A5056272140- Geology and Paleoclimatology Research
- Functional Brain Connectivity Studies
- Isotope Analysis in Ecology
- Radioactive contamination and transfer
- Methane Hydrates and Related Phenomena
- Marine and coastal ecosystems
- Schizophrenia research and treatment
- Food Industry and Aquatic Biology
- Marine Biology and Ecology Research
- Advanced Neuroimaging Techniques and Applications
- Radioactive element chemistry and processing
- Mental Health Research Topics
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Marine and fisheries research
- Marine and environmental studies
- Radioactivity and Radon Measurements
- Geochemistry and Elemental Analysis
- Alzheimer's disease research and treatments
- Nuclear and radioactivity studies
- Advanced MRI Techniques and Applications
- Heart Failure Treatment and Management
- Geomagnetism and Paleomagnetism Studies
- Moyamoya disease diagnosis and treatment
- Dementia and Cognitive Impairment Research
Hokkaido University
2016-2025
Hokkaido University Hospital
2023-2025
Kishokai Medical Corporation
2025
Komatsu (Japan)
2025
Sapporo University
2024
Tokai University
2006-2022
Shimizu (Japan)
2005-2021
University of California, San Francisco
2014
Hakodate University
1994
Florida State University
1989
Subcortical structures, which include the basal ganglia and parts of limbic system, have key roles in learning, motor control emotion, but also contribute to higher-order executive functions. Prior studies reported volumetric alterations subcortical regions schizophrenia. Reported results sometimes been heterogeneous, few large-scale investigations conducted. Moreover, assessed asymmetries volumes Here, as a work completely independent study performed by ENIGMA consortium, we conducted...
Background and Purpose— The mechanisms underlying frontal lobe dysfunction in moyamoya disease (MMD) are unknown. We aimed to determine whether chronic ischemia induces subtle microstructural brain changes adult MMD evaluated the association of with neuropsychological performance. Methods— MRI, including 3-dimensional T1-weighted imaging diffusion tensor imaging, was performed 23 patients age-matched controls gray matter density major indices were compared between them; any alterations...
Abstract Differential diagnosis is sometimes difficult in practical psychiatric settings, terms of using the current diagnostic system based on presenting symptoms and signs. The creation a novel objective biomarkers expected to take place. Neuroimaging studies others reported that subcortical brain structures are hubs for various psycho-behavioral functions, while there so far no neuroimaging data-driven clinical criteria overcoming limitations system, which would reflect cognitive/social...
Abstract According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive (MDD), and autism spectrum (ASD) are classified based on symptoms. While its cluster of symptoms defines each these disorders, there is also an overlap in between disorders. We hypothesized that similarities differences cortical structural neuroimaging features among T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects...
Marine‐ and terrestrial‐derived biomarkers (alkenones, brassicasterol, dinosterol, long‐chain n ‐alkanes), as well carbonate, biogenic opal, ice‐rafted debris (IRD), were measured in two sediment cores the Sea of Okhotsk, which is located northwestern Pacific rim characterized by high primary productivity. Down‐core profiles phytoplankton markers suggest that productivity abruptly increased during global Meltwater Pulse events 1A (about 14 ka) 1B 11 stayed Holocene. Spatial temporal...
No neuroanatomical substrates for distinguishing between depression of bipolar disorder (dBD) and major depressive (dMDD) are currently known. The aim the current multicenter study was to identify patterns distinct depressed patients with two disorders. Further analysis conducted on an independent sample enable generalization results. We directly compared MR images these subjects using voxel-based morphometry (VBM) a support vector machine (SVM) algorithm 1531 participants. VBM showed...
The effect of duration illness and antipsychotic medication on the volumes subcortical structures in schizophrenia is inconsistent among previous reports. We implemented a large sample analysis utilizing clinical data from 11 institutions meta-analysis. Imaging 778 subjects were taken prospective meta-analysis conducted by COCORO consortium Japan. daily dose type antipsychotics assessed using linear mixed model where computed FreeSurfer used as dependent variable age, sex, illness,...
Abstract Background The bipolar disorder spectrum describes a continuum of symptoms comprising complex range subtypes which includes from purely depressive to manic symptoms. Modern psychiatric classifications have categorized this as mood disorders, often leading clinicians perceive and residing at opposite ends the spectrum. Some researchers believe that rather than changes, changes in energy motor activity are vital mania depression. This multi-dimensionality heterogeneity within pose...
The lateral longitudinal arch (LLA) is an essential structure of the foot. However, LLA evaluation methods remain underexplored compared to those medial (MLA). This study sought develop a method for measuring cuboid height, keystone LLA, using ultrasonography and verify its correlation with radiography, as well intrarater interrater reliability. cross-sectional included 21 university students (14 males seven females). height was measured radiography ultrasonography. validity ultrasonographic...
ABSTRACT One of the challenges in diagnosing psychiatric disorders is that results biological and neuroscience research are not reflected diagnostic criteria. Thus, data‐driven analyses incorporating cross‐disease perspectives, regardless category, have recently been proposed. A clustering study based on subcortical volumes 5604 subjects classified into four brain biotypes associated with cognitive/social functioning. Among identified controls patients schizophrenia, bipolar disorder, major...
Biogenic opal and ice‐rafted detritus (IRD) data from sediments in the Okhotsk Sea neighboring North Pacific revealed remarkable reduction production southward advancement of sea‐ice covered area during last glacial maximum, resulting also shift high biological productive northwestern Pacific. It implies that substantial outflux CO 2 to atmosphere pronounced increase sequestering temperate This could be an additional mechanism atmospheric period.
Since 1997, ocean color satellite images have revealed large‐scale blooms of the coccolithophorid Emiliania huxleyi in eastern Bering Sea. The are often sustained over several months and caused ecosystem changes Arctic Ocean, as well We examined continental shelf sediment profiles alkenone, a biomarker for E. , covering past ∼70 years. alkenone records suggest that large novel feature Sea they occurred only since late 1970s. Recent content were closely related to 1976–77 climatic regime...
Transport processes of particulate radiocesium were investigated using a sediment trap deployed at about 100 km east the Fukushima Daiichi Nuclear Power Plant. A was installed 873 m depth station (119 above bottom), and time-series sampling sinking particles carried out from August, 2011 to June, 2013. The accident-derived detected over two years after accident. Observed 137Cs flux highest in September (98 mBq m(-2) day(-1): decay-corrected March 11, 2011), decreased time with seasonal...
Abstract Objective Comorbid psychiatric disorders negatively affect the survival rate of patients with some physical disorders. In liver transplant recipients, various have been identified as worsening prognosis. However, little is known about how presence any comorbid (overall) recipients. this study, we examined effect overall on in Methods A total 1006 recipients who underwent transplantation between September 1997 and July 2017 across eight facilities a consultation-liaison team were...
Settling particles at 640 m, 1390 and 1920 m depths in the Okinawa Trough bottom sediments six sites East China Sea were analyzed for U Th isotopes, 210Pb, 210Po. Concentrations of 212Th settling higher than those observed open ocean relatively constant with depth compared other radiogenic nuclides. Fluxes concentrations these nuclides increased measured fluxes larger calculated from water column inventories. While sinking through 640-1390 increases 210Pb unsupported 228Th originating...
<h3>BACKGROUND AND PURPOSE:</h3> Detecting microstructural changes due to chronic ischemia potentially enables early identification of patients at risk cognitive impairment. In this study, diffusional kurtosis imaging and diffusion tensor were used investigate whether the former provides additional information regarding in gray white matter adult with Moyamoya disease. <h3>MATERIALS METHODS:</h3> MR (diffusional DTI) was performed 23 disease age-matched controls. Three parameters extracted...