A5043859838- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Reproductive Health and Technologies
- Endometriosis Research and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Systemic Lupus Erythematosus Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Prenatal Screening and Diagnostics
- Testicular diseases and treatments
- Sexual Differentiation and Disorders
- Ectopic Pregnancy Diagnosis and Management
- Renal Diseases and Glomerulopathies
- Gynecological conditions and treatments
- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Uterine Myomas and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Textile materials and evaluations
- S100 Proteins and Annexins
- Ultrasound Imaging and Elastography
Osaka Nishi Clinic
2016-2025
Institute for Animal Reproduction
2021-2024
Reproductive Science Center
2024
University of Hyogo
2018
Himeji University
2018
Kyoto Prefectural University of Medicine
2016
Tokai University
2002-2013
Osaka University of Arts
2009-2012
Weatherford College
2009
Saint Francis Hospital
2000
The aim of this prospective study was to investigate the prevalence chronic endometritis (CE) in infertile women with a history repeated implantation failure (RIF) and determine whether oral antibiotic treatment improves their live birth rate following embryo transfer (ET) cycles.Endometrial biopsy samples obtained from RIF were subjected immunohistochemistrical/histopathologic diagnosis CE. Following administration RIF/CE group, histopathologic cure rate, microbial detection reproductive...
Abstract: Current classification criteria for definite APS recommend the use of one or more three positive standardized laboratory assays, including anticardiolipin antibodies (aCL), lupus anticoagulant (LA), and directed to β 2 glycoprotein I (anti-β GPI) detect antiphospholipid (aPL) in presence at least two major clinical manifestations (i.e., thrombosis pregnancy morbidity) syndrome. Several other autoantibodies shown be phospholipids and/or their complexes with proteins coagulation...
Objective Assisted reproductive technology (ART), especially frozen–thawed embryo transfer (FET) in a hormone replacement cycle (HRC), is risk factor for placenta accreta spectrum (PAS). This study aimed to clarify the factors PAS related maternal background and ART techniques pregnancies achieved after FET an HRC. Study Design We performed case–control two tertiary perinatal centres Japan. Among 14,028 patients who delivered at ≥24 weeks of gestation or were transferred delivery between...
Although recent papers have suggested that psychological factors are implicated in the experience of infertility, few studies assessed this relationship a sample Japanese infertile women. This study was carried out order to clarify whether women emotional distress. A cross-sectional questionnaire performed assess states 101 compared 81 healthy pregnant The hospital anxiety and depression scale (HADS) profile mood (POMS) were administered. These questionnaires produced scores for...
The judicious selection of ovulation inhibitors in ovarian stimulation protocols is crucial for the success assisted reproductive technology (ART). Herein, we investigate dose-dependent effects chlormadinone acetate (CMA) and cetrorelix, two distinct inhibitors, on oocyte maturation patients with normal reserve, using univariable multivariable Poisson regression analyses. Patients undergoing progestin-primed (PPOS) CMA ( n = 299) or gonadotropin-releasing hormone antagonist (GnRH-ant)...
Abstract Aim: Associations have been reported between antiphospholipid antibodies (aPL), mainly anticardiolipin (aCL) and/or the lupus anticoagulant, and recurrent pregnancy losses (RPL). However, relatively few studies describing antiphosphatidylethanolamine (aPE) reported. We describe prevalence of aPL to both cardiolipin phosphatidylethanolamine in patients with RPL. Methods: Patients early ( n = 145) mid‐to‐late loss(es) 26) were screened for aPE aCL. Results: In losses, immunoglobulin G...
Earlier studies in platelet aggregation have shown that females seemed to greater aggregability than males as detected by conventional aggregometry which used light transmission (LT), but controversy still remains. This study was performed determine whether sex difference exists using the recently developed laser scattering (LS) method, can detect small aggregates (i.e., two or three platelets). Blood drawn from healthy volunteers (10 male and 10 female follicular phase after menstruation),...
Abstract Purpose To assess the clinical efficacy of personalized embryo transfer (pET) guided by a new endometrial receptivity test, ERPeak SM , in patients with recurrent implantation failure (RIF). Methods Recurrent all ages at two private Japanese clinics from April 2019 to June 2020 were retrospectively analyzed. The intervention group ( n = 244) received pET accordance testing results and was compared control 306) receiving standardized timing, non‐personalized (npET). In propensity...
PROBLEM: An increase in natural killer (NK)‐cell activity has been observed women with unexplained recurrent miscarriages. Because of the many similarities between infertility and early pregnancy loss patients, we investigated whether infertile had raised NK‐cell activity. METHOD OF STUDY: We tested 94 who, spite treatment, were unable to conceive for 6 or more months. was measured by using a chromium‐51 release cytotoxicity assay, K562 human myeloid leukemia cells as targets. RESULTS: group...
PROBLEM: Patients having in vitro fertilization and embryo transfer (IVF‐ET) failures show an increased incidence of antiphospholipid (aPL) antibodies; but controversy exists whether aPL can induce IVF‐failure. This study was designed to compare specificities between recurrent IVF‐failure patients versus repeated early pregnancy loss (RPL) patients. METHOD OF STUDY: Anticardiolipin (aCL), lupus anticoagulant (LA), antiphosphatidylserine (aPS), antiphosphatidylethanolamine (aPE), antinuclear...
Problem: Preconception high peripheral natural killer (NK) cell activity in women with recurrent spontaneous abortion can predict subsequent miscarriages. We have examined prospectively, for the first time, pregnancy rate patients unexplained infertility by measuring NK activity. Method of study: tested 94 infertile who despite treatment were unable to conceive 6 or more months (mean; 2.4 years). Peripheral was measured a chromium‐51 release cytotoxicity assay. Women followed 2 years and...
Citation Velayuthaprabhu S, Matsubayashi H, Sugi T, Nakamura M, Ohnishi Y, Ogura Tomiyama Archunan G. A unique preliminary study on placental apoptosis in mice with passive immunization of anti-phosphatidylethanolamine antibodies and anti-factor XII antibodies. Am J Reprod Immunol 2011; 66: 373–384 Problem Antiphospholipid have been investigated both humans animal models. In contrast, there are fewer reports describing (aPE) humans, no studies aPE till date. Clinically, FXII deficiency or...
Abstract Purpose We investigated the clinical results of Japanese men with Y chromosome microdeletions. Methods This study retrospectively examined 2163 azoospermic or severe oligozoospermic patients. frequency azoospermia factor (AZF) deletions and sperm retrieval rate (SRR) by microTESE in patients these deletions, then analyzed ICSI outcomes. Results Azoospermia were found 201 SRR was significantly higher than that control group (74.0% vs 20.4%, P < .001). Thirty‐three couples...
BACKGROUND: This study determined whether twins conceived through assisted reproduction technology (ART) have an increased risk of perinatal complications compared with natural twin pregnancies and investigated potential associated major factors. METHODS: retrospective consisted 199 born between 1994 2003. There were four groups according to conception modalities: 97 after spontaneous pregnancy, 24 induced ovulation, 28 intrauterine insemination (IUI) 50 IVF embryo transfer. Analysis...