A5003153211- Pregnancy and Medication Impact
- Systemic Lupus Erythematosus Research
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- Platelet Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Folate and B Vitamins Research
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Pharmaceutical studies and practices
- Breastfeeding Practices and Influences
- Eosinophilic Esophagitis
- Pharmacological Effects and Toxicity Studies
- Monoclonal and Polyclonal Antibodies Research
- Parvovirus B19 Infection Studies
- Immunodeficiency and Autoimmune Disorders
- Gestational Diabetes Research and Management
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Prenatal Substance Exposure Effects
- Urticaria and Related Conditions
- Sleep and related disorders
- Autoimmune and Inflammatory Disorders Research
- Blood Coagulation and Thrombosis Mechanisms
National Center For Child Health and Development
2016-2025
Saitama Medical University
2024
Japan Society
2018
Mount Sinai Hospital
2016
University of Toronto
2016
Aalborg University Hospital
2016
Herlev Hospital
2016
Institut Gustave Roussy
2016
Centre Hospitalier Universitaire de Bordeaux
2016
Peking Union Medical College Hospital
2016
The partial amino acid sequence of the NH2 terminus a factor named human B-cell differentiation or stimulatory 2 (BSF-2) has been determined. Antibodies raised against synthetic peptide corresponding to residues 1-13 NH2-terminal specifically react with BSF-2 generated by T-cell line and phytohemagglutinin-stimulated normal T cells. Furthermore, antipeptide antibodies BSF-2-like produced cardiac myxoma as well uterine cervical carcinoma results show that functions in vivo suggest...
To assess the effects of tocilizumab on pregnancy outcomes in Japanese patients with rheumatic disease.
The aim of this study was to update the Japan College Rheumatology (JCR) clinical practice guidelines (CPG) for management rheumatoid arthritis (RA; JCR CPG RA) according recent changes in medical environment Japan. This article is a digest version guidance.We used Grading Recommendations, Assessment, Development, and Evaluation method 2014 RA. A consensus formed by panel members.We identified 36 important questions regarding drug treatment developed corresponding recommendations included...
ABSTRACT Aim Uncontrolled chronic inflammatory diseases (CIDs) before, during, and after pregnancy, as well some CID medications, can increase the risk of impaired fertility in addition to adverse maternal/pregnancy outcomes women childbearing age. We report pregnancy from prospectively reported pregnancies Japanese treated with certolizumab pegol (CZP). Methods Data July 2001 November 2020 on CZP‐exposed CZP Pharmacovigilance safety database were reviewed. Pregnancy analyzed included live...
Objective A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) might contribute to a better identification antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted ascertain value aPS/PT for APS diagnosis. Methods In study (eight centres, seven countries), clinical/laboratory data retrospectively...
Background Amlodipine is used for the treatment of hypertension, but reports on its use in early pregnancy are limited. Methods and Results In present study, we recruited 231 women with chronic including those who received amlodipine or other antihypertensives during pregnancy, investigated frequencies morphologic abnormalities their offspring. Specifically, evaluated 48 neonates exposed to first trimester (amlodipine group, Group A), 54 than (other antihypertensive O), 129 not...
Recurrent herpes simplex (RHS) is a disease caused by reactivation of the virus. Patients with RHS are treated anti-herpes virus medication. Amenamevir one such medication used for in Japan and administered as patient-initiated therapy (PIT); this involves initiation at discretion patient, based on early symptoms. However, there insufficient data transfer amenamevir into breast milk among breastfeeding patients RHS. This study aims to assess evaluate infant's risk drug exposure. single-arm,...
Abstract To determine the optimal timing for influenza vaccination in pregnant women, we measured alterations types 1 and 2 T helper cell (Th1/Th2) balance during pregnancy, monitored specific immunity to inoculated antigens after with inactivated vaccine, evaluated relevance of Th1/Th2 ratio immune responses vaccination, maintenance high antibody titers until delivery transplacental transfer rate. No significant were noted 65% women among whom was lower than 9.9% first trimester. In those...
Reports of hypothyroidism after hysterosalpingography (HSG) using lipiodol are emerging. The present study was designed to investigate the changes in serum iodine concentration (SIC), urinary concentration/creatinine excretion (UI/Cr), and thyroid function before HSG lipiodol.The prospective observation included 22 infertile euthyroid women with no previous history disease. All underwent between April 2007 August 2008 at our institution. We examined SIC, UI/Cr, HSG, 4, 8, 12, 24 weeks, 9-12...
Abstract Given the paucity of safety data on fluoroquinolone antibiotics in pregnancy, a prospective observational cohort study was conducted pregnant women who sought help and advice drug use at two teratology information institutes Japan. The primary endpoint incidence major congenital anomalies. population included exposed to (i) fluoroquinolones (fluoroquinolone group), (ii) β‐lactams (infectious control or (iii) other agents considered be nonteratogenic humans (nonteratogenic group)...
To determine the association of HLA antigens with SLE and clinical findings disease, were tested in 58 Japanese patients SLE, who fulfilled ARA diagnostic criteria, along 97 normal controls. class I II typed serologically using antisera provided by 11th Workshop. Among antigens, further DRB, DQ DP alleles defined DNA typing PCR/SSOP method. There significantly more HLA-B39, DRB1*1501, DRB5*0101 DQB1*0602 than This result suggested that haplotype HLA-DRB1*1501-DRB5*0101-DQA1*0102-DQB1*0602...
The concentration of soluble interleukin 2 receptor (IL-2R) was determined in the serum 54 patients with systemic lupus erythematosus (SLE) by an enzyme linked immunosorbent assay (ELISA) using two monoclonal antibodies IL-2R. Concentrations IL-2R SLE (study group) were significantly higher than 20 normal subjects (control group). relation between concentrations and clinical findings investigated. showed no particular manifestations did not correlate level anti-DNA antibody or CH50....
Objective: To describe the pre-conception status, pregnancy outcomes, and medication prevalence in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Crohn's disease (CD), ulcerative colitis (UC).Methods: E-mail-based questionnaire survey for Japan Maternal Fetal Intensive Care Unit Network hospitals inquiring clinical features of SLE, RA, CD UC complicated pregnancies 2 years.Results: The number among 69,810 deliveries was 184, 139, 27 178, respectively. Less than half were...
Abstract Background Patients with ulcerative colitis (UC) may be concerned about medication safety during preconception, pregnancy, and lactation, they should closely followed up to ensure that UC activity is controlled the perinatal period. Reported information on of ustekinumab pregnancy lactation limited. In this case report, we examined in a fetus breastfed infant reference drug concentrations maternal serum, cord blood, breast milk, serum. Case presentation A 36-year-old female who...