A5021867910- RNA modifications and cancer
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Melanoma and MAPK Pathways
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Systemic Sclerosis and Related Diseases
- Neuroscience of respiration and sleep
- Vasculitis and related conditions
- Plant Virus Research Studies
- Neuroendocrine Tumor Research Advances
- Sepsis Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Mycobacterium research and diagnosis
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Head and Neck Cancer Studies
- Computational Drug Discovery Methods
- COVID-19 and healthcare impacts
- Peripheral Neuropathies and Disorders
- Sarcoidosis and Beryllium Toxicity Research
The University of Tokyo
2011-2023
Hokkaido University
2013
Shiga University of Medical Science
2011-2013
Hiroshima University
2011-2013
Kanagawa Cancer Center
2011-2013
Saitama Cancer Center
2011-2013
Kanagawa Prefectural Hospital Organization
2011-2013
Chugoku Rosai Hospital
2009-2010
This study aims to identify novel biomarkers and therapeutic targets for lung cancer.We carried out gene expression profile analysis of 120 cancers screen genes encoding transmembrane/secretory molecules that are commonly transactivated in cancers. Epstein-Barr virus-induced 3 (EBI3), which encodes a secretory glycoprotein, was selected as good candidate. Immunohistochemical staining using tissue microarray consisting 414 non-small cell applied examine the level prognostic value EBI3. Serum...
Genome-wide gene expression profiling revealed that the Ras and EF-hand domain containing (RASEF) transcript was significantly transactivated in majority of lung cancers. Using cancer cells, transient RASEF promoted cell growth, whereas knockdown not only reduced its but resulted growth suppression cells. Immunohistochemical staining using tumor tissue microarrays consisting 341 archived non-small cancers (NSCLC) association strong positivity with poor prognosis (P = 0.0034 by multivariate...
Abstract Purpose: This study aims to identify molecules that might be useful as diagnostic/prognostic biomarkers and targets for the development of new molecular therapies lung cancer. Experimental Design: We screened genes were highly transactivated in a large proportion 120 cancers by means cDNA microarray representing 27,648 found chondrolectin (CHODL) candidate. Tumor tissue was applied examine expression CHODL protein its clinicopathologic significance archival non–small cell cancer...
The STOP-Bang test was used to detect patients at high risk of obstructive sleep apnea (OSA). We evaluated the usefulness for predicting severity OSA in Japanese patients.We retrospectively who performed full polysomnography Mihara Medical Association Hospital. correlation between score and hypopnea index (AHI) using Spearman's rank analysis. then multivariate analyses examine independent factor severe (AHI ≥ 30/hr).One hundred seven were diagnosed as no (n = 5), mild 17), moderate 30), 55)...
Accurate evaluation of disease status is very important in treatment Wegener's granulomatosis A 73-year-old Japanese man presented with chronic sinusitis and otitis media. He was admitted to our hospital because bilateral lung nodules. Cytoplasmic antineutrophil cytoplasmic antibody negative but his rheumatoid factor high. diagnosed limited received remission induction therapy. His serum level correlated the state when he experienced a severe infection recurrence due granulomatosis. We...
背景．近年，オシメルチニブ投与中にtransient asymptomatic pulmonary opacities（TAPOs）と呼ばれる予後良好の肺病変を高頻度に認めることが報告されている．症例．76歳の男性が肺腺癌に対してオシメルチニブを投与され，良好な治療経過を得ていた．36週目に無症候性の肺浸潤影が出現し，経気管支肺生検の病理学的検査では器質化肺炎に合致する所見であった．呼吸状態の悪化がみられず，患者が継続を強く希望したため，オシメルチニブを慎重に継続したところ，9週間後に浸潤影は消退した．結論．本症例はオシメルチニブ継続投与にも関わらず自然消退した経過からTAPOsが疑われた．TAPOsは重篤な薬剤性肺障害の初期段階との鑑別が難しく，肺癌診療における重要な臨床課題である．
目的：閉塞性睡眠時無呼吸症候群（obstructive sleep apnea syndrome：OSAS）のリスク評価における日本語版STOP-Bangテストの有用性を検証する．
背景．免疫チェックポイント阻害薬では一部の症例で長期奏効例がみられる．しかし，薬剤性肺障害などの免疫関連有害事象も遅発性に生じうる．症例．患者は71歳の男性．2年前から左下葉原発肺腺癌に対してペムブロリズマブを投与され，病変はほぼ消失した．胸部CTで左肺の上葉と下葉に新規陰影が出現し，気管支鏡にて左上葉病変から腺癌細胞を検出した．ペムブロリズマブ休薬後も浸潤影の拡大を認めたため，ステロイド薬を開始したところ，左上葉結節影を除いて浸潤影はほぼ消退した．肺癌再発と遅発性薬剤性肺障害を同時に生じたと考えられた．結論．画像所見だけでは肺癌再発と薬剤性肺障害の鑑別が難しいことがあり，気管支鏡検査による病理学的検討やステロイドへの反応性などを参考にして慎重に判断する必要がある．
To clarify the frequency of imaging findings similar to mycobacterial infection and characteristics comorbid pulmonary non-tuberculosis mycobacteriosis in patients with allergic bronchopulmonary mycosis (ABPM).Patients treated ABPM at our hospital past 8 years were extracted from medical records, 32 who met clinical diagnostic criteria retrospectively examined.The median age was 62.5 (range 24-79 years), 21 female. Twenty-two had asthma, four old tuberculosis. CT showed central...
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<div>Abstract<p><b>Purpose:</b> This study aims to identify molecules that might be useful as diagnostic/prognostic biomarkers and targets for the development of new molecular therapies lung cancer.</p><p><b>Experimental Design:</b> We screened genes were highly transactivated in a large proportion 120 cancers by means cDNA microarray representing 27,648 found chondrolectin (<i>CHODL</i>) candidate. Tumor tissue was applied examine...
<div>Abstract<p><b>Purpose:</b> This study aims to identify novel biomarkers and therapeutic targets for lung cancer.</p><p><b>Experimental Design:</b> We carried out gene expression profile analysis of 120 cancers screen genes encoding transmembrane/secretory molecules that are commonly transactivated in cancers. Epstein-Barr virus–induced 3 (<i>EBI3</i>), which encodes a secretory glycoprotein, was selected as good candidate....
<div>Abstract<p><b>Purpose:</b> This study aims to identify molecules that might be useful as diagnostic/prognostic biomarkers and targets for the development of new molecular therapies lung cancer.</p><p><b>Experimental Design:</b> We screened genes were highly transactivated in a large proportion 120 cancers by means cDNA microarray representing 27,648 found chondrolectin (<i>CHODL</i>) candidate. Tumor tissue was applied examine...
<div>Abstract<p><b>Purpose:</b> This study aims to identify novel biomarkers and therapeutic targets for lung cancer.</p><p><b>Experimental Design:</b> We carried out gene expression profile analysis of 120 cancers screen genes encoding transmembrane/secretory molecules that are commonly transactivated in cancers. Epstein-Barr virus–induced 3 (<i>EBI3</i>), which encodes a secretory glycoprotein, was selected as good candidate....
<p>PDF file - 52KB</p>
<p>PDF file - 143KB</p>