A5064366813- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Treatment of Major Depression
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- Drug Transport and Resistance Mechanisms
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Image and Signal Denoising Methods
- Radiomics and Machine Learning in Medical Imaging
- Alzheimer's disease research and treatments
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- S100 Proteins and Annexins
- Parathyroid Disorders and Treatments
Hamamatsu Photonics (Japan)
2013-2023
Hamamatsu Photonics (United Kingdom)
2014-2021
RIKEN Center for Brain Science
2001-2017
The University of Tokyo
2014
RIKEN
2006
Hamamatsu University
2006
Gifu University
2006
Nagoya University
2006
Osaka City University
2006
National Institute of Advanced Industrial Science and Technology
2004
R-ketamine appears to be a potent, long-lasting and safer antidepressant, relative esketamine (S-ketamine), since it might free of psychotomimetic side effects. Using [11C]raclopride positron emission tomography (PET), we investigated whether can affect dopamine D2/3 receptor binding in the conscious monkey brain. A single infusion (0.5 mg/kg), but not caused reduction availability striatum. This study suggests that unlike R-ketamine, cause release striatum, its associated with effects esketamine.
Abstract The risk of schizophrenia is increased in offspring whose mothers experience malnutrition during pregnancy. Polyunsaturated fatty acids (PUFAs) are dietary components that crucial for the structural and functional integrity neural cells, PUFA deficiency has been shown to be a factor schizophrenia. Here, we show gestational early postnatal deprivation two PUFAs—arachidonic acid (AA) docosahexaenoic (DHA)—elicited schizophrenia-like phenotypes mouse at adulthood. In PUFA-deprived...
Although convolutional neural networks (CNNs) demonstrate the superior performance in denoising positron emission tomography (PET) images, a supervised training of CNN requires pair large, high-quality PET image datasets. As an unsupervised learning method, deep prior (DIP) has recently been proposed; it can perform with only target image. In this study, we propose innovative procedure for DIP approach four-dimensional (4D) branch architecture end-to-end to denoise dynamic images. Our...
The effects of ketamine, a noncompetitive antagonist NMDA receptors, on the striatal dopaminergic system were evaluated multiparametrically in monkey brain using high-resolution positron emission tomography (PET) combination with microdialysis. L-[β-11C]DOPA, [11C]raclopride, and [11C]β-CFT used to evaluate dopamine synthesis rate, D2 receptor binding, transporter availability, respectively, conscious ketamine-anesthetized animals. Dopamine concentrations extracellular fluid (ECF)...
To evaluate the cholinergic and dopaminergic neuronal interaction in striatum, effects of scopolamine, a muscarinic antagonist, on striatal system were evaluated multi-parametrically conscious monkey brain using high-resolution positron emission tomography combination with microdialysis. l-3,4-Dihydroxyphenylalanine (l-[beta-(11)C]DOPA) 2beta-carbomethoxy-3beta-(4-fluorophenyl)tropane ([beta-(11)C]CFT) used to measure dopamine synthesis rate transporter (DAT) availability, respectively. For...
Background The α7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease. However, there are currently no suitable positron emission tomography (PET) radioligands for imaging nAChRs intact human brain. Here we report novel PET radioligand [11C]CHIBA-1001 vivo non-human primate Methodology/Principal Findings A receptor binding assay showed that CHIBA-1001 was a highly selective ligand...
The objective of this study was to investigate the relationship between normalized regional cerebral metabolic rates glucose (normalized-rCMRglc) and gait function in physically mentally high-functioning older women. One hundred eighty-two community-dwelling women (mean age [SD], 69.4 [6.6] years) without disability instrumental activities daily living mobility limitations underwent positron emission tomography with 18F-fluorodeoxyglucose at rest assess brain activity associated function. We...
To assess the capability of 18 F-2-tert-butyl-4-chloro-5-{6-[2-(2-fluoroethoxy)-ethoxy]-pyridin-3-ylmethoxy}-2H-pyridazin-3-one ( F-BCPP-EF), a novel positron emission tomography (PET) probe for mitochondrial complex I (MC-I) activity, as specific marker ischemia-induced neuronal death without being disturbed by inflammation, translational research was conducted using an animal PET in ischemic brains Cynomolgus monkeys Macaca fascicularis). Focal ischemia induced right middle cerebral artery...
<sup>18</sup>F-BCPP-EF was applied to assess mitochondrial complex I (MC-I) activity in the brains of Parkinson disease model monkeys prepared by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and also presynaptic dopamine parameters. <b>Methods:</b><sup>11</sup>C-β-CFT for transporter; <sup>11</sup>C-3,4-dihydroxy-phenyl-L-alanine (β-<sup>11</sup>C-L-DOPA), L-6-<sup>18</sup>F-fluorodopa (<sup>18</sup>F-FDOPA), or 6-<sup>11</sup>C-methyl-<i>m</i>-tyrosine (<sup>11</sup>C-6Me<i>m</i>Tyr)...
Abstract The effects of ketamine anesthesia on the binding [ 11 C]‐labeled cocaine analogs, C]β‐CFT (2β‐carbomethoxy‐3β‐(4‐fluorophenyl)tropane) and C]β‐CIT‐FE ( N ‐(2‐fluoroethyl)‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)tropane), to striatal dopamine transporter (DAT) were evaluated in monkey brain using positron emission tomography (PET). We sequentially measured kinetics these labeled compounds brains five young‐adult male rhesus monkeys Macaca mulatta ) conscious state, followed by those under...
Abstract This study demonstrated the effects of acute acetylcholinesterase (AChE) inhibition by donepezil (Aricept) on cerebral cholinergic neuronal system in brains young (5.2 ± 1.1 years old) and aged (20.3 2.6 monkeys ( Macaca mulatta ) conscious state. Donepezil at doses 50 250 μg/kg suppressed AChE activity, analyzed metabolic rate (k 3 N ‐[ 11 C]methyl‐4‐piperidyl acetate ([ C]MP4A), all cortical regions a dose‐dependent manner both age groups. However, suppression degree was more...
Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects microglia-related neuroinflammatory responses in the brain. Relative increase TSPO expression that occurs slightly later during neuroinflammation a proinflammatory fashion, CB2 activation is relate neuroprotective predominantly at an early stage brain disorders. These findings, however, were deduced from studies with animal samples under...
Microglial cells are activated in response to changes brain homeostasis during aging, dementia, and stroke. Type 2 endocannabinoid receptors (CB2) translocator protein 18 kD (TSPO) considered reflect distinct aspects of microglia-related neuroinflammatory responses the brain. CB2 activation is relate neuroprotective that may occur predominantly early stage disorders such as Alzheimer's disease, while an increase TSPO expression tends later neuroinflammation, a proinflammatory fashion....
<h3>BACKGROUND AND PURPOSE:</h3> Electrocardiographic gating, commonly used in MR carotid plaque imaging, can negatively affect intraplaque contrast if the TR is inappropriate. The present study aimed to determine whether a non-gated technique with appropriate TRs accurately evaluate characteristics specimens excised by CEA. <h3>MATERIALS METHODS:</h3> We prospectively examined 40 consecutive patients who underwent CEA (59–82 years of age) using 1.5T scanner. Axial T1WI 500 ms and PDWI T2WI...
In order to improve the denoising performance in positron emission tomography (PET) images, various smoothing filters have been applied. Recent reports on PET indicate that signal-to-noise and contrast-to-noise ratios improved by sinogram-based predenoising. this paper, we propose a dynamic image guided filtering (SDIGF) algorithm for noise reduction. The proposed uses normalized static sinogram as guidance image, acquiring entire data from start end of acquisition. evaluation, simulation...
Abstract A dopamine transporter (DAT) ligand 2β‐carbomethoxy‐3β‐(4‐fluoro‐phenyl)‐8‐(2‐[ 18 F]fluoroethyl)nortropane ([ F]β‐CFT‐FE) was synthesized and evaluated in comparison with [ 11 C]β‐CFT monkey brain using animal positron emission tomography (PET). F]β‐CFT‐FE were injected intravenously to conscious monkeys for a 91‐min PET scan arterial blood sampling metabolite analysis. In the state, provided peak about 20 min after injection declined thereafter striatum of brain, while...