A5063127713- Multiple Sclerosis Research Studies
- Blood Pressure and Hypertension Studies
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cytokine Signaling Pathways and Interactions
- Neurological Disorders and Treatments
- Cerebrovascular and genetic disorders
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrhythmias and Treatments
- Amyotrophic Lateral Sclerosis Research
- Musculoskeletal pain and rehabilitation
- Fungal Plant Pathogen Control
- Rheumatoid Arthritis Research and Therapies
- Intracerebral and Subarachnoid Hemorrhage Research
- Hemodynamic Monitoring and Therapy
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Olfactory and Sensory Function Studies
- Phosphodiesterase function and regulation
- Mycobacterium research and diagnosis
- Atrial Fibrillation Management and Outcomes
- Cerebral Palsy and Movement Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- ECG Monitoring and Analysis
- Cardiovascular and Diving-Related Complications
Zealand University Hospital
2024-2025
Copenhagen University Hospital
2015-2025
Herlev Hospital
2015-2024
Nordsjællands Hospital
2023-2024
Glostrup Hospital
2024
Rigshospitalet
2020-2024
Hvidovre Hospital
2024
Gentofte Hospital
2019-2024
Weatherford College
2024
Bispebjerg Hospital
2024
Objective: To evaluate if home-based rehabilitation of inpatients improved outcome compared to standard care. Design: Interventional, randomised, safety/efficacy open-label trial. Setting: University hospital stroke unit in collaboration with three municipalities. Subjects: Seventy-one eligible patients (41 women) focal neurological deficits hospitalised a for more than days and need rehabilitation. Interventions: Thirty-eight were randomised during hospitalization up four weeks after...
Background: In multiple sclerosis (MS), the educational gradient in diagnostic and disease-modifying treatment (DMT) delays is sparsely examined, results are mixed. Objectives: Among patients with relapsing-remitting MS (RRMS), we aimed to examine delay initiation of first DMT. Design: A nationwide cohort study. Methods: We linked Danish Multiple Sclerosis Registry other registries. Diagnostic was evaluated 4344 ⩾20 years at clinical onset from January 1, 2012, onwards, diagnosed by March...
Background and Purpose— Poststroke fatigue is common reduces quality of life. Current evidence for intervention limited, this the first placebo-controlled trial to investigate treatment poststroke with wakefulness promoting drug modafinil. Methods— The was randomized, double-blinded, placebo-controlled. Patients were treated 400-mg modafinil or placebo 90 days. Assessments done at inclusion, 30, 90, 180 primary end point days measured by Multidimensional Fatigue Inventory-20 general domain....
Aims Prolonged cardiac monitoring after stroke is recommended though there no consensus on optimal methods. Short-term ECG recordings with a “thumb-ECG” device have shown promising preliminary results regarding effectiveness and cost benefit. We aimed to examine the performance of thumb-ECG five days’ Holter in prospective trial. A secondary endpoint was inter-observer agreement thumb-ECG. Methods Patients older than 65 years history atrial fibrillation who suffered an acute or transient...
Background Fatigue is a common and often debilitating stroke sequela, it important to accurately define detect post-stroke fatigue. Often questionnaires are used but case definition has been developed proposed as better tool.Objectives The aim of the study was determine validity inter-rater agreement fatigue, optimal cutoff scores for marked fatigue on Multidimensional Inventory-20 Severity Scale-7 questionnaires.Methods Stroke patients were interviewed with structured interview schedule...
Background Clinicians frequently rely on relapse counts, T2 MRI lesion load (T2L) and Expanded Disability Status Scale (EDSS) scores to guide treatment decisions for individuals diagnosed with multiple sclerosis (MS). This study evaluates how these factors, along age sex, influence prognosis during teriflunomide (TFL). Methods We conducted a nationwide cohort using data from the Danish Multiple Sclerosis Registry. Eligible participants had relapsing-remitting MS or clinically isolated...
To investigate the prognostic effect of relapse count, T2 MRI lesion load (T2L), Expanded Disability Status Scale (EDSS) scores, age, and sex in patients newly diagnosed with multiple sclerosis (MS) commencing teriflunomide (TFL) treatment.
<title>Abstract</title> <bold>Background</bold>: Targeted treatment is highly warranted for cerebral small vessel disease, a causal factor of one in four strokes and major contributor to vascular dementia. Patients with disease have impaired blood flow reactivity. Tadalafil specific phosphodiesterase 5 inhibitor shown improve reactivity the brain. <bold>Methods</bold>: The ETLAS-2 trial phase 2 double-blind, randomized placebo-controlled, parallel feasibility tadalafil as primary outcome....
Targeted treatment is highly warranted for cerebral small vessel disease, a causal factor of one in four strokes and major contributor to vascular dementia. Patients with disease have impaired blood flow reactivity. Tadalafil specific phosphodiesterase 5 inhibitor shown improve reactivity the brain.
Abstract Currently, there are limited therapeutic options for patients with non-active secondary progressive multiple sclerosis. Therefore, real-world studies have investigated differences between relapsing-remitting sclerosis, sclerosis and active Here, we explore patterns predictors of transitioning these phenotypes. We performed a cohort study using data from The Danish Multiple Sclerosis Registry. included phenotype, registered changes to subsequent transitions relapsing non-relapsing...
Background: Teriflunomide has been associated with an increased risk of hypertension. Real-world studies including adequate control groups are lacking. We hypothesized that patients multiple sclerosis (MS) treated teriflunomide would be at higher developing hypertension than those dimethyl fumarate. Methods: conducted a cohort study linking the Danish Multiple Sclerosis Registry national health registries during 10-year period. ( N = 2656) and fumarate 2237) exposure was defined by first...
Abstract Objectives In Denmark, 25% of hospital admissions with stroke are recurrent strokes. With thrombolytic treatment, more patients survive only minor disability. This promising development should be followed up by intensive secondary prevention. Hypertension is the most important target. We aimed at testing hypotheses that early follow‐up in a preventive clinic would result (a) higher proportion blood pressure target and (b) time to recurrence, myocardial infarction, death longer...
Background Treatment switching is a common challenge and opportunity in real-world clinical practice. Increasing diversity disease-modifying treatments (DMTs) has generated interest the identification of reliable robust predictors treatment across different countries, DMTs, time periods. Objective The objective this retrospective, observational study was to identify independent population relapsing-remitting MS (RRMS) patients Big Multiple Sclerosis Data Network national registries,...
Objective Transoesophageal echocardiography (TEE) is the gold standard for detection of cardiac emboli sources in ischaemic stroke patients, but new computed tomography (CT) scanners are able to visualize heart. This pilot study aimed compare findings on TEE with combined cardiovascular scan and cerebral CT angiography cryptogenic patients. Methods enrolled patients who underwent a examination, which were interpreted blinded manner. Results Twelve included (mean age 56 years). Of these, 10...