Extracellular matrix (ECM)-contained grafts can be achieved by decellularization of native bones or synthetic scaffolds. Limitations associated with harvesting the bone has raised interest in preparing vitro ECM bioscaffold for tissue engineering. Here, we intend to develop an ECM-contained construct via decellularizing engineered gelatin-coated β-tricalcium phosphate (gTCP) scaffold. In order find optimal protocol cell-loaded gTCP scaffolds, they were seeded buccal fat pad-derived stem...

Acetylation and trimethylation of histone H3 lysine 27 (H3K27ac H3K27me3) generally activate repress transcription, respectively. Concurrent activation H3K27ac H3K27me3 has been reported to correlate with poor prognosis in hepatocellular carcinoma. A high level shown be associated advanced oral squamous cell carcinoma (OSCC) tumour stage, but prognostic impact alone/or combination OSCC patients had not yet reported.In this study, immunohistochemistry using specific antibodies against was...

Oral cavity is not a usual site for metastasis, accounting about 1% of all oral tumors. The majority metastasis the mandible and less common maxilla followed by intraoral soft tissue. These tumors may be first clinical manifestation primary lesion. One most important sites neoplasm that metastasizes to jaws kidney. Therefore, considering this fact metastatic always are seen in typical site, it necessary rule out carcinomas jaws. We presented two cases renal cell carcinoma with different...

Abstract Background Large-scale genetic and epigenetic deregulations enable cancer cells to ectopically activate tissue-specific expression programmes. A specifically designed strategy was applied oral squamous cell carcinomas (OSCC) in order detect ectopic gene activations develop a prognostic stratification test. Methods dedicated original prognosis biomarker discovery approach implemented using genome-wide transcriptomic data of OSCC, including training validation cohorts. Abnormal...

Ameloblastoma is a common locally invasive but slow-growing neoplasm of the jaws with an odontogenic origin. Association between BRAF V600E mutation and clinicopathologic features behavior ameloblastoma remains controversial. This study aimed to evaluate gene expression its related proteins parameters in conventional ameloblastoma.50 Formalin-fixed paraffin-embedded blocks were included this study. Immunohistochemistry was done using rabbit monoclonal mutation-specific antibody VE1....

The microRNAs are molecules which have important biologic role and play key point in cancers. aim of present study was to determine the miR-21, miR-24, miR-29a expression serum patients with oral squamous cell carcinoma.Blood samples were obtained from 40 (20 cases 20 control group) expressions by using real-time PCR ΔCT.Mean -2.28 ± 2.15 5.61 2.38 case groups, respectively. miR-21 6.90 3.86 -0.88 2.31 According results, miR-24 2.13 2.89 -0.35 2.44 control, A significant difference observed...

Desmoplastic fibroma (DF) is a benign, locally aggressive neoplasm that rarely occurs in the facial skeleton.It usually presents during first three decades of life.Due to its aggressiveness and high recurrence rate, early diagnosis imperative, complete surgical removal lesion treatment choice.Herein, we present cases DF namely 2 year-old girl with mandibular DF, 9 boy maxillary 1.5-year old DF.Complete clinicopathological information, plan long-term follow-up patients are...

High-risk Human Papillomavirus (HPV) genotypes are found in malignant oral epithelial lesions, and HPV infection is proposed as a risk factor for initiating Squamous cell carcinoma (SCC) the head neck region. This study suggests practical approach to detect HPV-associated dysplasia (HAOED).

Chondrosarcomas are a group of malignant neoplasms with cartilaginous matrix production mostly found in flat and peripheral long bones. Mesenchymal chondrosarcoma is one the most unusual rare histological variants chondrosarcoma, distinct histopathological appearance biologically aggressive behavior. The amount cartilage mesenchymal may be so abundant that it easily random sections or scarce numerous required to discover it. In such cases, tough make an accurate diagnosis, which leads big...

The important role of the human papillomavirus (HPV) is widely established in oropharyngeal squamous cell carcinoma (OPSCC). behavior a OPSCCs especially induced by HPV might be influenced tissue microenvironment and its changes according to tumor nature. Recognition on neoplastic cells has led utilization use as therapeutic target. Carcinoma-associated fibroblasts (CAFs), most abundant microenvironment, show wide-spread expression alpha-smooth muscle actin (α-SMA). We focused CAFs, presence...

Abstract Osteosarcoma of the jaw can be successfully treated by a single aggressive surgical operation with good prognosis. Timely diagnosis, complete removal tumor clear margins, fulfill favorable clinical results.

Orthokeratinized odontogenic cyst (OOC) is an uncommon cyst. It has been categorized as a subtype of keratocyst (OKC). In 2005, it was classified distinct entity. OOC should be histopathologically differentiated from OKC, which higher recurrence rate and lower malignant potential. addition, examined for transformation. The epithelium cysts may rarely show However, transformation reported in inflammatory such the residual periapical number carcinomas arising low. This paper describes eight...

Background: Squamous cell carcinoma antigen (SCCA) is used as a prognostic marker for recurrence of squamous in various sites, including head and neck. Studies suggest that its high serum levels are correlated to some clinical features, such nodal metastasis. However, it still unknown if SCCA patients with tissue expression tumor cells related peripheral T-lymphocytes. Therefore, we did this study evaluate verrucous compare normal oral mucosa, also investigating the correlation between...

Background: Altered acetyl CoA acetyltransferase 1 (ACAT1) expression has been reported in diverse cancers. However, the of ACAT1 and its prognostic value oral squamous cell carcinoma (OSCC) remained unexplored. Materials methods: In this study, was analysed by immunohistochemistry (IHC) 61 OSCC patients compared between adjacent pre-tumour tissue 21 patients. Results: The tumours is heterogeneous More specifically, 52.38% show low both tumour tissues, 9.52% high pre-tumour, 19.05% have...

Abstract Oral focal mucinosis (OFM) is an extremely rare benign lesion of the oral cavity with unknown etiology, considered counterpart cutaneous mucinosis. It occurs mainly in women fourth and fifth decades life. has no characteristic features, diagnosis depends on histological evaluation. Its pathogenesis related to excessive production hyaluronic acid by fibroblasts during collagen production, which leads myxoid degeneration. To date, ten documented cases have been reported literature...

Salivary duct carcinoma (SDC) is a rare and highly aggressive salivary gland tumor with poor prognosis, rapid growth, distant metastasis, early regional high rate of recurrence.The parotid the most common site involvement, lungs bones are sites metastasis SDC.Herein, we present case SDC in 62-year-old male patient an unusual to skin primary brain 6 years after treatment, which comprised total parotidectomy radical neck dissection followed by radiotherapy.It noteworthy that few cases...

Rhabdomyosarcoma is a malignant skeletal muscle neoplasm. The tumor much more common in children, and the most frequent site head neck region. Since this less than other neoplasms oral cavity, clinicians sometimes ignore it, working patients up. high-grade malignancy with poor prognosis. Considering aggressive behavior various clinical or histopathologic presentations of tumor, early diagnosis has significant impact on treatment outcome prognosis patients. We highlight importance combining...

Abstract Background Oral squamous cell carcinoma (OSCC) is the most common cancer affecting oral and maxillofacial region. This study aimed to investigate role of stem cells (CSCs) in angiogenesis hypoxic response OSCC. Methods retrospective observational evaluated 56 cases OSCC using dual immunohistochemistry. Octamer-binding transcription factor 3/4 (OCT3/4) marker was used evaluate CSC activity. Glucose transporter 1 (GLUT1) angiogenesis, while endoglin (CD105) late stage blood vessel...

Abstract In the oral cavity, adenoid cystic carcinomas of buccal mucosa are extremely rare. Minor salivary grand carcinoma should receive aggressive treatment to achieve negative surgical margins inhibit recurrence.