A5060550234- Osteoarthritis Treatment and Mechanisms
- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Bone and Joint Diseases
- Total Knee Arthroplasty Outcomes
- Periodontal Regeneration and Treatments
- Orthopedic Infections and Treatments
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Bone health and treatments
- Bone Tissue Engineering Materials
- Tendon Structure and Treatment
- Lower Extremity Biomechanics and Pathologies
- Silk-based biomaterials and applications
- Hip and Femur Fractures
- Bone fractures and treatments
- Electrospun Nanofibers in Biomedical Applications
- Bone health and osteoporosis research
- Spine and Intervertebral Disc Pathology
- Sports injuries and prevention
- Reconstructive Surgery and Microvascular Techniques
- Infection Control and Ventilation
- Spinal Fractures and Fixation Techniques
- Extracellular vesicles in disease
Osaka University
2016-2025
Kansai Rosai Hospital
2011-2024
Ministry of Health Labour and Welfare
2024
Steadman Philippon Research Institute
2021
Università Campus Bio-Medico
2021
Colorado State University
2021
OASI Bioresearch Foundation
2021
Steadman Clinic
2021
Hospital for Special Surgery
2021
University of Pittsburgh
2021
The purpose of this study was to characterize a tissue-engineered construct (TEC) generated with human synovial mesenchymal stem cells (MSCs). MSCs were cultured in medium ascorbic acid 2-phosphate (Asc-2P) and subsequently detached from the substratum. cell/matrix complex spontaneously contracted develop basic TEC. volume TEC assessed by varying initial cell density showed that it proportional densities up 4 × 105 cells/cm2. Assessment mechanical properties using custom device load at...
The aim of this study was to evaluate the effect human serum (HS) on growth and differentiation capacity synovium-derived mesenchymal stem cells (MSC) in comparison grown fetal bovine (FBS). Human MSCs were isolated from synovium knee joints three donors cultured individually varying concentrations allogenic HS or FBS. Bovine same manner. Cell proliferation assessed by tetrazolium assay after passage 3. for chondrogenic osteogenic investigated specific media followed 1,9-dimethylmethylene...
For an ideal osteochondral repair, it is important to facilitate zonal restoration of the subchondral bone and cartilage, layer by layer. Specifically, junction secure integration with adjacent cartilage could be considered key factors. The purpose present study was investigate feasibility a combined material comprising scaffold-free tissue-engineered construct (TEC) derived from synovial mesenchymal stem cells (MSCs) hydroxyapatite (HA) artificial using rabbit defect model. Osteochondral...
Background: Articular cartilage has limited healing capacity, owing in part to poor vascularity and innervation. Once injured, it cannot be repaired, typically leading high risk for developing osteoarthritis. Thus, cell-based and/or tissue-engineered approaches have been investigated; however, no approach yet achieved safety regenerative repair capacity via a simple implantation procedure. Purpose: To assess the efficacy of using scaffold-free construct (TEC) derived from autologous synovial...
Summary A population of mesenchymal stem cells, termed CXC chemokine ligand (CXCL)12‐abundant reticular (CAR) cells or leptin receptor‐expressing are the major cellular component niches for haematopoietic (HSCs) in murine bone marrow. CAR characterized by several salient features, including much higher expression CXCL12, cell factor (SCF), forkhead box C1 (FOXC1) and early B‐cell 3 (EBF3), which essential HSC maintenance, than other cells. However, human counterpart has not been fully...
Abstract Human small extracellular vesicles (sEVs) derived from adipose‐derived mesenchymal stromal cells (ASC) have been reported to suppress the progression of osteoarthritis (OA) in animal studies and subsequently, translation this potential assess their clinical efficacy is anticipated. However, fabrication protocols for sEVs eliminate contamination by culture medium‐derived components need be established prior use. The purpose present was elucidate influence contaminants on biological...
Because of its limited healing capacity, treatments for articular cartilage injuries are still challenging. Since the first report by Brittberg, autologous chondrocyte implantation has been extensively studied. Recently, as an alternative chondrocyte-based therapy, mesenchymal stem cell–based therapy received considerable research attention because relative ease in handling tissue harvest, and subsequent cell expansion differentiation. This review summarizes latest development therapies...
There are currently no disease-modifying treatments available for knee osteoarthritis (OA), although cultured adipose-derived stromal cells (ASCs) have shown promise in experimental models. However, given the regulatory limits on use of humans, previous trials focused primarily vascular fraction (SVF) intra-articular injection. Therefore, therapeutic value ASCs OA remains unknown.To study ASC versus SVF injection patients with Kellgren-Lawrence (KL) grades 2 to 4 parallel single-arm...
The present study investigated the surface structure and mechanical properties of repair cartilage generated from a tissue engineered construct (TEC) derived synovial mesenchymal stem cells at six months post-implantation compared to those uninjured cartilage.TEC-mediated was cartilaginous with Safranin O staining, had comparable macro-scale compressive cartilage.However, morphological assessments revealed that superficial zone TEC-mediated more fibrocartilage-like, in contrast middle or...
Pelvic sagittal inclination (PSI) significantly affects the femoral head coverage by acetabulum in patients with developmental dysplasia of hip (DDH), while no reports have quantified PSI DDH supine and standing positions. Furthermore, little is known about how changes after periacetabular osteotomies. Herein, positions was preoperatively postoperatively. Twenty-five who had undergone osteotomies were analyzed. The preoperative 2 years surgery measured using image registration technique...
Abstract Background It is important to understand the mode of transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for disease control. We aimed clarify how soon SARS-CoV-2 can occur after infection by asymptomatically infected individuals. Methods analyzed publicly available epidemiological information a cluster 108 cases 2019 (COVID-19) in Osaka, Japan. Results Among cases, 51 attended live music club only once and were considered have single visit. Ten remained...