Hanne Christensen
A5026526616- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Muscle activation and electromyography studies
- Musculoskeletal pain and rehabilitation
- Ergonomics and Musculoskeletal Disorders
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Climate Change and Health Impacts
- Global Health Care Issues
- Cardiac Imaging and Diagnostics
- Social and Educational Sciences
- Education, Healthcare and Sociology Research
- Motor Control and Adaptation
- Health disparities and outcomes
- Global Public Health Policies and Epidemiology
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Advanced X-ray and CT Imaging
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
Copenhagen University Hospital
2016-2025
Bispebjerg Hospital
2016-2025
Palo Alto University
2025
University of Copenhagen
2015-2024
Frederiksberg Hospital
2001-2024
University of Nottingham
2008-2024
Institute for Health Metrics and Evaluation
2016-2024
Society of British Neurological Surgeons
2024
King's College London
2024
Population Health Research Institute
2021-2024
The burden of cardiovascular diseases (CVDs) remains unclear in many regions the world. GBD (Global Burden Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for burden. CVD was estimated from vital registration verbal autopsy data. prevalence using modeling software health surveys, prospective cohorts, system administrative data, registries. Years lived with disability (YLD) were by multiplying weights. life lost...
Stroke is a leading cause of mortality and disability worldwide the economic costs treatment post-stroke care are substantial. The Global Burden Diseases, Injuries, Risk Factors Study (GBD) provides systematic, comparable method quantifying health loss by disease, age, sex, year, location to provide information systems policy makers on more than 300 causes disease injury, including stroke. results presented here estimates burden due overall stroke ischaemic haemorrhagic from GBD 2016.
Comparable data on the global and country-specific burden of neurological disorders their trends are crucial for health-care planning resource allocation. The Global Burden Diseases, Injuries, Risk Factors (GBD) Study provides such information but does not routinely aggregate results that interest to clinicians specialising in conditions. In this systematic analysis, we quantified disease due 2015 its relationship with country development level.We estimated prevalence, mortality,...
The time to initiate intravenous thrombolysis for acute ischemic stroke is generally limited within 4.5 hours after the onset of symptoms. Some trials have suggested that treatment window may be extended in patients who are shown but not yet infarcted brain tissue on imaging.
Intracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view recent randomized controlled trials (RCTs) management ICH, European Stroke Organisation (ESO) has updated its evidence-based guidelines ICH.A multidisciplinary writing committee 24 researchers from 11 countries identified 20 questions relating ICH created recommendations based on evidence RCTs using Grading Recommendations...
BackgroundTranexamic acid can prevent death due to bleeding after trauma and post-partum haemorrhage. We aimed assess whether tranexamic reduces haematoma expansion improves outcome in adults with stroke intracerebral haemorrhage.MethodsWe did an international, randomised placebo-controlled trial haemorrhage from acute units at 124 hospital sites 12 countries. Participants were randomly assigned (1:1) receive 1 g intravenous bolus followed by 8 h infusion of or a matching placebo, within...
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Following stroke, acute symptomatic seizures (manifestation within seven days) and epilepsy, i.e. occurrence of at least one unprovoked seizure after more than days), are reported in 3-6% up to 12% patients, respectively. Incidence is higher intracranial haemorrhage (10-16%) ischaemic stroke (2-4%). Acute may be associated with unfavourable functional outcome increased mortality. In view the clinical relevance, European Stroke Organisation has issued evidence-based guidelines on management...
The purpose of the European Stroke Organisation–Karolinska Update Conference is to provide updates on recent stroke therapy research and give an opportunity for participants discuss how these results may be implemented into clinical routine. meeting started 22 years ago as Karolinska Update, but since 2014 it a joint conference with Organisation. Importantly, provides platform discussion Organisation guidelines process recommendations committee specific topics. By this, adds direct influence...
The optimal blood pressure (BP) management in acute ischaemic stroke (AIS) and intracerebral haemorrhage (ICH) remains controversial. These European Stroke Organisation (ESO) guidelines provide evidence-based recommendations to assist physicians their clinical decisions regarding BP stroke. were developed according the ESO standard operating procedure Grading of Recommendations, Assessment, Development, Evaluation (GRADE) methodology. working group identified relevant questions, performed...
Improving stroke services is critical for reducing the global burden. The World Stroke Organization-World Health Organization-Lancet Neurology Commission on conducted a survey of status in low and middle-income countries (LMICs) compared to high-income countries.Using validated Organization comprehensive questionnaire, we collected data along four pillars quadrangle (surveillance, prevention, acute stroke, rehabilitation) 84 across regions economic strata. also non-communicable diseases 194...
BackgroundPatients with acute intracerebral hemorrhage who are receiving factor Xa inhibitors have a risk of hematoma expansion. The effect andexanet alfa, an agent that reverses the effects inhibitors, on volume expansion has not been well studied.MethodsWe randomly assigned, in 1:1 ratio, patients had taken within 15 hours before having to receive or usual care. primary end point was hemostatic efficacy, defined by 35% less at 12 after baseline, increase score National Institutes Health...
It has been suggested that lesions in the insula may result abnormal electrocardiographic (ECG) findings and increase risk of sudden death. We investigated if computed tomography (CT) detected insular due to acute stroke were related ECG abnormalities mortality at three months. Acute diagnosed 43/179 patients (left = 25; right 17; bilateral 1) with (cerebral infarcts 62 intracerebral haemorrhage 17) based on CT scans from 5–8 days after onset; 12 lead ECGs recorded admission telemetry was...
BackgroundIntensive antiplatelet therapy with three agents might be more effective than guideline treatment for preventing recurrent events in patients acute cerebral ischaemia. We aimed to compare the safety and efficacy of intensive (combined aspirin, clopidogrel, dipyridamole) that guideline-based therapy.MethodsWe did an international, prospective, randomised, open-label, blinded-endpoint trial adult participants ischaemic stroke or transient attack (TIA) within 48 h onset. Participants...