A5041492235- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- HIV Research and Treatment
- Erythrocyte Function and Pathophysiology
- RNA Interference and Gene Delivery
- Hematological disorders and diagnostics
- interferon and immune responses
Osaka University
2021-2022
Osaka International University
2021
Ube Frontier University
2021
Kyoto University
2018
Summary A population of mesenchymal stem cells, termed CXC chemokine ligand (CXCL)12‐abundant reticular (CAR) cells or leptin receptor‐expressing are the major cellular component niches for haematopoietic (HSCs) in murine bone marrow. CAR characterized by several salient features, including much higher expression CXCL12, cell factor (SCF), forkhead box C1 (FOXC1) and early B‐cell 3 (EBF3), which essential HSC maintenance, than other cells. However, human counterpart has not been fully...
Abstract In bone marrow, special microenvironments, known as niches, are essential for the maintenance of hematopoietic stem cells (HSCs). A population mesenchymal cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) or leptin receptor-expressing major cellular component HSC niches. The molecular regulation niche properties is not fully understood. role Runx transcription factors, Runx1 and Runx2 in niches remains unclear. Here we show that predominantly expressed CAR mice...
Highly active antiretroviral therapy (HAART) has markedly prolonged the prognosis of HIV-1 patients. However, lifelong dependency on HAART is a continuing challenge, and an effective therapeutic much desired. Recently, introduction short hairpin RNA (shRNA) targeting promoter was found to suppress replication via transcriptional gene silencing (TGS). The technology expected be applied with hemato-lymphopoietic cell transplantation HIV patients transcription in transplanted cells. Combination...