A5076850546- Chemical Reaction Mechanisms
- Geometric Analysis and Curvature Flows
- Chemical Synthesis and Analysis
- Copper Interconnects and Reliability
- Sports injuries and prevention
- Geometry and complex manifolds
- Fullerene Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- 3D IC and TSV technologies
- Phosphodiesterase function and regulation
- Axial and Atropisomeric Chirality Synthesis
- Nutrition and Health in Aging
- Semiconductor materials and devices
- Graphene research and applications
- Body Composition Measurement Techniques
- Advanced Differential Geometry Research
- Synthesis and Catalytic Reactions
- Electronic Packaging and Soldering Technologies
- Stroke Rehabilitation and Recovery
- Heat Transfer Mechanisms
- Fluid Dynamics and Turbulent Flows
- Foot and Ankle Surgery
- Health and Wellbeing Research
- Boron and Carbon Nanomaterials Research
- Asymmetric Hydrogenation and Catalysis
International University of Health and Welfare
2010-2025
Osaka University
1990-2022
The Open University of Japan
2021
Hyogo Medical University
2018
Hiroshima Shudo University
2016-2017
Hiroshima University
1991-2016
Mita Hospital
2012
The University of Tokyo
2011
Seirei Christopher University
2009
Jawaharlal Nehru Centre for Advanced Scientific Research
2008
Single crystals of three-dimensional (3D) C60 polymer were prepared by the topotactic conversion two-dimensional (2D) single at a pressure 15 GPa 600 degrees C. The x-ray crystal study revealed that 3D crystallized in body centered orthorhombic space group Immm, and spherical monomer units substantially deformed to rectangular parallelepiped (cuboidal) shapes, each unit being bonded eight cuboidal neighbors via [3 + 3] cycloaddition. was electron conductive, contrast with nonconductive...
1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed new structural class of PDE5 inhibitors. The requirements for potent and specific inhibition were revealed in 1-arylnaphthalene lignan series, 1-(3-bromo-4, 5-dimethoxyphenyl)-5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinylcarbon yl]-2-(methoxycarbonyl)naphthalene hydrochloride (27q) showed the most (PDE5 IC50 = 6.2 nM, selectivity against PDE1, -2, -3, -4 >16 000). It is noteworthy that 27q has best...
Fullerene C60 monomer crystals were compressed to a face-centered cubic (fcc) phase with lattice parameter of = 11.93(5) Å and micro-Vickers hardness 4500 kg/mm2 using high-pressure high-temperature conditions 15 GPa at 500−600 °C. The is compatible that boron nitride (c-BN), suggesting the formation 3D polymer. single-crystal X-ray structural analysis revealed each molecule in polymer was linked 12 nearest neighbors by [2+2] cycloaddition between common pentagon−hexagon (56) edges. However,...
A novel class of potent and selective phosphodiesterase 5 (PDE5) inhibitors, 4-aryl-1-isoquinolinone derivatives, which have been designed by the comparison structure cGMP a previously reported 1-arylnaphthalene lignan, was disclosed. Among these compounds, methyl 2-(4-aminophenyl)-1,2-dihydro-1-oxo-7-(2-pyridinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-3-isoquinoline carboxylate dihydrochloride (36a) exhibited PDE5 inhibitory activity (IC(50) = 1.0 nM) with high isozyme selectivities ratio:...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereospecific Amination by Dynamic Kinetic Resolution Utilizing 2-Oxoimidazolidine-4-carboxylate as a Novel Chiral AuxiliaryHitoshi Kubota, Akira Kubo, Masami Takahashi, Ryo Shimizu, Tadamasa Da-te, Kimio Okamura, and Ken-ichi NunamiCite this: J. Org. Chem. 1995, 60, 21, 6776–6784Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October...
Abstract Total synthesis of a lanthionine peptide nisin was achieved by the successive condensations four segments including cyclic parts and C-terminal linear segment dehydroalanine, followed deprotection procedure with anhydrous HF. Modified reaction conditions for Hofmann degradation were applied to prepare dehydroalanine residue from 2,3-diaminopropionic acid residue. The final HF proceeded without decomposition dehydroamino residues which are generally labile in acidic media. synthetic...
Stereoselective carbon−carbon bond formation by dynamic kinetic resolution using tert-butyl (4S)-1-methyl-2-oxoimidazolidine-4-carboxylate (1) as a chiral auxiliary was developed. Reaction of diastereomeric mixture (4S)-3-[(2RS)-2-bromoacyl]-1-methyl-2-oxoimidazolidine-4-carboxylates (2) with malonic ester enolate in HMPA predominantly afforded (4S)-3-[(2R)-2-alkyl-3,3-bis(alkoxycarbonyl)propionyl]-1-methyl-2-oxoimidazolidine-4-carboxylate [(S,R)-8] good yields. The stereoselectivity this...
A new 'intelligent' polymer system was developed utilizing the binding and exchange of phenylboronic acid (PBA) with polyols and/or glucose. In this improved system, an amine component incorporated into chain along PBA, to enhance between PBA glucose under physiological conditions. The PBA-based formed by free-radical copolymerization 3-methacrylamidophenylboronic (MAPB) comonomers, N,N-dimethylaminopropylacrylamide (DMAPAA) acrylamide (AAm) in presence N,N'-methylenebis(acrylamide)...
[Purpose] The simultaneous application of static stretching and neuromuscular electrical stimulation (NMES) to calf muscles may enhance physiological parameters in young healthy individuals; however, the efficacy this intervention potential sex variation remain be elucidated. present study aimed investigate these aspects. [Participants Methods] Thirty university students (15 males 15 females) participated study. All participants simultaneously underwent NMES for 4 min while lying on an...
The moduli space of left-invariant pseudo-Riemannian metrics on a given Lie group is defined as the orbit certain isometric action some pseudo- Riemannian symmetric space. In terms space, we formulate procedure to obtain generalization Milnor frames for group. This an analogue recent studies metrics. this paper, describe particular parabolic subgroup, and then apply it so-called groups real hyperbolic spaces, also three-dimensional Heisenberg As corollary show that all arbitrary signature...
Even if the trajectory in a viscous flow system stays within low dimensional subspace state space, reinforcement learning (RL) requires many observables active control problem. This is because are assumed to follow policy-independent Markov decision process usual RL framework and full observation of required satisfy this assumption. Although with partially observable condition generally difficult task, we construct consistent algorithm using property flow. Using typical examples control,...
[Purpose] In this study, we investigated the effectiveness of elastic tape in increasing dorsiflexion angle and plantar flexor strength healthy individuals. [Participants Methods] This randomized controlled trial included 24 university students who were categorized into following groups (12 participants each group): intervention group (elastic was applied to dominant foot) control (no performed). We performed intergroup comparison pre- post-intervention angles strength. Additionally,...
Absorption and excretion of a new antitumor drug, 1-hexylcarbamoyl-5-fluorouracil (HCFU), in cancer patients were investigated during the term its Phase I study. HCFU was administered per os to at dose 5 21 n (n = 1 mg/kg/day). Serum urine concentrations 5-fluorouracil (5-FU) intermediates which consisted 1-(5-hydroxyhexylcar-bamoyl)-5-FU (HHCFU), 1-(5-oxohexylcarbamoyl)-5-FU (OHCFU), 1-carboxypentylcarbamoyl-5-FU (CPEFU) l-carboxypropylcarbamoyl-5-FU (CPRFU) measured by bioassay method...
A robust embedded ladder-oxide (k=2.9)/copper (Cu) multilevel interconnect is demonstrated for 0.13 µm complementary metal oxide semiconductor (CMOS) generation. stable intermetal dielectric (IMD) integrated by the Cu metallization with a minimum wiring pitch of 0.34 µm, and single damascene (S/D) Cu-plug structure applied. An 18% reduction in capacitance obtained compared that SiO2 IMDs. The superior controllability thickness S/D process enables us to enhance MPU maximum frequency easily....