A5003587098- Systemic Lupus Erythematosus Research
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- Blood disorders and treatments
- Cell Adhesion Molecules Research
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Liver Diseases and Immunity
- Phagocytosis and Immune Regulation
- Systemic Sclerosis and Related Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Inflammatory Myopathies and Dermatomyositis
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Complement system in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone and Joint Diseases
- Reproductive System and Pregnancy
- Bone health and treatments
- Autophagy in Disease and Therapy
- Eosinophilic Disorders and Syndromes
Hokkaido University
2015-2024
Western Regional Hospital
2012
Health Sciences University of Hokkaido
2010
St Thomas' Hospital
1996-2001
St. Thomas Hospital
1996-1998
Abstract Objective To define the antiphospholipid score (aPL‐S) by testing multiple antibodies (aPL) and to evaluate its efficacy for diagnosis of syndrome (APS) predictive value thrombosis. Methods This study comprised 2 independent sets patients with autoimmune diseases. In first set (n = 233), aPL profiles were analyzed. Five clotting assays lupus anticoagulant 6 enzyme‐linked immunosorbent (IgG/IgM anticardiolipin antibodies, IgG/IgM anti–β ‐glycoprotein I, phosphatidylserine‐dependent...
Abstract Dysregulation of Th17 and Treg cells contributes to the pathophysiology many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite, inhibits cell differentiation promotes by orchestrating metabolic epigenetic reprogramming. Mechanistically, itaconate suppresses glycolysis oxidative phosphorylation in Th17- Treg-polarizing T cells. Following treatment with S-adenosyl-L-methionine/S-adenosylhomocysteine ratio 2-hydroxyglutarate levels are decreased...
The antiphospholipid syndrome (APS) is characterised by both arterial and venous thrombosis, recurrent pregnancy loss thrombocytopaenia in association with antibodies (aPL). To explore further the pathogenesis of thrombosis APS, we evaluated behaviour tissue factor (TF) pathway patients APS. Plasma antigen levels soluble TF inhibitor (TFPI), a physiological regulator dependent coagulation activation, were measured 57 APS (36 primary 21 secondary to systemic lupus erythematosus)....
The clinical significance of anti-β2 glycoprotein I (β2-GPI) antibodies was evaluated in patients with antiphospholipid syndrome (APS), primary and secondary to systemic lupus erythematosus (SLE). Anti-β2-GPI were tested 120 (39 APS, 32 APS SLE 49 without APS) by ELISA utilizing irradiated plates the absence cardiolipin. Anticardiolipin (aCL) antiphosphatidylserine also measured same using standardized assays. titres correlated strongly those aCL (r = 0.816, P 0.0001), 0.841, 0.0001)....
Abstract: Current classification criteria for definite APS recommend the use of one or more three positive standardized laboratory assays, including anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and directed to β 2 glycoprotein I (anti-β GPI) detect antiphospholipid (aPL) in presence at least two major clinical manifestations (i.e., thrombosis pregnancy morbidity) syndrome. Several other autoantibodies shown be phospholipids and/or their complexes with proteins coagulation...
Objective. Interstitial lung diseases (ILDs) complicated with PM or DM are frequently aggressive and refractory to treatment. Recently some reports have suggested the potential benefit of tacrolimus for severe ILD PM/DM. However, little evidence has yet shown efficacy in these settings. The aim this study was evaluate as a treatment PM-/DM-related ILD. Methods. This retrospective comprised 49 previously untreated patients diagnosed admitted Hokkaido University Hospital from January 2000 July...
Objective To explore a possible correlation between endothelin 1 (ET-1), the most potent endothelium-derived contracting factor that modulates vascular smooth muscle tone, and arterial disease in patients with antiphospholipid syndrome (APS). Methods Plasma levels of ET-1 were measured APS (n = 16) without 11) thrombosis non-APS 9). In addition, steady-state prepro-ET-1 messenger RNA (mRNA) determined endothelial cells treated range human monoclonal anticardiolipin antibodies (aCL) (as...
Objective A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) might contribute to a better identification antiphospholipid syndrome (APS). Accordingly, initial and replication retrospective, cross-sectional multicentre studies were conducted ascertain value aPS/PT for APS diagnosis. Methods In study (eight centres, seven countries), clinical/laboratory data retrospectively...
To assess the value of a combination anti-β2 -glycoprotein I (anti-β2 GPI) domain antibody and anti-phosphatidylserine/prothrombin complex (anti-PS/PT) tests for diagnosis antiphospholipid syndrome (APS).This cross-sectional study involved cohort patients who visited our clinic from April 2005 to March 2013. Tests GPI antibodies, IgG anti-PS/PT IgM together with criteria-defined antibodies (aPL), were performed in all patients. The total score (aPL-S) was calculated each patient according...
Objective: To study the clinical and immunological manifestations of antiphospholipid syndrome (APS) in Japanese population by a single-centre registration. Methods: In this retrospective cohort study, 141 consecutive patients with APS, fulfilling Sydney revised Sapporo criteria for definite who visited our autoimmune clinic from 1988 to 2010, were recruited followed up. All interviewed underwent general physical examination qualified rheumatologists on day blood sampling. Results: The...
We aimed to investigate the involvement of macroautophagy/autophagy in autoimmunity rheumatoid arthritis (RA) through citrullination VIM (vimentin) and its interaction with MHC class II synovial fibroblasts (SFs). The cell surface expression B7 costimulatory molecules on SFs was analyzed by flow cytometry after treatment IFNG/IFN-γ (interferon gamma). Intracellular citrullinated autoantigens were immunoblotting using serum from anti-citrullinated peptide antibodies (ACPA)-positive patient as...
The prevalence and clinical significance of antibodies against beta2-glycoprotein I (anti-beta2GPI) oxidized low-density lipoprotein (anti-ox-LDL) were evaluated as potential indicators arterial disease in patients with systemic lupus erythematosus (SLE) SLE secondary antiphospholipid syndrome (APS). IgG anti-beta2GPI anti-ox-LDL measured by enzyme-linked immunosorbent assay (ELISA) serum samples from 118 SLE, including 40 APS. positive 17% (20/118) patients. presence titres strongly...
Beta2-Glycoprotein I (beta2GPI) exon 7 polymorphism leads to a valine leucine amino acid exchange at position 247 in domain 5 of beta2GPI, between the phospholipid binding site and cryptic epitopes for anti-beta2GPI antibodies. Therefore, may affect conformational change beta2GPI exposure anticardiolipin antibodies (aCL) (= antibodies). In this study we analysed genetic British cohort well-defined antiphospholipid syndrome (APS) patients.This comprised 88 Caucasoid patients with APS [57...