A5064368434- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Axon Guidance and Neuronal Signaling
- Connexins and lens biology
- Nerve injury and regeneration
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Signaling Pathways in Disease
- Stress Responses and Cortisol
- Neonatal and fetal brain pathology
- Circadian rhythm and melatonin
- RNA regulation and disease
- Neurotransmitter Receptor Influence on Behavior
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Autism Spectrum Disorder Research
- Vascular Malformations Diagnosis and Treatment
- Vestibular and auditory disorders
- Intracranial Aneurysms: Treatment and Complications
- Nicotinic Acetylcholine Receptors Study
Nagoya City University
2015-2025
Mizuho (Japan)
2001-2024
Ehime University Hospital
2023
Hamamatsu University School of Medicine
2004-2017
Suzuki (Japan)
2014
Chukyo University
2014
Hirosaki University
2014
RIKEN Center for Brain Science
2014
Hamamatsu University
2010-2011
Nagoya University
1994-2009
Methamphetamine is a popular addictive drug whose use associated with multiple neuropsychiatric adverse events and toxic to the dopaminergic serotonergic systems of brain. Methamphetamine-induced neuropathology increased expression microglial cells that are thought participate in either pro-toxic or protective mechanisms Although reactive microgliosis has been observed animal models methamphetamine neurotoxicity, no study reported on status activation human abusers. The present reports 12...
Caloric restriction (CR) is known to retard aging and delay functional decline as well the onset of diseases in most organisms. Ghrelin secreted from stomach response CR regulates energy metabolism. We hypothesized that ghrelin has a role protecting aging-related diseases. examined physiological mechanisms underlying system during process three mouse strains with different genetic biochemical backgrounds animal models accelerated or normal human aging. The elevated plasma concentration was...
Abstract DNA double-strand break (DSB) is the most severe form of damage and accumulates with age, in which cytoskeletal proteins are polymerized to repair DSB dividing cells. Since tau a microtubule-associated protein, we investigate whether involved pathologies Alzheimer’s disease (AD). First, immunohistochemistry reveals frequent coexistence phosphorylated cortex AD patients. In vitro studies using primary mouse cortical neurons show that non-p-tau perinuclearly together tubulin after...
Neurogenesis occurs in restricted regions the adult mammalian brain, among which neurogenesis hippocampal dentate gyrus plays crucial role learning and memory. To date, little is known about neurogenic cues, result neuronal fate adoption of neural stem cells residing regions, especially cues neurogenesis. In present study, we show that astrocytes also granule adjacent to secrete a newly cloned novel secretory factor, Neurogenesin-1. This protein contains three cysteine-rich domains unique...
Whether preclinical depression is one of the pathophysiologic features Alzheimer disease (AD) has been under debate. In vivo molecular imaging helps clarify this kind issue. Here, we examined in changes brain serotoninergic system and glucose metabolism by scanning early- to moderate-stage AD patients with without using PET a radiotracer for serotonin transporter, <sup>11</sup>C-3-amino-4-(2-dimethylaminomethylphenylsulfanyl) benzonitrile (DASB), metabolic marker, <sup>18</sup>F-FDG....
Nicotinic acetylcholine receptor subtype α4β2 is considered important in the regulation of attention and memory, cholinergic degeneration known as one pathophysiology Alzheimer's disease. Brain amyloid-β protein deposition also a key pathological marker Recent imaging has shown many cognitively normal subjects with deposits, indicating missing link between cognitive decline. To date, relationship nicotinic burden not been elucidated vivo. In this study we investigated relation availability...
Neurons in the cerebral cortex and hippocampus discharge synchronously brain state-dependent manner to transfer information. Published studies have highlighted temporal coordination of neuronal activities between a neocortical area, however, how spatial extent activity relates hippocampal remains partially unknown. We imaged mesoscopic while recording local field potentials anesthetized unanesthetized GCaMP-expressing transgenic mice. found that elevates around sharp wave ripples (SWR)....
Abstract The glycine cleavage system (GCS) is the essential enzyme complex for degrading and supplying 5,10‐methylenetetrahydrofolate DNA synthesis. Inherited deficiency of this causes nonketotic hyperglycinemia, characterized by severe neurological symptoms frequent association brain malformations. Although high levels have been considered to cause above‐mentioned problems, detailed pathogenesis disease still unknown. Here we show that GCS abundantly expressed in rat embryonic neural...
Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects microglia-related neuroinflammatory responses in the brain. Relative increase TSPO expression that occurs slightly later during neuroinflammation a proinflammatory fashion, CB2 activation is relate neuroprotective predominantly at an early stage brain disorders. These findings, however, were deduced from studies with animal samples under...
Increased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) can be induced by stress growth factors in mammals, plays an important role cancer, diabetes, hypertension. A recent work suggested that SGK1 activity restores damage a stroke model. To further investigate the SGKs ischemic brain injury, we examined how SGK inhibitors influence outcome vivo neurotoxicity vitro. Infarct volumes were compared adult mice with middle cerebral artery occlusion, followed 24 h reperfusion,...
Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether irradiation rats caused behavioral abnormalities relevant to schizophrenia.A total dose of 15-Gy six fractionations during 3 weeks was exposed the forebrain including subventricular zone (SVZ) and subgranular (SGZ) with male prone position. Behavioral, immunohistochemical, neurochemical were performed three months after fractionated ionizing...
Brain β-amyloid (Aβ) deposition during normal aging is highlighted as an initial pathogenetic event in the development of Alzheimer's disease. Many recent brain imaging studies have focused on areas deactivated cognitive tasks [the default mode network (DMN), i.e., medial frontal gyrus/anterior cingulate cortex and precuneus/posterior cortex], where strength functional coordination was more or less affected by cerebral Aβ deposits. In present positron emission tomography study, to...
<h3>Background:</h3> In a genome-wide association study of autism, zinc finger protein 804A (<i>ZNF804A</i>) single nucleotide polymorphisms (SNPs) were found to be nominally associated in verbally deficient individuals with autism. Zinc copy number variations (CNVs) have also been observed addition, ZNF804A is known involved theory mind (ToM) tasks, and ToM deficits are deemed responsible for the communication social challenges faced by We hypothesized that <i>ZNF804A</i> could risk gene...
Abstract Cortical spreading depolarization (CSD) is a propagating wave of tissue characterized by large increase extracellular potassium concentration and prolonged subsequent electrical silencing neurons. Waves CSD arise spontaneously in various acute neurological settings, including migraine aura ischemic stroke. Recently, we have reported that pan-inhibition adrenergic receptors (AdRs) facilitates the normalization after photothrombotic stroke mice. Here, extended mechanistic study to ask...
The rat olfactory bulb is anatomically immature at birth, and considerable neurogenesis synaptogenesis are known to take place postnatally. In addition, significant physiological changes have also been reported in this period. For example, granule cell-mediated inhibition following electrical stimulations the lateral tract robust during first postnatal week, then decreases abruptly after second week. However, mechanism underlying enhanced remains be elucidated. To know cause of phenomenon,...
Background Obstetric complications have been regarded as a risk factor for schizophrenia later in life. One of the mechanisms underlying association is postulated to be hypoxic process brain offspring around time birth. Hippocampus one regions implicated late-onset dopaminergic dysfunction associated with obstetric complications. Methodology/Principal Findings We used an animal model perinatal asphyxia, which rat pups were exposed 15 min intrauterine anoxia during Cesarean section At 6 and...
Phosphatase and tensin homolog (PTEN) is a phosphoinositide phosphatase that regulates crucial cellular functions, including insulin signaling, lipid glucose metabolism, as well survival apoptosis. Silymarin the active ingredient in milk thistle exerts numerous effects through activation of PTEN. However, effect silymarin on development resistance remains unknown.Wistar rats fed fructose-rich chow or normal were administered oral to identify using homeostasis model assessment...