A5101649793- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- CNS Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Hematological disorders and diagnostics
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Parvovirus B19 Infection Studies
- Cell Adhesion Molecules Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Cutaneous lymphoproliferative disorders research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Ear and Head Tumors
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Glutathione Transferases and Polymorphisms
- Polyomavirus and related diseases
Sichuan University
2022-2023
Cedars-Sinai Medical Center
2014-2022
West China Hospital of Sichuan University
2022
Nanchang Center for Disease Control and Prevention
2019
Southern Medical University
2016-2017
Nanfang Hospital
2016-2017
Union Hospital
2016
City Of Hope National Medical Center
2005-2014
Chinese Academy of Sciences
2012
Key Laboratory of Guangdong Province
2012
We characterized leukemia stem cells (LSC) in chronic phase myelogenous (CML) using a transgenic mouse model. LSC were restricted to with long-term hematopoietic cell (LTHSC) phenotype. CML LTHSC demonstrated reduced homing and retention the bone marrow (BM), related decreased CXCL12 expression BM, resulting from increased G-CSF production by cells. Altered cytokine BM was associated selective impairment of normal growth advantage LTHSC. Imatinib (IM) treatment partially corrected...
It is not uncommon for some B-lineage non-Hodgkin lymphomas (NHLs) to aberrantly coexpress T-cell markers, particularly CD5, as well CD7, CD2, CD4, and/or CD8 in rare cases. Cases of CD3-positive B-cell NHL, however, have previously been described the literature. We present 4 cases large lymphoma coexpressing marker CD3 and markers demonstrating clonal rearrangement immunoglobulin genes but γ receptor gene. To our knowledge, this represents first series report NHL T-lineage–specific CD3. The...
The soluble ectodomain of fibroblast growth factor receptor-IIIc (sFGFR2c) is able to bind (FGF) ligands and block the activation FGF-signaling pathway. In this study, sFGFR2c inhibited lung fibrosis dramatically in vitro vivo. upregulation α-smooth muscle actin (α-SMA) fibroblasts by transforming factor-β1 (TGF-β1) an important step process fibrosis, which FGF-2, released TGF-β1, involved. α-SMA induction TGF-β1 via both extracellular signal-regulated kinase 1/2 (ERK1/2) Smad3 pathways...
Whether membrane-anchored PD-L1 homodimerizes in living cells is controversial. The biological significance of the homodimer waits to be expeditiously explored. However, characterization full-length challenging, and unconventional approaches are needed. By using genetically incorporated crosslinkers, we showed that full length forms homodimers tetramers cells. Importantly, homodimerized intracellular domains play critical roles its complex glycosylation. Further analysis identified three key...
Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group an intermediate prognosis. Previous studies have suggested that Fms-like tyrosine kinase-3 internal tandem duplication (FLT3/ITD) mutation-positive may represent a distinctive We analyzed clinical and pathologic features 15 cases FLT3/ITD mutation. In comparison patients without mutation, FLT3/ITD+ are...
We describe a composite lymphoma with recurrent Hodgkin and diffuse large B-cell components manifesting as single, perforated small intestinal tumor in 56-year-old man history of classical recent relapse the bone marrow. The resected mass had 2 morphologically immunophenotypically distinct components; 1 showed pleomorphic cellular infiltrate fibrosis contained numerous, Hodgkin/Reed-Sternberg–like cells variants. were CD30+ focally positive for CD15 but CD20–, CD79a–, PAX-5–. In situ...
We describe a composite lymphoma with recurrent Hodgkin and diffuse large B-cell components manifesting as single, perforated small intestinal tumor in 56-year-old man history of classical recent relapse the bone marrow. The resected mass had 2 morphologically immunophenotypically distinct components; 1 showed pleomorphic cellular infiltrate fibrosis contained numerous, Hodgkin/Reed-Sternberg–like cells variants. were CD30+ focally positive for CD15 but CD20–, CD79a–, PAX-5–. In situ...
Abstract In the current study, we investigated C/EBPA gene mutations and promoter hypermethylation in a series of 53 patients with CN‐AML. addition, also analyzed two other frequent ( FLT3/ITD NPM1 ) these correlated them alterations. 13/53 were FLT3/ITD+/NPM1‐ , 11/53 FLT3/ITD+/NPM1+ 9/53 FLT3/ITD‐/NPM1+ 20/53 FLT3/ITD‐/NPM1‐ . Four cases displayed mutations, whereas 49 had only C/EBP A wild‐type alleles. Of four positive cases, three N‐terminal only, one patient both N‐ C‐terminal region....
How pathogens manipulate host UPRER to mediate immune evasion is largely unknown. Here, we identify the zinc finger protein ZPR1 as an interacting partner of enteropathogenic E. coli (EPEC) effector NleE using proximity-enabled crosslinking. We show that assembles via liquid-liquid phase separation (LLPS) in vitro and regulates CHOP-mediated at transcriptional level. Interestingly, studies binding ability with K63-ubiquitin chains, which promotes LLPS ZPR1, disrupted by NleE. Further...
Indolent NK-cell lymphoproliferative disorder, also known as chronic natural killer (NK) cell large granular lymphocytosis (leukemia), is a very rare entity in the World Health Organization (WHO) Classification of Tumors Hematopoietic & Lymphoid Tissues. Unlike aggressive leukemia, which malignant, WHO does not specify whether indolent disorder reactive or neoplastic. Patients with are usually asymptomatic older adults who have nonprogressive, stable clinical course. We report an unusual...
Posttransplant lymphoproliferative disorders (PTLDs), a heterogeneous group of monoclonal or polyclonal lesions, occur in immunosuppressed patients after solid organ bone marrow transplantation. Although most PTLDs are Epstein-Barr virus (EBV)+ and seem to represent EBV-induced proliferations (or less often polyclonal) B, T, plasma cells, subset is EBV-. Because Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) has been described association with the development...
Rare cases of B cell lymphomas do not express conventional markers (CD20, CD79a and PAX5), these types include anaplastic lymphoma kinase (ALK)-positive large lymphoma, plasmablastic primary effusion the solid variant extracavitary human herpesvirus 8 (HHV8)-positive lymphoma. Establishing accurate diagnoses can be challenging, often requires a panel immunohistochemical stains, molecular assays cytogenetic studies. cell-specific transcription factors, Oct2 Bob1, have been shown to expressed...