A5101469479- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Crystallography and molecular interactions
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Urinary Bladder and Prostate Research
- Cancer Research and Treatments
- Radiopharmaceutical Chemistry and Applications
- Renal and related cancers
- Amino Acid Enzymes and Metabolism
- Treatment of Major Depression
- Hormonal and reproductive studies
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Testicular diseases and treatments
- Ultrasound and Hyperthermia Applications
- Minimally Invasive Surgical Techniques
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
Anjo Kosei Hospital
2015-2025
Japan Clinical Cancer Research Organization
2018
Nagoya City University
1993-2014
Mizuho (Japan)
2014
National Hospital Organization Kyushu Cancer Center
2013
Dokkyo Medical University
2013
Fujita Health University
2013
Sendai Kousei Hospital
2007-2008
Osaka Medical and Pharmaceutical University
1989-2006
Osaka Hospital
2006
The optimal dose of intravesical bacillus Calmette-Guérin for the treatment nonmuscle invasive bladder cancer is controversial. We investigated if induction therapy with low could achieve a complete response rate similar to that standard Calmette-Guérin, less toxicity and higher quality life.After transurethral resection, patients unresectable multiple and/or carcinoma in situ were randomized receive (80 mg) or (40 instillation (weekly, 8 times). primary end point was noninferiority null...
ABSTRACT Background Clinical trials rarely focus on elder patients with castration‐resistant prostate cancer (CRPC), and data the outcomes of second‐generation androgen receptor signaling inhibitors (ARSIs) remain limited. Methods The ENABLE study for was an investigator‐initiated, multicenter, randomized controlled trial conducted in Japan to compare enzalutamide (ENZ) abiraterone plus prednisolone (ABI). This sub‐analysis performed evaluate efficacy safety profiles between aged ≥ 75...
Abstract BACKGROUND Our previous study clearly demonstrated that decreased expression of prothymosin alpha (PTMA) was associated with inhibition rat prostate carcinogenesis by isoflavones. The purpose the present investigation to provide a better understanding role PTMA in human cancers. METHODS AND RESULTS 68 cancer cases and cell lines examined immunohistochemistry immunoblotting, its levels were increased progression from normal epithelium, through prostatic intraepithelial neoplasia...
The effects of intravesical instillation Adriamycin (doxorubicin) (ADR), and mitomycin C (MMC), as inhibitors development rat bladder tumors, were examined in rats treated with N-butyl-N-(4-hydroxybuty1)nitrosamine (BBN). Intravesical ADR or MMC once a week for 12 weeks into pretreated BBN 4 markedly enhanced tumors. That is, one after the end these compounds incidence papillary nodular hyperplasias, namely preneoplastic lesions, was significantly increased, at experiment not only...
This multicenter, phase II clinical trial evaluated the diagnostic performance of 18F-fluciclovine, a novel amino acid for positron-emission tomography (PET), detection small lymph node metastases with short-axis diameters 5-10 mm in patients prostate cancer.Patients cancer were eligible after screening laboratory tests and pelvic contrast-enhanced computed (CT). Pelvic region 18F-fluciclovine PET/CT was then acquired within 28 days dissection regional nodes performed 60 CT. Diagnostic...
Enzalutamide (ENZ) and abiraterone plus prednisolone (ABI) can improve the survival of patients with castration-resistant prostate cancer (CRPC). However, agent that is more effective against nonmetastatic CRPC remains unclear. To evaluate be used as first-line treatment for CRPC, an investigator-initiated, multicenter, randomized controlled trial (ENABLE Study PCa) including both metastatic was conducted in Japan. The prostate-specific antigen (PSA) response rate, overall survival, some...
Abstract The nature of post‐ictal headache (PIH) remains unclear. A multicenter study was conducted in order to evaluate frequency and risk factors for PIH. subjects consisted 97 patients with temporal lobe epilepsy (TLE), 65 frontal (FLE) 37 occipital (OLE). were asked about PIH at each institute. Clinical reviewed patient correlated Post‐ictal occurred 41% TLE patients, 40% FLE 59% OLE patients. Logistic regression analysis revealed that the significantly higher than FLE. In contrast,...
Osteopontin (OPN), a secreted adhesive glycoprotein, has been shown to be produced in excessive amounts variety of experimental models malignancy. Increased levels OPN exist blood from the lungs, breasts, and gastrointestinal tracts cancer patients with metastases. However, there have no reports on expression human urological malignancies. The present study investigates presence adenocarcinoma prostate benign prostatic hyperplasia (BPH).Using tissue 34 primary cancer, 13 after having...
Enzalutamide (ENZ) and abiraterone plus prednisolone (ABI) improve survival in castration-resistant prostate cancer (CRPC). However, which agent is better for patients with CRPC remains unclear.To evaluate whether ENZ or ABI as first-line treatment CRPC.An investigator-initiated, multicenter, randomized controlled trial was conducted Japan. The study enrolled 203 before chemotherapy between February 20, 2015, July 31, 2019. Patients were randomly assigned 1:1 to the arm.The primary endpoint...
We attempted to determine a target of chemotherapy specific glioblastoma cells ensure favorable response anticancer drugs, through comparison in biologic nature related drug resistance with other types cancer cells. Using 13 human cell lines including 3 lines, gene expression analysis and biochemical quantitative assay were performed for total 12 properties, which have been linked action. Although most genes resistance, such as MDR1, MRP, MGMT GSTpi, overexpressed T98G, U-373MG, U-251MG...
Team sports activities are effective for improving the negative symptoms and cognitive functions in patients with schizophrenia. However, interpersonal coordination during visual cognition of schizophrenia who have team habits unknown. The main objectives this study were to test two hypotheses: first, perform skill requiring ball passing receiving worse than healthy controls; second, will be impaired these functionings accordance previous studies regarding general. Twelve 15 controls, had...
No AccessJournal of UrologyClinical Urology: Original Article1 Sep 1996Clinicopathological Evaluation Repeated Courses Intravesical Bacillus Calmette-Guerin Instillation for Preventing Recurrence Initially Resistant Superficial Bladder Cancer Takehiko Okamura, Keiichi Tozawa, Yasuyuki Yamada, Hiroshi Sakagami, Kousuke Ueda, and Kenjiro Kohri OkamuraTakehiko Okamura More articles by this author , TozawaKeiichi Tozawa YamadaYasuyuki Yamada SakagamiHiroshi Sakagami UedaKousuke Ueda KohriKenjiro...
Objectives . Primary mediastinal germ cell tumors (PMGCTs) are rare, which often makes them difficult to treat. Herein, we examined patients with PMGCTs who underwent multimodal treatment. Methods We 6 (median age: 25 years, range: 19–27 years) treatment between April 2001 and March 2015. Three had seminomas, 2 yolk sac tumors, 1 patient choriocarcinoma. The median observation period was 32.5 months (range: 8–84 months). Results of the received initial operation followed by 3-4 courses...
To develop a set of process-of-care quality indicators (QIs) that would cover wide range gastric cancer care modalities and to examine the current state provided by designated hospitals in Japan.A retrospective medical record review.Eighteen throughout total 1685 patients diagnosed with 2007.Provision eligible as described 29 QIs, which were developed using an adaptation RAND/UCLA (University California, Los Angeles) appropriateness method panel nationally recognized experts Japan.Overall,...
Abstract Background A head‐to‐head comparison between enzalutamide (ENZ) and abiraterone plus prednisolone (ABI) revealed similar survival benefits for castration‐resistant prostate cancer (CRPC) in the ENABLE study PCa. Considering that a dose reduction of ENZ ABI has demonstrated sufficient inhibitory ability androgen receptor (AR) signaling, we analyzed efficacy modified doses these agents Methods This investigator‐initiated, multicenter, randomized controlled trial was conducted Japan...
Pathological mechanisms of "long COVID" after recovery from the main symptoms COVID-19 are unclear. We compared psychological differences between individuals with and without long COVID initial infections.
The purpose of this study was to assess the efficacy Bacillus Calmette-Guerin (BCG) therapy after a second transurethral resection (TUR) in new onset high-grade T1 bladder cancer.From January 2008 September 2013, 207 patients with cancer an initial TUR were treated at our university and affiliated hospitals. Residual rate, intravesical recurrence-free survival (RFS), risk factors for recurrence analyzed.Among total patients, 42 BCG following (group 1), 23 alone 2), 72 3), 70 without or BCG....