A5108095347- Cerebrovascular and Carotid Artery Diseases
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Acute Ischemic Stroke Management
- Gastric Cancer Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Lymphatic System and Diseases
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Pressure Ulcer Prevention and Management
- Wound Healing and Treatments
- Breast Cancer Treatment Studies
- Neurological Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Esophageal and GI Pathology
- Blood Pressure and Hypertension Studies
- Diabetic Foot Ulcer Assessment and Management
- Coral and Marine Ecosystems Studies
- Neuroendocrine Tumor Research Advances
- Breast Lesions and Carcinomas
- Neurological Complications and Syndromes
Yamaguchi Prefectural University
2006-2024
National Defense Academy of Japan
2024
Nara Women's University
2021
Tokai University
2001-2020
Hoshigaoka Medical Center
2013-2019
Japan Community Healthcare Organization
2017
Suzuki (Japan)
2016
Hirosaki University
2012-2015
Osaka University
2005-2014
Okinawa Institute of Science and Technology Graduate University
2011-2014
Coral reefs are among the most biologically diverse ecosystems on planet and of great economic importance. They under threat because scleractinian corals at their core susceptible to ocean acidification rising seawater temperatures. The genome reef-building coral Acropora digitifera has been analysed with a view understanding molecular basis symbiosis responses environmental change. seems have lost key enzyme cysteine biosynthesis, so may be dependent its symbionts for this amino acid. It...
Pancreatic cancer is a malignant tumor with an extremely poor prognosis. The mechanisms of the aggressive growth and metastasis are not yet extensively understood. Over-expression epidermal factor receptor (EGFR) was suggested to be associated transformation pancreatic cancer. We examined EGFR expression in 77 cases invasive ductal adenocarcinoma pancreas, analyzed relation between pattern clinicopathological factors. immunoreactivity detected 41.6% (32/77) human cancers; i.e. diffuse 32.5%...
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTDependence of TiO2 Photocatalytic Activity upon Its Film ThicknessHiroaki Tada and Makiko TanakaView Author Information Nippon Sheet Glass Techno-Research Co. Ltd., 1, Kaidoshita, Konoike, Itami, Hyogo 664, Japan Cite this: Langmuir 1997, 13, 2, 360–364Publication Date (Web):January 22, 1997Publication History Received2 May 1996Revised22 October 1996Published online22 January 1997Published inissue 1...
<h3>Objective:</h3> To determine whether chronic kidney disease (CKD) is associated with incident dementia independent of cerebral small-vessel (SVD) in patients vascular risk factors. <h3>Methods:</h3> Using data from a Japanese cohort participants factors an ongoing observational study 2001, we evaluated the association between CKD at baseline and dementia. Baseline brain MRI was used to SVD (lacunar infarction, white matter hyperintensities), medial-temporal atrophy, subcortical atrophy....
Cerebral microbleeds (CMB) are observed in the elderly and have been regarded as one of manifestations small vessel disease. Although inflammatory processes attracted much attention not only large-artery disease, but also their involvement CMB remains to be determined. The purpose this study is clarify relations between marker levels CMB.Four hundred thirty-one patients without histories cerebrovascular diseases were prospectively enrolled. presence number assessed on gradient-echo magnetic...
Lung cancer is a leading cause of mortality worldwide and patients occasionally develop local recurrence or distant metastasis soon after curative resection. Reports new therapeutic strategies for lung squamous cell carcinoma (SqCC) are extremely rare, while selective anticancer therapy has been reported adenocarcinoma. The aim this study was to identify clinicopathological prognostic factors SqCC. We analyzed tumor budding infiltrative patterns (INF) in 103 cases surgically-resected Tumor...
<h3>Objective:</h3> To investigate whether cerebral microbleeds (CMBs) are independently associated with incident dementia in patients vascular risk factors. <h3>Methods:</h3> Using data from a Japanese cohort of participants factors an observational study 2001, we evaluated the association between CMBs at baseline and dementia. Baseline brain MRI was used to determine small-vessel disease (CMBs, lacunar infarcts, white matter hyperintensities) atrophy. Cox proportional hazards analyses were...
Genome sequencing of Symbiodinium minutum revealed that 95 109 plastid-associated genes have been transferred to the nuclear genome and subsequently expanded by gene duplication. Only 14 remain in plastids occur as DNA minicircles. Each minicircle (1.8-3.3 kb) contains one a conserved noncoding region containing putative promoters RNA-binding sites. Nine types RNA editing, including novel G/U type, were discovered transcripts but not nucleus. In contrast editing sites dinoflagellate...
Homocysteine has been identified as a potential risk factor for stroke, cerebral small-vessel diseases (SVD), and dementia.The present study aimed to investigate the predictive value of homocysteine levels on incident dementia while simultaneously controlling MRI findings vascular factors.Within Japanese cohort participants with factors in an observational study, we evaluated association between baseline total (tHcy) (per 1 μmol/L tertile tHcy), prevalence MRI-findings at baseline, all-cause...
Approximately one quarter of the acute ischemic stroke patients notice event at awakening. Such with awakening are usually excluded from thrombolysis, since time onset cannot be definitely identified. We compared hyperacute CT findings those known to assess whether is shortly before awakening.Subjects were cardioembolic who consecutively admitted our department within 3 h after recognition during period between January 2000 and March 2003. The classified into three groups: group A onset, B...
Objective— Basilar arterial (BA) dolichoectasia is associated with cerebral small-vessel disease and stroke. However, the association between moderate dilation of BA or subsequent cardiovascular events remains unclear. This study aims to clarify factors related diameter whether an independent predictor events. Approach Results— The subjects comprised 493 outpatients atherosclerotic risk factors. diameter, lacunar infarct, severity deep white matter hyperintensities, intracranial...
Podoplanin is a small membrane mucin, which involved in cell migration and cancer invasion. However, the roles of podoplanin esophageal squamous carcinoma (ESCC) are poorly understood. In present study, 139 cases surgically resected ESCC were analyzed clinicopathological significance expression was demonstrated. positive 66.2% (92/139) samples; with weak 32.4% (45/139), strong 33.8% (47/139). Membrane significantly associated tumor status (P=0.001), venous invasion (P=0.035) Union for...
Pancreatic cancer is a malignant tumor with an extremely poor prognosis. Thrombospondin-1 (TSP-1) was suggested to be potential regulator of growth and metastasis. We examined TSP-1 expression in 77 cases invasive ductal adenocarcinoma the pancreas, analyzed correlation between pattern clinicopathological features pancreatic cancer. immunoreactivity detected stroma. The diffusely positive focally patterns were found 33 (42.9%) 40 (51.9%) cases, respectively. diffuse significantly correlated...
The telomere at the end of a linear chromosome plays crucial roles in genome stability. In fission yeast Schizosaccharomyces pombe, Rap1 protein, one central players telomeres, associates with multiple proteins to regulate various functions, such as maintenance DNA length, protection, heterochromatin, and clustering meiosis. molecular bases interactions between its partners, however, remain largely unknown. Here, we describe identification interaction domains partners. Bqt1/Bqt2 complex,...