A5035237919- T-cell and Retrovirus Studies
- earthquake and tectonic studies
- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Cardiovascular Health and Disease Prevention
- Seismology and Earthquake Studies
- Glycosylation and Glycoproteins Research
- Nutrition and Health in Aging
- CRISPR and Genetic Engineering
- Vector-Borne Animal Diseases
- Hematopoietic Stem Cell Transplantation
- Adipokines, Inflammation, and Metabolic Diseases
- Monoclonal and Polyclonal Antibodies Research
- Bladder and Urothelial Cancer Treatments
- Lymphoma Diagnosis and Treatment
- Animal Disease Management and Epidemiology
- Immune Cell Function and Interaction
- Erythrocyte Function and Pathophysiology
- Prostate Cancer Treatment and Research
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Hemoglobinopathies and Related Disorders
- Cancer Immunotherapy and Biomarkers
Nagasaki University
2016-2025
Kyushu University Hospital
2017-2024
Nagasaki University Hospital
2003-2024
Teikyo University Chiba Medical Center
2020-2024
National Research Institute for Earth Science and Disaster Resilience
2011-2024
Kyushu University
1995-2024
Toho University
2024
Kihoku hospital
2024
Wakayama Medical University
2018-2024
Kagoshima University
2001-2024
We characterized leukemia stem cells (LSC) in chronic phase myelogenous (CML) using a transgenic mouse model. LSC were restricted to with long-term hematopoietic cell (LTHSC) phenotype. CML LTHSC demonstrated reduced homing and retention the bone marrow (BM), related decreased CXCL12 expression BM, resulting from increased G-CSF production by cells. Altered cytokine BM was associated selective impairment of normal growth advantage LTHSC. Imatinib (IM) treatment partially corrected...
Reactivating the fetal globin gene Mutation of adult-type genes causes sickle cell disease and thalassemia. Although treating these hemoglobinopathies with therapy is possible, there a pressing need for pharmacologic approaches to treat general patient populations. One promising approach reactivate repressed expression fetal-type hemoglobin (HbF) in adult erythroid cells. Masuda et al. reveal molecular mechanism governing HbF repression as mediated by LRF/ZBTB7A transcription factor. The...
Focal mechanism and slip history of the 2011 Mw 9.1 off Pacific coast Tohoku, Japan earthquake were derived rapidly from teleseismic body surface waves. Multiple double couples (MDC) analysis was first conducted using 1-hour long period seismic waves, yielding a single couple with moment 5.06×1022 N m, whose low angle nodal plane orients 199° dips 10° west. Spatiotemporal rupture then constrained both broadband waves The solution updated twice in three days. Our preferred model, which based...
The immune checkpoint ligand PD-L1 and the transmembrane mucin MUC1 are upregulated in triple-negative breast cancer (TNBC), where they contribute to its aggressive pathogenesis. Here, we report that genetic or pharmacological targeting of oncogenic subunit MUC1-C is sufficient suppress expression TNBC cells. Mechanistic investigations showed acted elevate
// Masanori Hasegawa 1 , Hidekazu Takahashi 1,3 Hasan Rajabi Maroof Alam Yozo Suzuki 1,4 Li Yin Ashujit Tagde Takahiro Maeda Masayuki Hiraki Vikas P. Sukhatme 2 and Donald Kufe Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA Beth Israel Deaconess Center, 3 Department of Gastrointestinal Surgery, Graduate School Medicine, Osaka University, Suita City, Osaka, Japan 4 Gastroenterological Police Hospital, Correspondence to: Kufe, email: Keywords : xCT, MUC1-C, CD44v,...
Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that proto-oncogene LRF plays an essential role versus cell-fate decision. We demonstrate is key for instructing early progenitors mice develop lineage by repressing cell-instructive signals produced signal protein, Notch. propose a new model commitment, acts as master regulator of cell's determination lineage.
Abstract Acquisition of the arterial and haemogenic endothelium fates concurrently occur in aorta–gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The programme depends on Dll4 endothelium/HSC Jag1-mediated Notch1 signalling. How distinguishes executes these different programmes response particular ligands is poorly understood. By using two activation trap mouse models with sensitivity, here we show that endothelial cells HSCs originate from distinct...
Abstract Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein overexpressed in castration-resistant (CRPC) and NEPC, but its specific role unknown. Here, we demonstrate that upregulation of androgen-dependent PC cells suppresses androgen receptor (AR) axis signaling induces the neural BRN2 transcription factor. activates a MYC→BRN2 pathway association induction MYCN, EZH2 NE differentiation markers (ASCL1, AURKA...
Human cancer cells are irradiated by laser-driven quasimonoenergetic protons. Laser pulse intensities at the 5×1019 W/cm2 level provide source and acceleration field for protons that subsequently transported four energy-selective dipole magnets. The transport line delivers 2.25 MeV with an energy spread of 0.66 a bunch duration 20 ns. survival fraction in vitro from human salivary gland tumor is measured colony formation assay following proton irradiation dose levels up to 8 Gy, which single...
Background A novel index, the cardio-ankle vascular index (CAVI), which reflects stiffness of aorta, femoral artery, and tibial was recently developed by measuring brachial - ankle pulse wave velocity blood pressure. Methods Results In present study 1,014 Japanese adults from general population were screened to clarify correlation between CAVI other existing markers related atherosclerosis, including carotid intima media thickness (CIMT) homocysteine (HCY). strongly associated with age in...