A5026536764- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Autism Spectrum Disorder Research
- Advanced MRI Techniques and Applications
- Mental Health Research Topics
- Schizophrenia research and treatment
- Neural and Behavioral Psychology Studies
- Attention Deficit Hyperactivity Disorder
- EEG and Brain-Computer Interfaces
- Treatment of Major Depression
- Transcranial Magnetic Stimulation Studies
- HIV Research and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Psychosomatic Disorders and Their Treatments
- Alzheimer's disease research and treatments
- Electroconvulsive Therapy Studies
- Memory and Neural Mechanisms
- HIV-related health complications and treatments
- Tryptophan and brain disorders
- Heart Rate Variability and Autonomic Control
- Nicotinic Acetylcholine Receptors Study
- Technology and Human Factors in Education and Health
- Aldose Reductase and Taurine
Kyoto University
2016-2025
Advanced Telecommunications Research Institute International
2017
National Institutes for Quantum Science and Technology
2017
Tokyo Metropolitan University
2017
Hiroshima University
2017
The University of Tokyo
2017
Showa University
2017
eBay (Ireland)
2012
Hamamatsu Medical Center
2012
Koujin Hospital
2011
<h3>Context</h3>A growing body of evidence suggests that aberrant immunologic systems underlie the pathophysiologic characteristics autism spectrum disorder (ASD). However, to our knowledge, no information is available on patterns distribution microglial activation in brain ASD.<h3>Objectives</h3>To identify regions associated with excessively activated microglia whole brain, and examine similarities pattern subjects ASD control subjects.<h3>Design</h3>Case-control study using positron...
Accumulating evidence suggests that dysregulation of the immune system is involved in pathophysiology autism spectrum disorders (ASD). The aim study was to explore immunological markers peripheral plasma samples from non-medicated subjects with high-functioning ASD.A multiplex assay for cytokines and chemokines applied male ASD (n = 28) matched controls 28). Among a total 48 analytes examined, concentrations IL-1β, IL-1RA, IL-5, IL-8, IL-12(p70), IL-13, IL-17 GRO-α were significantly higher...
When collecting large amounts of neuroimaging data associated with psychiatric disorders, images must be acquired from multiple sites because the limited capacity a single site. However, site differences represent barrier when acquiring multisite data. We utilized traveling-subject dataset in conjunction multisite, multidisorder to demonstrate that are composed biological sampling bias and engineering measurement bias. The effects on resting-state functional MRI connectivity based pairwise...
Abstract Machine learning classifiers for psychiatric disorders using resting-state functional magnetic resonance imaging (rs-fMRI) have recently attracted attention as a method directly examining relationships between neural circuits and disorders. To develop accurate generalizable classifiers, we compiled large-scale, multi-site, multi-disorder neuroimaging database. The database comprises fMRI structural images of the brain from 993 patients 1,421 healthy individuals, well demographic...
Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality a continuum explained by neural mechanism shared across or set of discrete dysfunctions. Here, we performed predictive modeling to examine working ability (WMA) as function normative whole-brain connectivity psychiatric diseases. We built quantitative model for letter three-back task performance healthy participants, using...
Abstract Depressive disorders contribute heavily to global disease burden; This is possibly because patients are often treated homogeneously, despite having heterogeneous symptoms with differing underlying neural mechanisms. A novel treatment that can directly influence the circuit relevant an individual patient’s subset of might more precisely and thus effectively aid in alleviation their specific symptoms. We tested this hypothesis a proof-of-concept study using fMRI functional...
Abstract The limited efficacy of available antidepressant therapies may be due to how they affect the underlying brain network. purpose this study was develop a melancholic MDD biomarker identify critically important functional connections (FCs), and explore their association treatments. Resting state fMRI data 130 individuals (65 major depressive disorder (MDD) patients, 65 healthy controls) were included build classifier, 10 FCs selected by our sparse machine learning algorithm. This...
Abstract Background and Hypothesis Dynamics of the distributed sets functionally synchronized brain regions, known as large-scale networks, are essential for emotional state cognitive processes. However, few studies were performed to elucidate aberrant dynamics across networks multiple psychiatric disorders. In this paper, we aimed investigate dynamic aspects aberrancy causal connections among Study Design We applied modeling (DCM) large-sample multi-site dataset with 739 participants from 4...
The habenula is involved in the pathophysiology of depression. However, its small structure limits accuracy segmentation methods, and findings regarding volume have been inconsistent. This study aimed to create a highly accurate model using deep learning, test generalizability clinical magnetic resonance imaging, examine changes healthy participants patients with multicenter included 382 (patients depression: n=234, women 47.0%; participants: n=148, 37.8%). A three-dimensional Residual U-Net...
Although the relationship between schizophrenia spectrum disorder (SSD) and autism (ASD) has long been debated, it not yet fully elucidated. The authors quantified visualized ASD SSD using dual classifiers that discriminate patients from healthy controls (HCs) based on resting-state functional connectivity magnetic resonance imaging. To develop a reliable classifier, sophisticated machine-learning algorithms automatically selected SSD-specific connections were applied to Japanese datasets...
<title>Abstract</title> Exploring the neurobiological effects of various treatments for depression is pivotal in elucidating shared and unique mechanisms action that may explain commonalities differences treatment outcomes. The amygdala, consisting subdivisions with distinct roles emotional processing, thought to be implicated pathophysiology depression. However, how alter nuclei-specific resting-state functional connectivity (rs-FC) amygdala remains unclear. Here, we hypothesized restore...
Abstract Background Methamphetamine-induced psychosis (MIP) is characterized by transient episodes, but a substantial portion persists long-term (Wearne &Cornish 2018). While symptom similarities exist between MIP and schizophrenia (Sz), their neural correlates remain uncertain. Furthermore, research into the basis underlying presence duration of has been limited. Aims & Objectives This study aimed to investigate whether there would be differences in discriminatory ability when...
Research on biomarkers for predicting psychiatric disorders from resting-state functional connectivity (FC) is advancing. While the focus has primarily been discriminative performance of by machine learning, identification abnormal FCs in often treated as a secondary goal. However, it crucial to investigate effect size and robustness selected because they can be used potential targets neurofeedback training or transcranial magnetic stimulation therapy. Here, we incorporated approximately...
Investigation into the whole brain morphology of early onset schizophrenia (EOS) to date has been sparse. We studied regional volumes in EOS patients, and correlations between volume measures symptom severity.A total 18 patients (onset under 16 years) controls matched for age, gender, parental socioeconomic status, height were examined. Voxel-based morphometric analysis using Brain Analysis Morphological Mapping (BAMM) software package was employed explore alterations grey (GM) white matter...
It is still unclear why some early Parkinson disease (PD) patients with unilateral parkinsonism develop bilateral soon after the diagnosis made as Hoehn and Yahr (HY) stage 1 others remain stable for a long time. Here, we examined in vivo changes brain dopaminergic system using PET dopamine transporter radiotracer, <sup>11</sup>C-2-B-carbomethoxy-3B-(4-fluorophenyl) tropane (<sup>11</sup>C-CFT), to elucidate pathophysiologic characteristics of converters. <b>Methods:</b> Twelve drug-naïve PD...
Abstract Resting-state functional connectivity (rsFC) is increasingly used to develop biomarkers for psychiatric disorders. Despite progress, development of the reliable and practical FC biomarker remains an unmet goal, particularly one that clinically predictive at individual level with generalizability, robustness, accuracy. In this study, we propose a new approach profile each from diverse perspective, encompassing not only disorder-related differences but also disorder-unrelated...
<h3>Context</h3> Both neuropsychological and functional magnetic resonance imaging studies have shown deficiencies in face perception subjects with autism spectrum disorders (ASD). The fusiform gyrus has been regarded as the key structure perception. cholinergic system is known to regulate function of visual pathway, including gyrus. <h3>Objectives</h3> To determine whether central acetylcholinesterase activity, a marker for system, altered ASD alteration if any, correlated their social...
Increasing evidence suggests that psychiatric disorders are linked to alterations in the mesocorticolimbic dopamine-related circuits. However, common and disease-specific remain be examined schizophrenia (SCZ), major depressive disorder (MDD), autism spectrum (ASD). Thus, this study aimed examine features related
Brain β-amyloid (Aβ) deposition during normal aging is highlighted as an initial pathogenetic event in the development of Alzheimer's disease. Many recent brain imaging studies have focused on areas deactivated cognitive tasks [the default mode network (DMN), i.e., medial frontal gyrus/anterior cingulate cortex and precuneus/posterior cortex], where strength functional coordination was more or less affected by cerebral Aβ deposits. In present positron emission tomography study, to...
Team sports activities are effective for improving the negative symptoms and cognitive functions in patients with schizophrenia. However, interpersonal coordination during visual cognition of schizophrenia who have team habits unknown. The main objectives this study were to test two hypotheses: first, perform skill requiring ball passing receiving worse than healthy controls; second, will be impaired these functionings accordance previous studies regarding general. Twelve 15 controls, had...