A5035360381- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Imaging and Diagnostics
- Functional Brain Connectivity Studies
- Advanced X-ray and CT Imaging
- Glioma Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Atomic and Subatomic Physics Research
- Cancer, Hypoxia, and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone and Joint Diseases
- Intracranial Aneurysms: Treatment and Complications
- AI in cancer detection
- Vascular Malformations Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Asthma and respiratory diseases
Hokkaido University Hospital
2016-2025
Hokkaido University
2015-2025
Sapporo University
2023-2024
Korea National Institute of Health
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Tohoku University
1987-2023
Department of Medical Sciences
2023
Weatherford College
2021-2023
Central Institute for Experimental Animals
2023
Purpose To examine the variability in qualitative and quantitative results of computed tomographic (CT) perfusion imaging generated from identical source data stroke patients by using commercially available software programs provided various CT manufacturers. Materials Methods Institutional review board approval informed consent were obtained. 10 postprocessed five commercial packages, each which had a different algorithm: singular-value decomposition (SVD), maximum slope (MS), inverse...
Purpose To design a digital phantom data set for computed tomography (CT) perfusion and perfusion-weighted imaging on the basis of widely accepted tracer kinetic theory in which true values cerebral blood flow (CBF), volume (CBV), mean transit time (MTT), arrival delay are known to evaluate accuracy reliability postprocessing programs using this phantom. Materials Methods A was created by generating concentration-time curves reflecting CBF (2.5–87.5 mL/100 g per minute), CBV (1.0–5.0 g), MTT...
Objectives To determine the added discriminative value of detailed quantitative characterization background parenchymal enhancement in addition to tumor itself on dynamic contrast-enhanced (DCE) MRI at 3.0 Tesla identifying "triple-negative" breast cancers. Materials and Methods In this Institutional Review Board-approved retrospective study, DCE-MRI 84 women presenting 88 invasive carcinomas were evaluated by a radiologist analyzed using computer-aided techniques. Each its surrounding...
To develop and independently validate prognostic imaging biomarkers for predicting survival in patients with glioblastoma on the basis of multiregion quantitative image analysis.This retrospective study was approved by local institutional review board, informed consent waived. A total 79 from two independent cohorts were included. The discovery validation consisted 46 33 Cancer Imaging Archive (TCIA) institution, respectively. Preoperative T1-weighted contrast material-enhanced T2-weighted...
The purposes of this study are to establish oxygen extraction fraction (OEF) measurements using quantitative susceptibility mapping (QSM) magnetic resonance imaging (MRI), and compare QSM–OEF data with the gold standard 15 O positron emission tomography (PET). Twenty-six patients chronic unilateral internal carotid artery or middle cerebral stenosis occlusion, normal subjects were included. MRI scans conducted a 3.0 Tesla scanner three-dimensional spoiled gradient recalled sequence. QSM...
The "1-3-6-12-day rule" for starting direct oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation after acute ischemic stroke or transient attack recommends timings that may be later than used clinical practice. We investigated more practical optimal timing of DOAC initiation according to severity. combined data prospective registries Japan, Stroke Acute Management Urgent Risk-factor Assessment and Improvement-nonvalvular (September 2011 March 2014) RELAXED (February...
Importance Cell therapy is a promising treatment approach for stroke and other diseases. However, it unknown whether MultiStem (HLCM051), bone marrow–derived, allogeneic, multipotent adult progenitor cell product, has the potential to treat ischemic stroke. Objective To assess efficacy safety of when administered within 18 36 hours onset. Design, Setting, Participants The Treatment Evaluation Acute Stroke Using Regenerative Cells (TREASURE) multicenter, double-blind, parallel-group,...
Abstract Background The mismatch between diffusion weighted imaging (DWI) lesion and perfusion (PI) deficit volumes has been used as a surrogate of ischemic penumbra. This pathophysiology-orientated patient selection criterion for acute stroke treatment may have the potential to replace fixed time window. Two recent trials - DEFUSE EPITHET investigated concept in multicenter prospective approach. Both studies randomized highly selected patients (n = 74/n 100) therefore confirmation large...
Institutional review board approval and informed consent were obtained. The purpose was to evaluate the differences in tracer delay-induced effects of various deconvolution algorithms for computed tomographic (CT) perfusion imaging by using digital phantoms created from actual source data. Three methods singular value decomposition (SVD) evaluated. For standard SVD (sSVD), delays induced significant errors cerebral blood flow mean transit time. In contrast, block-circulant (bSVD), these...
Aim Neuronal degeneration in the locus coeruleus occurs early phase of A lzheimer's disease, similar to mild cognitive impairment. The produces norepinephrine, a deficiency which causes both memory disturbance and psychological symptoms. Thus, we evaluated signal alterations patients with disease impairment using high‐resolution fast spin‐echo T 1‐weighted imaging. Methods total 22 47 26 healthy controls were prospectively examined by imaging at 3 esla. Signal intensities manually measured...
A delay-insensitive probabilistic method for estimating hemodynamic parameters, delays, theoretical residue functions, and concentration time curves by computed tomography (CT) magnetic resonance (MR) perfusion weighted imaging is presented. Only a mild stationarity hypothesis made beyond the standard model. New microvascular parameters with simple interpretation are naturally introduced. Simulations on digital phantoms show that outperforms oscillating singular value decomposition (oSVD) in...
To assess the utility of histogram and texture analysis magnetic resonance (MR) fat-suppressed T2-weighted imaging (Fs-T2WI) for prediction histological diagnosis head neck squamous cell carcinoma (SCC) malignant lymphoma (ML). The cases 57 patients with SCC (45 well/moderately 12 poorly differentiated SCC) 10 ML were retrospectively analyzed. Quantitative parameters features (relative mean signal, coefficient variation, kurtosis skewness) gray-level co-occurrence matrix (GLCM) (contrast,...
BackgroundIschemic stroke is one of the leading causes death and neurological disability worldwide, stem cell therapy highly expected to reverse sequelae. This phase 1/2, first-in-human study evaluated safety, feasibility, monitoring an intracerebral-transplanted magnetic resonance imaging (MRI)-trackable autologous bone marrow stromal (HUNS001-01) for patients with subacute ischemic stroke.MethodsThe included adults severe due stroke. HUNS001-01 cultured human platelet lysates labeled...
Abstract Purpose To evaluate the efficacy of susceptibility weighted imaging (SWI) in comparison to standard T1 postgadolinium contrast (T1‐Gd) MRI patients with Sturge‐Weber Syndrome (SWS). Materials and Methods Twelve children (mean age, 5.6 years) diagnosis SWS unilateral hemispheric involvement were recruited prospectively examined high resolution three dimensional SWI conventional T1‐Gd. Both T1‐Gd images evaluated using a four‐grade scoring system according six types findings...
To detect diffusion abnormalities in the trigeminal nerves of patients with neuralgia (TN) caused by neurovascular compression (NVC) using a high-resolution tensor imaging (HR-DTI) technique.Thirteen TN and 14 healthy controls underwent HR-DTI scanning. After extracting nerve tractography technique, we measured fractional anisotropy (FA) apparent coefficient (ADC), compared contralateral ratios (CR) these parameters between controls, correlated cross-sectional areas nerves.The CRs FA values...