A5065094545- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Urticaria and Related Conditions
- Systemic Sclerosis and Related Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Atherosclerosis and Cardiovascular Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood Coagulation and Thrombosis Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Blood disorders and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lipoproteins and Cardiovascular Health
- Hemophilia Treatment and Research
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- Inflammatory mediators and NSAID effects
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Atrial Fibrillation Management and Outcomes
- Eosinophilic Esophagitis
- Cell Adhesion Molecules Research
Jagiellonian University
2015-2024
University School of Physical Education in Kraków
1995-2022
Medical University of Lodz
2007-2022
Regeneron (United States)
2022
AstraZeneca (Brazil)
2022
Triangle
2022
Bristol-Myers Squibb (Switzerland)
2022
University of Opole
2020
University of Łódź
2014-2019
Collegium Medicum in Bydgoszcz
2007-2018
Background —The mechanism of the antithrombotic action statins is unclear. The aim this study was to evaluate effects simvastatin on coagulation process at sites microvascular injury. Methods and Results —Tissue factor–initiated assessed in blood samples collected every 30 seconds from bleeding-time wounds 17 patients who had advanced coronary artery disease total cholesterol levels 224.6±11.8 mg/dL (mean±SEM). Quantitative Western blotting for time courses fibrinogen depletion activation...
The mechanism underlying decreased risk for myocardial infarction in carriers of the Leu34 polymorphism factor (F) XIII A-subunit is unclear. Given that acetylation fibrinogen by aspirin can alter its clotting properties and presence fibrin stimulates thrombin-mediated activation FXIII, we have tested hypothesis treatment with differentially modulates influence FXIII Val34Leu on vivo.The rates disappearance FXIIIA chain appearance activated form (FXIIIAa) sequential 30-second blood samples...
Abstract Background One of the most important areas Raman medical diagnostics is identification and characterization cancerous noncancerous tissues. The methods based on scattering has shown significant potential for probing human breast tissue to provide valuable information early diagnosis cancer. A vibrational fingerprint from biological provides which can be used identify, characterize discriminate structures in tissue, both normal environment. Results paper reviews recent progress...
Objective. Churg–Strauss syndrome (CSS) is a rare systemic vasculitis associated with eosinophilia and asthma. We assessed the local immune response in airways of CSS patients different activity disease.
The applications of spectroscopic methods in cancer detection open new possibilities early stage diagnostics. Raman spectroscopy and imaging represent novel rapidly developing tools diagnosis. In the study described this paper has been employed to examine noncancerous cancerous human breast tissues same patient. most significant differences between were found regions characteristic for vibrations carotenoids, lipids proteins. Particular attention was paid role played by unsaturated fatty...
Background Mechanisms by which the Pl A2 (Leu33Pro) polymorphism of β 3 integrins could lead to an increased risk for coronary events are unclear. This study was designed examine effect this on blood coagulation. Methods and Results In normal subjects (12 with A1A1 , 9 A1A2 A2A2 ), we evaluated activation prothrombin, factor V, XIII fibrinogen removal quantitative immunoblotting; thrombin-antithrombin III complex generation using ELISA; levels fibrinopeptide A B high-performance liquid...
Impaired function of regulatory T-cells (Treg) leads to a failure in immune tolerance and triggers autoimmunity. We analyzed whether the deficiency Treg systemic lupus erythematosus (SLE) is accompanied by an increase effector T-cell responses. studied frequencies IL-17A (Th17) IFNg (Th1) producing CD4(+) flow cytometric detection intracellular cytokines PMA/ionomycin stimulated blood lymphocytes from seven patients with active SLE, eight SLE remission, 11 healthy controls. Circulating were...
Background: Cardiac involvement in Churg-Strauss syndrome (CSS) is not uncommon, but its frequency varies widely and may depend on the activity of disease. Therefore, cardiac CSS patients clinical remission was assessed present study. Methods Results: In 20 sex- age-matched healthy controls, an ECG stress test, echocardiography, 24-h Holter monitoring were performed, together with magnetic resonance imaging (cMRI). 90% (18/20) patients. Left ventricular ejection fraction (LVEF) average lower...
Abstract Introduction Mortality in systemic lupus erythematosus (SLE) patients is influenced by an increased occurrence of severe cardiovascular complications. Statins have been proven to protect a wide spectrum SLE from these This study was conducted determine the possible efficacy atorvastatin as assessed multi-detector computed tomography (MDCT)-based coronary calcium scoring and single photon emission (SPECT) myocardium. Methods Sixty stable clinical conditions were randomized receive...
Objective A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) might contribute to a better identification antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted ascertain value aPS/PT for APS diagnosis. Methods In study (eight centres, seven countries), clinical/laboratory data retrospectively...