed comprehensively evaluate the and laboratory characteristics or without malignancy.
Background: Lupus nephritis (LN) is an inflammation of the kidneys that related to systemic lupus erythematosus (SLE). This study aimed evaluate differences in clinical and laboratory characteristics between LN non-LN SLE patients. Methods: We conducted a retrospective analysis medical records collected from patients treated at University Hospital Kraków, Poland, 2012 2022. All met 2019 European League Against Rheumatism American College Rheumatology (EULAR/ACR) criteria for SLE. Results:...
Background.Certain mediators, such as soluble growth factors and cytokines, among others, are implicated in the immunopathogenesis of systemic sclerosis (SSc).Objectives.This study aimed to examine association between serum levels vascular endothelial factor (VEGF), interleukin-8 (IL-8), interferon alpha (IFN-α), basic fibroblast (bFGF) clinical presentation course SSc. Materials methods.This longitudinal, observational included 43 patients with SSc 24 healthy subjects.Serum concentrations...
Abstract Recent reports have demonstrated that endothelial injury is critical in the pathogenesis of systemic sclerosis (SSc) and associated with increased levels circulating inflammatory biomarkers. This study aims to analyze serum concentrations selected cytokines evaluate their relationship SSc clinics long-term course disease. included 43 patients 24 matched healthy controls. In both groups, we measured related response, such as tumor necrosis factor (TNF)α, interferon (IFN)γ,...
Background/Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the abnormal activation of autoreactive T and B cells, autoantibody production, complement activation, immune-complex deposition, resulting in tissue damage. However, data on immunologic disturbances SLE, particularly regarding flares, are scarce. Methods: We investigated 35 patients with SLE: 12 (34.3%) exacerbation (SLE activity index [SLEDAI] ≥ 5 points) 23 (65.7%) remission (SLEDAI <...
Tumor necrosis factor (TNF)-α is a proinflammatory cytokine that plays an important role in the pathogenesis of autoimmune diseases. The aim study was to establish association between TNF-α promoter variability and systemic sclerosis (SSc). included 43 SSc patients 74 controls. Four single nucleotide polymorphisms (rs361525, rs1800629, rs1799724, rs1799964) located at TNFA gene were genotyped using commercially available TaqMan allelic discrimination assays with real-time PCR. rs1799724...
Despite an increase in the proportion of nonagenarians demographic structure, there is still a paucity data on utilization and outcome percutaneous coronary interventions (PCIs) this population. Also, very old patients are under-represented randomized clinical trials their treatment emerging challenge. Thus, we sought to compare patient profiles periprocedural outcomes PCI younger than 90 years.Data were based Polish National Registry (ORPKI). A total 651 080 consecutive with stable angina...
Abstract Background Lung ultrasound (LUS) is an increasingly popular imaging method in clinical practice. It became particularly important during the COVID-19 pandemic due to its mobility and ease of use compared high-resolution computed tomography (HRCT). The objective this study was assess value LUS quantifying degree lung involvement discrimination lesion types course pneumonia as HRCT analyzed by artificial intelligence (AI). Methods This a prospective observational including adult...
Background: Percutaneous coronary intervention (PCI) is an effective method for the treatment ofcoronary artery disease (CAD) that allows a short hospital stay and fast recovery. It has been shown PCI predictor of nonattendance at cardiac rehabilitation correlates with poor adherence to lifestyle changes. Aims: The study was conducted evaluate influence education offered during PCI‑related hospitalization on knowledge, awareness, prevalence self‑reported risk factors CAD. Methods: We...
Asthma heterogeneity complicates the search for targeted treatment against airway inflammation and remodeling. We sought to investigate relations between eosinophilic inflammation, a phenotypic feature frequent in severe asthma, bronchial epithelial transcriptome, functional structural measures of compared gene expression, spirometry, cross-sectional geometry (computed tomography), reticular basement membrane thickness (histology), blood bronchoalveolar lavage (BAL) cytokines n = 40 moderate...
Objectives Rheumatic diseases were previously associated with increased incidence of monoclonal gammopathy (MG) and its malignant transformation. The present study aimed to investigate the prevalence, transformation risk, clinical correlates prognostic impact MG in SLE. Methods A retrospective cohort based on medical records n=1039 patients SLE fulfilling 1997 American College Rheumatology (ACR), 2019 European Alliance Associations for (EULAR)/ACR and/or 2012 Systemic Lupus International...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kosałka-Węgiel J, Milewski M, Siwiec A, Strach Ochrem B, Korkosz M. Severe hypereosinophilic syndrome successfully treated with a monoclonal antibody against interleukin 5 receptor α – benralizumab. Central European Journal of Immunology. 2021. doi:10.5114/ceji.2021.108259. APA Kosałka-Węgiel, J., Milewski, M., Siwiec, A., Strach, Ochrem, B., & Korkosz, (2021). https://doi.org/10.5114/ceji.2021.108259 Chicago...
Sarcoidosis is a multisystem inflammatory granulomatous disease of unknown cause that most commonly affects lungs and lymph nodes, with frequent yet asymptomatic cardiac involvement. The epidemiologically associated cardiovascular risk suggests an underlying prothrombotic state endothelial dysfunction, currently understudied in the available literature. Therefore, we aimed to investigate plasma properties together selected echocardiographic laboratory biomarkers injury disease. N = 53...
Abstract Background Heterogeneity of asthma complicates search for targeted treatment against airway hyperresponsiveness and remodeling. We conducted a systems biology approach study to establish differential co-expression genes (DCG) in eosinophilic non-eosinophilic patients infer their role the disease. Materials Methods N = 40 Caucasian adult moderate severe non-smoking (half with asthma) undergone bronchial brush biopsy sampling mRNA expression using hybridization cDNA microarray....
Abstract Objective: Sarcoidosis is a multisystem inflammatory granulomatous disease of unknown cause that most commonly affects lungs and lymph nodes, with frequent yet asymptomatic cardiac involvement. The epidemiologically associated cardiovascular risk suggests an underlying prothrombotic state endothelial dysfunction, currently understudied in the available literature. Therefore, we aimed to investigate plasma properties together selected echocardiographic laboratory biomarkers injury...