A5070363441- Functional Brain Connectivity Studies
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Behavioral and Psychological Studies
- Mental Health Research Topics
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Obsessive-Compulsive Spectrum Disorders
- Blind Source Separation Techniques
- Schizophrenia research and treatment
- Psychology of Moral and Emotional Judgment
- Child and Animal Learning Development
- Neurobiology of Language and Bilingualism
- Spectroscopy and Chemometric Analyses
- Advanced Memory and Neural Computing
- Cerebral Palsy and Movement Disorders
- Neuroscience and Neuropharmacology Research
- Aging and Gerontology Research
- Electrochemical Analysis and Applications
- Speech and Audio Processing
- Treatment of Major Depression
Showa University
2016-2025
Tokyo Medical and Dental University
2024
Tohoku University
2024
Showa University Karasuyama Hospital
2014-2021
Showa University Hospital
2020
Centre for Addiction and Mental Health
2016
Kyushu Institute of Technology
2009-2011
When collecting large amounts of neuroimaging data associated with psychiatric disorders, images must be acquired from multiple sites because the limited capacity a single site. However, site differences represent barrier when acquiring multisite data. We utilized traveling-subject dataset in conjunction multisite, multidisorder to demonstrate that are composed biological sampling bias and engineering measurement bias. The effects on resting-state functional MRI connectivity based pairwise...
Recent functional magnetic resonance imaging (fMRI) studies on autism spectrum condition (ASC) have identified dysfunctions in specific brain networks involved social and non-social cognition that persist into adulthood. Although increasing numbers of fMRI revealed atypical connectivity the adult ASC brain, such alterations at network level not yet been fully characterized within recently developed graph-theoretical framework. Here, we applied a analysis to resting-state data acquired from...
Abstract Machine learning classifiers for psychiatric disorders using resting-state functional magnetic resonance imaging (rs-fMRI) have recently attracted attention as a method directly examining relationships between neural circuits and disorders. To develop accurate generalizable classifiers, we compiled large-scale, multi-site, multi-disorder neuroimaging database. The database comprises fMRI structural images of the brain from 993 patients 1,421 healthy individuals, well demographic...
Many studies have highlighted the difficulty inherent to clinical application of fundamental neuroscience knowledge based on machine learning techniques. It is difficult generalize brain markers data acquired from independent imaging sites, mainly due large site differences in functional magnetic resonance imaging. We address finding a generalizable marker major depressive disorder (MDD) that would distinguish patients healthy controls resting-state connectivity patterns. For discovery...
Objective: To investigate shared and specific neural correlates of cognitive functions in attention deficit hyperactivity disorder (ADHD) autism spectrum (ASD), the authors performed a comprehensive meta-analysis considered balanced set neuropsychological tasks across two disorders. Methods: A broad electronic databases was searched up to December 4, 2022, for task-based functional MRI studies investigating differences between individuals with ADHD or ASD typically developing control...
Previous autism research has hypothesized that abnormalities of functional connectivity in spectrum disorder (ASD) may vary with the spatial distance between two brain regions. Although several resting-state magnetic resonance imaging (rsfMRI) studies have extensively examined long-range (or distant) adult ASD brain, short-range local) been investigated less depth. Furthermore, possible relationship and activity level during resting state remains unclear.We acquired rsfMRI data from 50...
Growing evidence suggests that a broad range of behavioral anomalies in people with autism spectrum disorder (ASD) can be linked morphological and functional alterations the brain. However, neuroanatomical underpinnings ASD have been investigated using either structural magnetic resonance imaging (MRI) or diffusion tensor (DTI), relationships between abnormalities revealed by these two modalities remain unclear. This study applied multimodal data-fusion method, known as independent component...
Abstract Differential diagnosis is sometimes difficult in practical psychiatric settings, terms of using the current diagnostic system based on presenting symptoms and signs. The creation a novel objective biomarkers expected to take place. Neuroimaging studies others reported that subcortical brain structures are hubs for various psycho-behavioral functions, while there so far no neuroimaging data-driven clinical criteria overcoming limitations system, which would reflect cognitive/social...
Abstract According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia (SZ), bipolar disorder (BD), major depressive (MDD), and autism spectrum (ASD) are classified based on symptoms. While its cluster of symptoms defines each these disorders, there is also an overlap in between disorders. We hypothesized that similarities differences cortical structural neuroimaging features among T1-weighted magnetic resonance imaging scans were performed for 5,549 subjects...
Although the ability to make optimal decisions under uncertainty is an integral part of everyday life, individuals with autism spectrum disorder (ASD) frequently report that they experience difficulties this skill. In behavioral economics, researchers distinguish two types understand decision-making in setting: risk (known probabilities) and ambiguity (unknown probabilities). However, it remains unclear how ASD behave ambiguity, despite growing evidence their altered uncertainty. We...
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity (ADHD) have high rates of co-occurrence share atypical behavioral characteristics, including sensory symptoms. The present diffusion tensor imaging (DTI) study was conducted to examine whether how white matter alterations are observed in adult populations with developmental disorders (DD) determine brain-sensory relationships either shared between or distinct ASD ADHD.We collected DTI data from population DD (a primary...
Abstract Increased excitatory neuronal tones have been implicated in autism, but its mechanism remains elusive. The amplified glutamate signals may arise from enhanced glutamatergic circuits, which can be affected by astrocyte activation and suppressive signaling of dopamine neurotransmission. We tested this hypothesis using magnetic resonance spectroscopy positron emission tomography scan with 11 C-SCH23390 for D1 receptors the anterior cingulate cortex (ACC). enrolled 18 male adults...
The insular cortex comprises multiple functionally differentiated sub-regions, each of which has different patterns connectivity with other brain regions. Such diverse are thought to underlie a wide range functions, including cognitive, affective, and sensorimotor processing, many abnormal in autism spectrum disorder (ASD). Although past neuroimaging studies ASD have shown structural functional abnormalities the insula, possible alterations sub-regional organization insula characteristics...
Atypical sensory responses and seeking behaviors constitute the core symptoms of autism spectrum condition (ASC). There are possible links between atypical profiles attentional challenges in ASC. Due to paucity studies adults, nature their associations with autistic adults remain elusive. Here, we investigated sustained attention performance its 28 adult males 23 typically developing controls (TDCs). A gradual-onset continuous task Adolescent/Adult Sensory Profile were employed assess...
Abstract Autobiographic remembering often involves types of constructive processes for psychological experiences and hypothetical scenarios past events. Previous research revealed a range phenomenological functional characteristics associated with recalls episodes high autobiographical significance. However, neural bases such their association memory construction remain unclear. In this magnetic resonance imaging study, we collected from 28 young adults extensive metrics related to We then...
Functions of the orbitofrontal cortex include diverse social, cognitive and affective processes, many which are abnormal in autism spectrum disorders (ASDs).Recently, altered sulcogyral patterns have been revealed several psychiatric conditions, such as schizophrenia, indicating a possibility that morphology reflects neurodevelopment.However, presence sulcal alterations ASD remains unexplored.Using structural magnetic resonance imaging, subtypes H-shaped sulcus (Type I, II III, order...
Abstract Intergroup bias, which is the tendency to behave more positively toward an in‐group member than out‐group member, pervasive in real life. In particular, intergroup bias trust decisions substantially influences multiple areas of life and thus better understanding this can provide significant insights into human social behavior. Although previous functional magnetic resonance imaging studies showed involvement right temporoparietal junction (TPJ) a causal relationship between two has...
Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline (NA) neurotransmissions in autism spectrum disorder (ASD) pathophysiology, few examined these individuals with ASD vivo. Here, we investigated DA D1 receptor (D1R) transporter (NAT) binding adults (n = 18) neurotypical controls 20) by utilizing two different PET radioligands, [11C]SCH23390 (S,S)-[18F]FMeNER-D2, respectively. We found no significant group differences D1R (striatum, anterior cingulate...
Individuals with autism spectrum conditions (ASCs) often experience difficulty and confusion in acknowledging others' perspectives arguably exhibit egocentricity. However, whether this egocentricity necessarily results selfish behavior during social situations remains a matter of debate. To study relationship, we used computerized visuospatial perspective‐taking task (VPT) social‐discounting (SDT), derived from cognitive psychology behavioral economics, examined egocentric other‐oriented...