A5037028657- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Advanced Polymer Synthesis and Characterization
- Asthma and respiratory diseases
- 3D Printing in Biomedical Research
- Pharmacological Effects and Assays
- Pluripotent Stem Cells Research
- Advanced Cellulose Research Studies
- Periodontal Regeneration and Treatments
- biodegradable polymer synthesis and properties
- Nasal Surgery and Airway Studies
- SARS-CoV-2 and COVID-19 Research
- Neuroscience and Neural Engineering
- Photopolymerization techniques and applications
- Pancreatic function and diabetes
- Nanoparticle-Based Drug Delivery
- CRISPR and Genetic Engineering
- Tendon Structure and Treatment
- Graphene and Nanomaterials Applications
- Silk-based biomaterials and applications
- Nanocomposite Films for Food Packaging
- CAR-T cell therapy research
Marquette University
2019-2022
Shahid Beheshti University of Medical Sciences
2016-2018
National Institute of Genetic Engineering and Biotechnology
2014-2017
In the embryonic heart, electrical impulses propagate in a unidirectional manner from sinus venosus and appear to be involved cardiogenesis. this work, aligned random polyaniline/polyetersulfone (PANI/PES) nanofibrous scaffolds doped by Camphor-10-sulfonic acid (β) (CPSA) were fabricated via electrospinning used conduct multidirectional fashion, respectively. A bioreactor was subsequently engineered apply cells cultured on PANI/PES scaffolds. We established cardiovascular disease-specific...
The ability of mesenchymal stem cells (MSCs) to enhance cutaneous wound healing has been well established. Extensive expansion reach sufficient cell numbers for regenerating tissues always limited cell-based therapies. An ingenious solution address this challenge is develop a strategy increase the immunomodulatory effects MSCs without expanding them. In study, we employed simple characteristic cells. It was observed that an optimized three-dimensional (3D) MSC culture in spheroid forms...
ABSTRACT Nasal septal cartilage perforations occur due to the different pathologies. Limited healing ability of results in remaining defects and further complications. This study sought assess efficacy elastin–gelatin–hyaluronic acid (EGH) scaffolds for regeneration nasal rabbits. Defects (4 × 7 mm) were created 24 New Zealand They randomly divided into four groups: Group 1 was control group with no intervention, 2 received EGH implanted defects, 3 seeded autologous auricular chondrocytes 4...
Human-induced pluripotent stem cells (hiPSCs) can potentially serve as an invaluable source for cell replacement therapy and allow the creation of patient- disease-specific without controversial use embryos avoids any immunological incompatibility. The generation insulin-producing pancreatic β-cells from in vitro provides unprecedented personal drug discovery transplantation diabetes. A new five-step protocol was introduced this study, effectively induced hiPSCs to differentiate into...
Abstract Dynamic‐based systems are bio‐designed in order to mimic the micro‐environments of bone tissue. There is limited direct comparison between perfusion and perfusion‐rotation forces designing a bioreactor. Hence, current study, we aimed compare given bioreactors for regeneration. Two types including rotating & were designed. Mesenchymal stem cells derived from buccal fat pad loaded on gelatin/β‐Tricalcium phosphate scaffold. Cell‐scaffold constructs subjected different treatment...
Extracellular matrix (ECM)-contained grafts can be achieved by decellularization of native bones or synthetic scaffolds. Limitations associated with harvesting the bone has raised interest in preparing vitro ECM bioscaffold for tissue engineering. Here, we intend to develop an ECM-contained construct via decellularizing engineered gelatin-coated β-tricalcium phosphate (gTCP) scaffold. In order find optimal protocol cell-loaded gTCP scaffolds, they were seeded buccal fat pad-derived stem...
Low surface energy and hydrophobicity of polymethyl methactylate (PMMA) are the main disadvantages this biomaterial. The aim study was to investigate effects a new coating process on characteristics properties PMMA. A combination temperature pressure used for deposition titanium dioxide (TiO2) PMMA coated with TiO2 thin films prepared by sputtering non-coated were considered as control groups. wettability, functional group, roughness determined contact angle measurement, Fourier transform...
The purpose of the present study is to characterize poly(d,l-lactide-co-glycolide) (PLGA) composite microcarriers for vascular endothelial growth factor (VEGF) delivery. To reduce initial burst release and protect bioactivity, VEGF encapsulated in soybean l-α-phosphatidylethanolamine (PE) l-α-phosphatidylcholine (PC) anhydrous reverse micelle (VEGF-RM) nanoparticles. Also, mesoporous nano-hexagonal Mg(OH)2 nanostructure (MNS)-loaded PE/PC (MNS-RM) nanoparticles are synthesized suppress...
Background: Asthma is an inflammatory airway disorder in which different immune cells the blood and lungs play a fundamental role. In asthma condition, inflammation accompanied by bronchial smooth muscle spasm cause obstruction. A study showed that high concentration of serotonin associated with intensity exacerbation disease. Other studies subtype receptor called 5-Hydroxytriptamine 2A (5- HT2A) can enhance T-cell blastogenesis production pro-inflammatory cytokines such as IFNγ. Objective:...
The role of air pollution in exacerbation allergic symptoms is well known. Several studies have shown the effect on serotonergic system. changes system could trigger several symptoms. 5-HT(3A) among serotonin receptors peripheral Blood Mononuclear Cells (PBMCs) as other cells. In present study we compared gene expression PBMCs asthmatic patients individuals who had been exposed to pollution. Normal were also included control for comparison expression. Following synthesis cDNA using mRNA...
Introduction: Induced pluripotent stem cells (iPSCs) can be generated from different source of with efficiencies. Two DNA methyltransferases DNMT1 and DNMT3A have been shown to regulate epigenetically the gene expression involved in cell viability reprogramming. L-ascorbic acid (L-AA) is a chemical factor that accelerate reprogramming. Here, we sought investigate effect L-AA on expressions. Materials Methods : First, mouse embryonic fibroblasts at passage 3 were cultured presence 10 µg/ml...