A5001586221- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Tracheal and airway disorders
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Radiomics and Machine Learning in Medical Imaging
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Venous Thromboembolism Diagnosis and Management
- Congenital Diaphragmatic Hernia Studies
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Pleural and Pulmonary Diseases
- MicroRNA in disease regulation
- Airway Management and Intubation Techniques
- Ultrasound in Clinical Applications
- Cytokine Signaling Pathways and Interactions
- Myasthenia Gravis and Thymoma
- Machine Learning in Materials Science
- Melanoma and MAPK Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Atrial Fibrillation Management and Outcomes
Hokkaido University Hospital
2017-2024
Toronto General Hospital
2020-2024
Hokkaido University
2013-2024
University Health Network
2020-2024
University of Toronto
2024
Kushiro City General Hospital
2015-2017
Sapporo Minami Hospital
2011-2013
Kanagawa Prefectural Hospital Organization
2011-2013
The University of Tokyo
2010-2013
Hiroshima University
2010-2013
Abstract Background This study examined the expression of CDC20 in human non‐small cell lung cancer (NSCLC), explored its clinicopathological significance, and evaluated as a potential prognostic marker. Methods A total 362 cases NSCLCs were analyzed immunohistochemically on tissue microarrays (TMAs). Additionally, immunoreactivity mitotic arrest defective protein 2 (MAD2) was also studied. The implications these molecules statistically. Results High‐level (CDC20‐H) detected 71 (19.6%)....
Dickkopf-1 (DKK1) is an inhibitor of Wnt/beta-catenin signaling that overexpressed in most lung and esophageal cancers. Here, we show its utility as a serum biomarker for wide range human cancers, offer evidence favoring the potential application anti-DKK1 antibodies cancer treatment. Using original ELISA system, high levels DKK1 protein were found serologic samples from 906 patients with cancers pancreas, stomach, liver, bile duct, breast, cervix, which also showed elevated expression DKK1....
BackgroundIschemic stroke is one of the leading causes death and neurological disability worldwide, stem cell therapy highly expected to reverse sequelae. This phase 1/2, first-in-human study evaluated safety, feasibility, monitoring an intracerebral-transplanted magnetic resonance imaging (MRI)-trackable autologous bone marrow stromal (HUNS001-01) for patients with subacute ischemic stroke.MethodsThe included adults severe due stroke. HUNS001-01 cultured human platelet lysates labeled...
Abstract Purpose: This study aims to discover novel biomarkers and therapeutic targets for lung cancers. Experimental Design: We screened genes showing elevated expression in the majority of cancers by genome-wide gene profile analysis 120 obtained cDNA microarray representing 27,648 or expressed sequence tags. In this process, we detected a encoding cleavage stimulation factor, 3′ pre-RNA, subunit 2, 64 kDa (CSTF2) as candidate. Immunohistochemical staining using tissue consisting 327 was...
Genome-wide gene expression profiling revealed that the Ras and EF-hand domain containing (RASEF) transcript was significantly transactivated in majority of lung cancers. Using cancer cells, transient RASEF promoted cell growth, whereas knockdown not only reduced its but resulted growth suppression cells. Immunohistochemical staining using tumor tissue microarrays consisting 341 archived non-small cancers (NSCLC) association strong positivity with poor prognosis (P = 0.0034 by multivariate...
Abstract While photodynamic therapy (PDT) can induce acute inflammation in the irradiated tumor site, a sustained systemic, adaptive immune response is desirable, as it may control growth of nonirradiated distant disease. Previously, we developed porphyrin lipoprotein (PLP), ∼20 nm nanoparticle photosensitizer, and observed that not only efficiently eradicated primary VX2 buccal carcinomas rabbits, but also induced regression metastases draining lymph node. We hypothesized PLP-mediated PDT...
Bronchopleural fistulas associated with empyema can occur as life-threatening sequelae after pulmonary resection, occurring most frequently pneumonectomy. Three bronchopleural fistulas, 5-6 mm in diameter, were successfully treated using a fibrin glue-coated collagen patch (FGCCP) and glue (FG) at the site of fistula. Through clinical experiences, we introduce methodology to perform endobronchial closure fistulas.Data collected by reviewing charts patients diagnosed post-lobectomy fistula...
Abstract Background The cutoff value of preoperative serum carcinoembryonic antigen (CEA) levels has not been investigated using appropriate subgroup analyses for non‐small cell lung carcinoma (NSCLC). This study was undertaken to determine whether the most predictive CEA level risk recurrence differs according histological type, and how smoking status influences values in Stage I NSCLC. Methods Subjects comprised NSCLC patients [141 with adenocarcinoma (ADC) 36 squamous (SCC)]. Results In...
A simple and safe surgical technique for nonpalpable lung tumors: One-stop Solution a tumor, Marking, Resection, Confirmation of the margin in Hybrid operating room (OS-MRCH)
Conventional flexible bronchoscopy has not achieved the high diagnostic yield for intrapulmonary lesions as seen with image-guided transthoracic biopsy. A thin convex probe endobronchial ultrasound bronchoscope (TCP-EBUS) a 5.9-mm tip was designed to improve peripheral access over conventional EBUS bronchoscopes facilitate real-time sampling of under guidance.TCP-EBUS inserted into distal airways ex-vivo human lungs assess bronchial accessibility relative clinically available bronchoscopes....
We report one of the rare anatomical variations pulmonary vein wherein left V2 drained into inferior vein. A 63-year-old man was referred to our hospital because an abnormal shadow in lower lung field that noted on chest X-ray. Computed tomography (CT) revealed a tumor lobe. biopsied specimen diagnosed as adenocarcinoma, and thus, lobectomy performed. Preoperative three-dimensional CT anomalous from superior segment This variation type confirmed during thoracoscopic lobectomy. were able...
Abstract Background Recurrence of cancer after curative surgery is a major problem most treatments. Increased sympathetic activity during the perioperative period could promote cell invasion to blood vessels and angiogenesis, resulting in metastasis. Recent studies showed that use beta blockers can be associated with prolonged survival patients cancer. The objective this study evaluate preventive effects landiolol hydrochloride, which an ultra-short-acting beta-1-selective blocker has been...
ObjectiveSevere pulmonary embolism is often managed with thrombolysis. We sought to determine whether endobronchial ultrasound (EBUS)-guided transbronchial thrombolysis remained effective at lower alteplase doses, the goal of minimizing potential bleeding risk.MethodsYorkshire pigs were anesthetized and ventilated. Preformed autologous blood clots administered into bilateral arteries via EBUS-guided injection. After documenting baseline clot sizes, was injected using a 25-gauge needle...
Endobronchial ultrasound-guided transbronchial needle injection (EBUS-TBNI) may effectively treat acute pulmonary embolisms (PEs). Here, we assessed the effectiveness of clot dissolution and safety tissue plasminogen activator (t-PA) using EBUS-TBNI in a 1-week survival study porcine PE model.Six pigs with bilateral PEs were used: 3 for t-PA (TBNI group) systemic administration (systemic group). Once created, each 25 mg (a total 50 t-PA) 100 was performed on day 1. Hemodynamic parameters,...
横隔膜ヘルニアの1型であるまれな傍裂孔ヘルニアの1例を経験したので報告する. 症例は70歳の女性で, 固形物摂取時の嚥下困難と嘔吐を主訴に, 当院を受診した. 上部消化管内視鏡検査とバリウム検査にて, 食道裂孔ヘルニアの傍食道型と術前診断した. 手術は腹腔鏡下に行い, 食道胃接合部および胃上部付近を剥離し, 後縦隔内に入り込んでいた胃穹隆部を整復したところ, ヘルニア門は左横隔膜にあり食道裂孔との間には横隔膜脚が介在していた. 横隔膜ヘルニア (傍裂孔ヘルニア) と判断し, ヘルニア門を閉鎖した後, 食道胃接合部付近剥離による逆流を考慮してToupet法を施行した. 術後経過は良好で, 11日目に退院した. 本症はまれな病態で, かつ術前診断が困難であることより術式の選択に迷うが, 本例ではヘルニア門の閉鎖とToupet法を施行し良好な結果を得ることができたことから, 本疾患に対し, 状況に応じてToupet法などを用いることは有用と考えられる.
This study aimed to determine the usefulness and limitations of videoassisted thoracoscopic (VATS) lobectomy using one-window puncture method (1WPM).This involved 14 patients who underwent 1WPM at our institute from 2008 2017.The comprised 3 men 11 women with a median age 10.5 years (range, 0-72 years). There were eight cases in children younger than 18 old youngest patient was 9 days old. The diagnoses congenital pulmonary cystic disease (n = 7), primary lung cancer 4), metastatic tumor 1),...