A5065850779- Acute Ischemic Stroke Management
- Bone health and osteoporosis research
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Bone Metabolism and Diseases
- Venous Thromboembolism Diagnosis and Management
- Hormonal and reproductive studies
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Vitamin D Research Studies
- Muscle metabolism and nutrition
- Neurological Disease Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Bone health and treatments
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Enhanced Recovery After Surgery
- Blood properties and coagulation
- Thermal Regulation in Medicine
- Pharmacology and Obesity Treatment
- Ophthalmology and Visual Impairment Studies
- Blood Coagulation and Thrombosis Mechanisms
- Advanced MRI Techniques and Applications
- Cystic Fibrosis Research Advances
Herlev Hospital
2012-2024
Copenhagen University Hospital
1990-2021
University of Copenhagen
1988-2019
Gentofte Hospital
2006-2019
Bispebjerg Hospital
1999-2014
Aase og Ejnar Danielsens Fond
2013
Lundbeck Foundation
2013
Capital Region of Denmark
2011
University of Groningen
2010
Heidelberg University
2010
Intracerebral hemorrhage (ICH) accounted for 9% to 27% of all strokes worldwide in the last decade, with high early case fatality and poor functional outcome. In view recent randomized controlled trials (RCTs) management ICH, European Stroke Organisation (ESO) has updated its evidence-based guidelines ICH.A multidisciplinary writing committee 24 researchers from 11 countries identified 20 questions relating ICH created recommendations based on evidence RCTs using Grading Recommendations...
OBJECTIVE--To examine the role of peak bone mass and subsequent postmenopausal loss in development osteoporosis reliability identifying women at risk from one measurement biochemical assessment future loss. DESIGN--Population based study. SETTING--Outpatient clinic for research into osteoporosis. SUBJECTS--178 healthy early who had participated a two year study 1977. 154 underwent follow up examination 1989, whom 33 were excluded because diseases or taking drugs known to affect calcium...
To study the dose related response of salmon calcitonin (salcatonin) given intranasally on bone mass and turnover effect salcatonin rates fracture in elderly women with moderate osteoporosis.Double blind, placebo controlled, randomised group comparison.Outpatient clinic for research into osteoporosis.208 healthy aged 68-72 years who had a mineral content distal forearm average 30% below mean value premenopausal women.The 208 were allocated randomly blocks four to two treatment either 50 IU,...
OBJECTIVE--To study the effect of salmon calcitonin (salcatonin) given intranasally on calcium and bone metabolism in early postmenopausal women. DESIGN--Double blind, placebo controlled, randomised group comparison. SETTING--Outpatient clinic for research into osteoporosis. SUBJECTS--52 Healthy women who had a natural menopause two half to five years previously. INTERVENTIONS--The 52 were allocated randomly treatment with either salcatonin 100IU (n = 26) or 26). Both groups received...
SUMMARY Thirty‐seven women with established osteoporosis completed a one‐year double‐blind, placebo‐controlled study the primary aim of examining effect nasal salmon calcitonin (200 IU daily) on bone and calcium metabolism. All received daily supplement 500 mg. For comparison we also report data from an age‐matched group healthy who did not receive supplementation. The mineral measured in forearm (single photon absorptiometry) spine (dual showed similar pattern during treatment. ( n = 17)...
Objectives: Dysphagia occurs in approximately 51%–78% of patients with acute stroke. The incidence pneumonia caused by aspiration dysphagic increases both mortality and the need for hospitalization. aim this study was to investigate whether could be reduced such an early screening dysphagia intensified oral hygiene. Material Methods: In controlled trial, 146 hospitalized stroke moderate or severe were included three groups: intervention group (n = 58), one internal control 58,...
Objective: To evaluate if home-based rehabilitation of inpatients improved outcome compared to standard care. Design: Interventional, randomised, safety/efficacy open-label trial. Setting: University hospital stroke unit in collaboration with three municipalities. Subjects: Seventy-one eligible patients (41 women) focal neurological deficits hospitalised a for more than days and need rehabilitation. Interventions: Thirty-eight were randomised during hospitalization up four weeks after...
Antiplatelets (APs) may increase the risk of symptomatic intracerebral hemorrhage (ICH) following intravenous thrombolysis after ischemic stroke.We assessed safety under APs in 11,865 patients compliant with European license criteria and recorded between 2002 2007 Safe Implementation Treatments Stroke (SITS) International Thrombolysis Register (SITS-ISTR). Outcome measures univariable multivariable analyses included ICH (SICH) per SITS Monitoring Study (SITS-MOST [deterioration National...
The purpose of this study was the development a model embolic stroke with high reproducibility concerning infarct volume. In 37 male Sprague–Dawley rats, internal carotid artery embolized in vitro preformed suspensions autologous microemboli resembling arterial thrombi. With method continuous flow through catheter, reflux blood uncontrolled clotting and embolization avoided, thereby providing control animals free ischemic damage. had occlusions on angiograms immediately after no spontaneous...
We sought to evaluate the effects of combination cytidine-5'-diphosphocholine (citicoline) and thrombolysis on infarct size, clinical outcome, mortality in a rat embolic stroke model.Eighty-three Sprague-Dawley rats were embolized carotid territory with single fibrin embolus randomly assigned following treatment groups: (1) control (saline), (2) citicoline 250 mg/kg, (3) 500 (4) recombinant tissue plasminogen activator (rtPA) 5 (5) rtPA mg/kg plus (6) mg/kg. was administered as continuous...
Abstract Background Due to increasing older populations worldwide, injuries, disabilities and deaths caused by falls among the elderly represent a growing human societal problem. We aimed improve health men of at least 70 years age with low‐normal low testosterone mobility problems using undecanoate (TU) injections, progressive strength training, oral supplements vitamin D, calcium protein. Methods This was single‐centre, randomized, placebo‐controlled, double‐blind trial 148 median 77...
We examined the spontaneous bone loss in two populations of healthy postmenopausal women, who were followed for 9.5 and 14.5 years without any treatment influencing calcium metabolism. The mass was measured different skeletal areas: distal forearm, lumbar spine, proximal femur, total skeleton. skeleton fitted to an exponential model as a function since menopause. overall averaged 20-25% premenopausal 16 after patterns were, however, axial peripheral Thus, forearm approached more linear with...
Objectives– To evaluate how soon after stroke the diagnosis of hypertension could be established. Methods– In a prospective study including 1192 patients with acute within 6 h, blood pressure was measured serially at 2-h intervals during first 24 h. Results are presented as mean arterial (MAP). The Scandinavian Stroke Scale (SSS) assessed neurological deficit. Results– 779 mild to moderate ischaemic or transient attack (TIA) and SSS > 25, MAP 118 mmHg (CI 95%: 116–119 mmHg) on admission 109...
Background and Purpose— Poststroke fatigue is common reduces quality of life. Current evidence for intervention limited, this the first placebo-controlled trial to investigate treatment poststroke with wakefulness promoting drug modafinil. Methods— The was randomized, double-blinded, placebo-controlled. Patients were treated 400-mg modafinil or placebo 90 days. Assessments done at inclusion, 30, 90, 180 primary end point days measured by Multidimensional Fatigue Inventory-20 general domain....
Thrombolytic therapy with recombinant tissue plasminogen activator was tested in a rat embolic stroke model. The carotid territory embolized arterial-like microthrombi formed under pressure. Hemispheric cerebral blood flow before and after embolization measured by the intraarterial Xenon-133 injection method. Fifteen minutes embolization, 24 rats were treated 3 mg/kg or 10 activator, 27 saline. Carotid angiography displayed rate of occlusion arterial supply treatment. Brains fixed evaluated...
The effect of delayed thrombolysis with recombinant tissue plasminogen activator was tested in an embolic stroke model. carotid territory embolized 103 rats fibrin-rich clots formed and washed polyethylene tubes. Hemispheric cerebral blood flow before after embolization measured by the intra arterial 133 Xe injection method. At five delay times, 15–240 min embolization, 69 animals were treated activator, 20 mg/kg, 34 saline. Carotid angiography displayed grade occlusion supply treatment....