A5004134827- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Functional Brain Connectivity Studies
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- Venous Thromboembolism Diagnosis and Management
- Multiple Sclerosis Research Studies
- Mental Health Research Topics
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
Hokkaido University
2022-2024
Abstract Dysregulation of Th17 and Treg cells contributes to the pathophysiology many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite, inhibits cell differentiation promotes by orchestrating metabolic epigenetic reprogramming. Mechanistically, itaconate suppresses glycolysis oxidative phosphorylation in Th17- Treg-polarizing T cells. Following treatment with S-adenosyl-L-methionine/S-adenosylhomocysteine ratio 2-hydroxyglutarate levels are decreased...
Abstract Objectives Pulmonary arterial hypertension associated with systemic sclerosis (PAH-SSc) sometimes accompanies pulmonary veno-occlusive disease (PVOD). We aimed to reveal the relationship between clinical signs of PVOD and severity vasculopathy in SSc. Methods This study included 52 consecutive SSc patients who had haemodynamic abnormalities [mean pressure (mPAP) >20 mmHg, vascular resistance >2 WU or artery wedge (PAWP) >15 mmHg]. A chest CT scan was evaluated...
Patients with Sjögren syndrome (SS) have a higher risk of developing malignant lymphoma.1A 68-year-old woman presented 2-month history swollen parotid glands. The patient had psoriatic arthritis and been treated secukinumab for 3 months.
Abstract Aberrant functional connectivity (FC) of the brain regions, evaluated by magnetic resonance imaging (fMRI), affects clinical courses in inflammatory arthritis (IA). The static analysis methods would be simplistic to estimate whole picture resting-state function because blood oxygen level-dependent (BOLD) signals fluctuate over time. effects FC dynamics on course are unknown IA. Therefore, we aimed evaluate dynamic for therapeutic responsiveness biologics IA patients. We analyzed...
ABSTRACT Aberrant resting-state static functional connectivity of the brain regions, which could be evaluated by magnetic resonance imaging (fMRI), affects clinical courses in inflammatory arthritis (IA) including rheumatoid and spondyloarthritis. This methods for assessing connections would too simple to estimate whole picture function because it fluctuates over time. The effects dynamics course are unknown patients with IA. Therefore, we aimed evaluate dynamic IA context therapeutic...