A5070977608- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- DNA Repair Mechanisms
- Prenatal Screening and Diagnostics
- Sperm and Testicular Function
- DNA and Nucleic Acid Chemistry
- Schizophrenia research and treatment
- Reproductive Health and Technologies
- Functional Brain Connectivity Studies
- Reproductive System and Pregnancy
- Action Observation and Synchronization
- Electronic Packaging and Soldering Technologies
- Advanced Neuroimaging Techniques and Applications
- Endometriosis Research and Treatment
- Carcinogens and Genotoxicity Assessment
- Dental Radiography and Imaging
- Sexual Differentiation and Disorders
- Bacterial Genetics and Biotechnology
- Healthcare professionals’ stress and burnout
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nutrition, Genetics, and Disease
- Robot Manipulation and Learning
- Glycosylation and Glycoproteins Research
- Social Robot Interaction and HRI
Tokyo Medical and Dental University Hospital
2023
Kyoto University
1998-2022
Tokyo Medical and Dental University
2020-2022
Kobe Medical Center
2020-2021
Kobe Women's University
2010-2020
Health Sciences University of Hokkaido
2015
Chiba University
2010
Kanagawa Dental University
2004-2009
Tokyo Metropolitan University
2008-2009
Nara Institute of Science and Technology
2003-2007
Although the relationship between schizophrenia spectrum disorder (SSD) and autism (ASD) has long been debated, it not yet fully elucidated. The authors quantified visualized ASD SSD using dual classifiers that discriminate patients from healthy controls (HCs) based on resting-state functional connectivity magnetic resonance imaging. To develop a reliable classifier, sophisticated machine-learning algorithms automatically selected SSD-specific connections were applied to Japanese datasets...
Piezo-assisted intracytoplasmic sperm injection (Piezo-ICSI) is reported to be an effective method for inseminating fragile oocytes compared with conventional ICSI (c-ICSI). However, infertile patient groups suitable Piezo-ICSI have not been elucidated. This study was conducted determine age using sibling egg controls inseminated by a well-trained embryologist reduce technical inequalities.A total of 947 matured were either or c-ICSI in as controls. Fertilization (2 pronuclei, PN), survival,...
Abstract Aim To determine whether there are differences in size between the male and female pronuclei immediately before pronuclear membrane breakdown ( PNMBD ) to evaluate influence normal birth rates. Methods Time‐lapse photography was used measure of each pronucleus, while outcome 71 frozen‐thawed single blastocyst transfers patients receiving hormone therapy analyzed retrospectively. The measurements were made 4 hours , corresponding 16‐20 after insemination or intracytoplasmic sperm...
To evaluate the effectiveness of high-dose progesterone supplementation for women who are undergoing a frozen-thawed embryo transfer (FET).Among 2010 FET cycles that were included in present study, 1188 1200 mg/d vaginal progesterone, while 822 900 mg/d. The dose was used decided by treatment period and additional when serum levels <9 ng/mL on luteal day 5.The clinical pregnancy rate higher mg group than group. mean level 5 groups 12.6 13.4 ng/mL, respectively. A logistic regression analysis...
COVID-19 has caused the collapse of medical systems in metropolitan areas around world. Medical personnel are at high risk mental health problems.1 Furthermore, they also susceptible to deterioration human relations and income reduction due fear contagion stigma.2-6 Some have been encouraged by their families quit jobs, some avoided others occupations, prevented from working multiple facilities, thus leading financial burdens. Such situations negatively influenced motivation towards work....
5-Formyluracil (5-foU) is a potentially mutagenic lesion of thymine produced in DNA by ionizing radiation and various chemical oxidants. Although 5-foU has been reported to be removed from <i>Escherichia coli</i> AlkA protein <i>in vitro</i>, its repair mechanisms are not fully understood. In this study, we used the borohydride trapping assay detect characterize activities for <i>E. extracts with site-specifically designed oligonucleotides containing at defined sites. The revealed that there...
Prior 8-week treatment with menatetrenone, MK-4, followed by risedronate prevented the shortcomings of individual drugs and significantly increased strength ovariectomized ICR mouse femur compared to (OVX) controls. Neither MK-4 following nor concomitant administration may be recommended because they brought least beneficial effect. The objective this study was determine best combinatory at 0.25 mg/kg/day (R) vitamin K2 approximately 100 μg MK-4/kg/day (K) improve osteoporotic bone....
Multiple rounds of centrifugation or washing spermatozoa can cause sperm DNA fragmentation (SDF); however, a microfluidic approach to select does not require centrifugation. Reports have suggested that sorting using device is an effective method good quality spermatozoa, it known whether reduces damage. We investigated the frequency SDF was affected by selection during processing.Semen samples from ten men with normal, oligozoospermia and asthenozoospermia were split into two groups sorted...
Abstract Aim To evaluate whether local endometrial injury would improve the pregnancy rates after frozen‐thawed blastocyst transfer in cycles with hormone replacement. Methods Seventy‐seven patients who were aged <40 years a history of at least three unsuccessful embryo transfers and underwent during replacement between February June, 2013 studied. They allocated into two groups based on last digit their clinical record number: an experimental group (n=22), excluding withheld consent or...
Abstract Objectives Schizophrenia is a mental illness that presents with thought disorders including delusions and disorganized speech. Thought have been regarded as consequence of the loosening associations between semantic concepts since term “schizophrenia” was first coined by Bleuler. However, mechanistic account this cardinal disturbance in terms functional dysconnection has lacking. To evaluate how aberrant connections are expressed through brain activity, we characterized large-scale...
Team sports activities are effective for improving the negative symptoms and cognitive functions in patients with schizophrenia. However, interpersonal coordination during visual cognition of schizophrenia who have team habits unknown. The main objectives this study were to test two hypotheses: first, perform skill requiring ball passing receiving worse than healthy controls; second, will be impaired these functionings accordance previous studies regarding general. Twelve 15 controls, had...
Abstract Recent studies examining electroconvulsive therapy (ECT) have reported that early sessions can induce rapid antidepressant and antipsychotic effects, the termination of ECT was to increase risk relapse. We hypothesized different neural mechanisms associated with therapeutic effects may be involved in responses observed during late periods treatment. investigated whether these were temporally spatially regional gray matter volume (GMV) changes ECT. Fourteen patients major depressive...
It is widely known that there a high prevalence of cigarette smoking in schizophrenia. One the explanations self-medication hypothesis. Based on this hypothesis, it has been suggested nicotine procognitive effect or even neuroprotective However, cigarettes contain numerous neurotoxic substances, making net brain function and structure complex. Indeed, recent studies have called into question We aimed to test whether an interaction between diagnosis status gray matter volume, ie, specific...
Schizophrenia patients have impairments of biological motion (BM) perception, which provides critical information about social cognition. Because cognition is underpinned by attention, the BM perception in schizophrenia could be partially attributable to altered attention. To elucidate attention and schizophrenia, we investigated neural basis impaired processing using MRI respect deficits eye tracker. Voxel-based morphometry was performed evaluate relationship between gray matter (GM)...
Abstract Purpose To evaluate the outcomes of embryo transfer (ET) and to identify parameters influencing pregnancy outcomes. Methods This study included 938 ET cycles involving single frozen thawed good‐quality blastocyst (Gardner grade ≥3BB) between August 2017 January 2018. The significance several including endometrial thickness, position transferred air bubble, self‐evaluation score by physicians, uterus direction at as predictors clinical was evaluated using univariate multivariate...
Abstract Schizophrenia patients often manifest semantic processing deficits. It has been proposed that these deficits stem from disorganized representations in the brain. However, no study yet examined neural correlates of disorganization by directly evaluating We used voxelwise modeling on functional magnetic resonance imaging signals to evaluate associated with several thousand words individual patient brains. then compared structural properties those healthy controls. The variability was...
In this study, microelectron beam welding was applied to the joining of two thin metal foils. An electron is adaptable microwelding due its deep penetration and width. The foil materials used were SUS Ti with a thickness 20 µm. relationship between input energy irradiation size heat affected zone investigated. Furthermore, spot overlap carried out for foils either same or dissimilar materials. surface cross section welded observed by scanning microscope (SEM) confocal laser (CLSM). case...
Abstract Aim Human chorionic gonadotropin ( hCG ) is used frequently for luteal support in fresh vitro fertilization cycles as it induces progesterone secretion from the ovaries after oocyte retrieval and modulates endometrium implantation cycles. In contrast, not usually transfer of cryopreserved‐thawed embryos estrogen/progesterone replacement because ovulation suppressed. However, several studies have shown that luteinizing hormone receptors are present human can directly induce...
Abstract Aim Several studies have indicated that the cause of increased birthweight frozen‐thawed embryos was associated with assisted reproductive technology ( ART ) procedures, such as cryopreservation. In present study, mean singletons compared between ovulatory and hormone replacement therapy HRT cycles in order to investigate primary factor leads higher birthweights from embryo transfer FET ). Methods This retrospective study carried out January 2011 December 2014 on 2738 who were born...