A5082341786- Nanoparticle-Based Drug Delivery
- Advanced Polymer Synthesis and Characterization
- RNA Interference and Gene Delivery
- Lanthanide and Transition Metal Complexes
- Nanoplatforms for cancer theranostics
- Colorectal and Anal Carcinomas
- Surfactants and Colloidal Systems
- Hepatocellular Carcinoma Treatment and Prognosis
- Monoclonal and Polyclonal Antibodies Research
- MRI in cancer diagnosis
- Hydrogels: synthesis, properties, applications
- Retinoids in leukemia and cellular processes
- Liver Disease Diagnosis and Treatment
- Advanced Drug Delivery Systems
- Colorectal Cancer Surgical Treatments
- Polymer Surface Interaction Studies
- Immunotherapy and Immune Responses
- Photoacoustic and Ultrasonic Imaging
- Analytical Chemistry and Chromatography
- Ultrasound and Hyperthermia Applications
- Advanced MRI Techniques and Applications
- biodegradable polymer synthesis and properties
- Oral microbiology and periodontitis research
- Inflammatory Bowel Disease
- Radiomics and Machine Learning in Medical Imaging
Jikei University School of Medicine
2014-2025
Chiba University
1990-2022
ABB (Japan)
2016-2021
AbbVie (Japan)
2019-2021
Kyushu University
2018-2020
Toyobo (Japan)
2018-2020
Institute of Molecular Functional Materials
2018
Japanese Foundation For Cancer Research
2012-2017
Tokai University Hospital
2017
Kanagawa Academy of Science and Technology
2005-2012
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicelles based on AB block copolymers of poly(ethylene oxide) and poly(.beta.-benzyl L-aspartate)G. Kwon, M. Naito, Yokoyama, T. Okano, Y. Sakurai, K. KataokaCite this: Langmuir 1993, 9, 4, 945–949Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/la00028a012https://doi.org/10.1021/la00028a012research-articleACS PublicationsRequest reuse...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of micelle-forming polymer-drug conjugatesMasayuki Yokoyama, Glenn S. Kwon, Teruo Okano, Yasuhisa Sakurai, Takashi Seto, and Kazunori KataokaCite this: Bioconjugate Chem. 1992, 3, 4, 295–301Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/bc00016a007https://doi.org/10.1021/bc00016a007research-articleACS PublicationsRequest reuse...
Although primary antiviral CD8+ cytotoxic T lymphocytes (CTL) can be induced in mice depleted of CD4+ cells, the role generation and maintenance memory CTL is uncertain. This question, consequences upon vaccine-mediated protection, were investigated transgenic CD4 knockout (CD4ko) mice, which lack lymphocytes. Infection immunocompetent C57BL/6 with lymphocytic choriomeningitis virus (LCMV), or recombinant vaccinia viruses bearing appropriate LCMV sequences, induces long-lasting protective...
DNA vaccination has been evaluated with the lymphocytic choriomeningitis virus (LCMV) model system. Plasmid encoding LCMV nucleoprotein, when injected intramuscularly, induces both antiviral antibodies and cytotoxic T lymphocytes. Injection of nucleoprotein or viral glycoprotein confers protection against normally lethal challenge in a major histocompatibility complex-dependent manner. The conferred is incomplete, but it most probably mediated by induced
ABSTRACT Our previous studies have shown that isolated cytotoxic T lymphocyte (CTL), B-cell, and T-helper epitopes, for which we coined the term minigenes, can be effective vaccines; when expressed from recombinant vaccinia viruses, these short immunogenic sequences confer protection against a variety of viruses bacteria. In addition, previously demonstrated utility DNA immunization using plasmids encoding full-length viral proteins. Here combine two approaches evaluate effectiveness...
Mercaptoundecahydrododecaborate (BSH)-encapsulating 10% distearoyl boron lipid (DSBL) liposomes were developed as a delivery vehicle for neutron capture therapy. The current approach is unique because the liposome shell itself possesses cytocidal potential in addition to its encapsulated agents. BSH-encapsulating DSBL have high content (B/P ratio: 2.6) that enables us prepare solution with 5000 ppm concentration. displayed excellent efficacy tumor: concentrations reached 174, 93, and 32 at...
Abstract Synthesis of a novel conjugate anticancer drug adriamycin, poly(ethylene glycol)‐ block ‐poly(aspartic acid), and immunoglobulin G is reported. Poly(ethylene binding adriamycin on the poly(aspartic acid) chain, showed an excellent water‐solubility despite introduction large amount strongly hydrophobic was found to form micellar structure in aqueous solution. Efficient coupling between achieved via disulfide linkages.