A5001002762- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Angiogenesis and VEGF in Cancer
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Surgical Treatments
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cardiac Imaging and Diagnostics
- Cancer Mechanisms and Therapy
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Metastasis and carcinoma case studies
Chiba University
2016-2025
Aizawa Hospital
2015-2024
Shizuoka City Shimizu Hospital
2020-2024
Osaka University
1974-2023
Chiba Cancer Center
2023
Hijiyama University
2023
Waseda University
2022
Institute for Rural Engineering
2010-2022
National Agriculture and Food Research Organization
2009-2022
Tokai University
2010-2021
Pancreatic cancer is a malignant tumor with an extremely poor prognosis. The mechanisms of the aggressive growth and metastasis are not yet extensively understood. Over-expression epidermal factor receptor (EGFR) was suggested to be associated transformation pancreatic cancer. We examined EGFR expression in 77 cases invasive ductal adenocarcinoma pancreas, analyzed relation between pattern clinicopathological factors. immunoreactivity detected 41.6% (32/77) human cancers; i.e. diffuse 32.5%...
Oxaliplatin-based chemotherapy is associated with debilitating peripheral sensory neuropathy (PSN) for patients stage III colon cancer.To assess disease-free survival (DFS) and long-lasting PSN in treated 3 vs 6 months of adjuvant oxaliplatin-based chemotherapy.An open-label, multicenter, phase randomized clinical trial 1313 Asian cancer was conducted investigating the noninferiority chemotherapy. From August 1, 2012, to June 30, 2014, participants were 2 treatment groups. Data analyzed from...
The present study aimed to assess the efficacy and safety of lenvatinib verify possibility for expanded indication from REFLECT trial in patients with advanced hepatocellular carcinoma (HCC) real-world practice, primarily focusing on population that was excluded trial.We retrospectively collected data HCC who were administered 7 institutions Japan.Of 152 patients, 95 57 received first-line second- or later-line systemic therapies, respectively. median progression-free survival Child-Pugh...
Cell-retained isoforms of vascular endothelial growth factor A (VEGF-A) have been reported to play an essential role in tumor progression through stromal neovascularization malignant solid tumors. While more than 95% nonsmall cell lung carcinoma (NSCLC) expresses cell-retained VEGF-A isoform, the clinicopathologic implications neuropilin (NRP), considered specific receptor for limited types are not well understood.The authors examined NRP1 and NRP2 mRNA expression 68 NSCLCs 15...
PURPOSE: The aim of this study was to clarify the distribution lymph node metastasis in colorectal cancer. We also examined relationship between primary tumor (T) and regional (N) categories TNM (primary tumor, nodes, metastasis) classification. METHOD: Lymph nodes surgical specimens 311 consecutive patients with cancer were studied using modified clearing method. RESULTS: seen 59.2 percent total cases. upward rate 30.7 percent. In longitudinal spread, most within 10 cm. On oral side rectal...
We previously reported the beneficial effects of combination therapy interferon (IFN)-α/5-fluorouracil (FU) for advanced hepatocellular carcinoma (HCC) with tumour thrombi in major portal branches. This report describes results longer follow-up and includes more than double number patients relative to original report, evaluates role IFN-α/type 2 receptor (IFNAR2) expression on response therapy. The study subjects were 55 HCC branches vein (Vp3 or 4). They treated at least two courses...
Abstract: Background: Hepatocellular carcinoma (HCC) is a hypervascular tumor and angiogenesis plays an important role in its progression. Angiogenesis regulated by balance between pro antiangiogenic molecules. The aim of this study was to investigate the expressions angiogenic factors elucidate their roles HCC. Methods: We investigated immunohistochemical expression vascular endothelial growth factor (VEGF), angiopoietins (Ang‐1 Ang‐2), hypoxia‐induced factor‐1α (HIF‐1α) thrombospondin‐1...
The Turcot syndrome (TS) is a rare, probably autosomal recessive, disorder characterized by development of primary neuroepithelial tumors the central nervous system (CNS) and numerous adenomatous colorectal polyps. To examine possible involvement mutations APC gene, which responsible for familial polyposis (FAP), in syndrome, we examined DNAs from TS patients alterations this gene means ribonuclease protection analysis. Germ-line were detected each three unrelated cases TS, additional...
Combination therapy with oral fluoropyrimidine and irinotecan has not yet been established as first-line treatment of metastatic colorectal cancer (mCRC). We carried out a randomized, open-label, phase III trial to determine whether S-1 plus bevacizumab is noninferior mFOLFOX6 or CapeOX in terms progression-free survival (PFS).Patients from 53 institutions who had previously untreated mCRC were randomly assigned (1 : 1) receive either (control group) (experimental group; 3-week regimen:...
A biweekly TAS-102 plus BEV schedule in patients with heavily pretreated mCRC showed equivalent efficacy less toxicity compared the current of combination. Biweekly combination could reduce unnecessary dose reduction TAS-102, maintain higher doses, and possibly be effective even cases without chemotherapy-induced neutropenia (CIN). The prespecified subgroup analysis this study an obvious association between CIN within first two cycles prognosis BEV.TAS-102 (trifluridine/tipiracil)...
Abstract Human small extracellular vesicles (sEVs) derived from adipose‐derived mesenchymal stromal cells (ASC) have been reported to suppress the progression of osteoarthritis (OA) in animal studies and subsequently, translation this potential assess their clinical efficacy is anticipated. However, fabrication protocols for sEVs eliminate contamination by culture medium‐derived components need be established prior use. The purpose present was elucidate influence contaminants on biological...
Chemotherapy-induced peripheral neuropathy (CIPN) is a painful, dose-limiting adverse effect of commonly used chemotherapeutic agents. The purpose this exploratory study was to evaluate the efficacy and safety mirogabalin in patients with moderate severe CIPN during chemotherapy effects 12 weeks' intervention on completion severity.Patients experiencing while undergoing oxaliplatin- or taxane-containing for colorectal, gastric, non-small-cell lung, breast cancer received at between 5 15 mg...
Two subtypes of thrombospondin (TSP-1 and TSP-2) have inhibitory roles in angiogenesis vitro, although the biological significance these TSP isoforms has not been determined vivo. We examined TSP-1 TSP-2 gene expression by reverse transcription polymerase chain reaction (RT-PCR) analysis 61 colon cancers. Thirty-eight cancers were positive for showed hepatic metastasis at a significantly lower incidence than those without (P = 0.02). was associated with M0 stage 0.03), whereas no apparent...
Galectin-3 is a beta-galactoside-specific lectin that binds to laminin sugar-sites and involved in tumor malignancy. expression relation primary liver metastasis of colorectal cancer was examined determined its involvement progression metastasis. Immunohistochemical staining galectin-3 performed on 117 lesions 15 metastases using TIB166 monoclonal antibody. The evaluated by grading the intensity as either negative, weakly positive, or strongly positive. Normal mucosa all patients were...
Objective. To determine the relationship between expression of interleukin‐1β (IL‐1β) and IL‐1 receptor antagonists (IL‐1ra) in subacromial bursa shoulder pain rotator cuff diseases.