A5038911544- Mesenchymal stem cell research
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Circular RNAs in diseases
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- RNA Interference and Gene Delivery
- Renal and related cancers
- CRISPR and Genetic Engineering
- Acute Lymphoblastic Leukemia research
- Immune cells in cancer
- RNA modifications and cancer
- Virus-based gene therapy research
- Immune Response and Inflammation
- Pancreatic function and diabetes
- Hemoglobinopathies and Related Disorders
- 3D Printing in Biomedical Research
- Hematopoietic Stem Cell Transplantation
- Bone Tissue Engineering Materials
- Antimicrobial agents and applications
- Nanoparticle-Based Drug Delivery
Wenzhou Medical University
2019-2023
Tarbiat Modares University
2012-2022
Sarem Cell Research Center
2018-2020
Stem Cell Technology Research Center
2014-2017
Shahid Beheshti University of Medical Sciences
2015-2016
University of Tehran
2014
Tehran University of Medical Sciences
2013
In the embryonic heart, electrical impulses propagate in a unidirectional manner from sinus venosus and appear to be involved cardiogenesis. this work, aligned random polyaniline/polyetersulfone (PANI/PES) nanofibrous scaffolds doped by Camphor-10-sulfonic acid (β) (CPSA) were fabricated via electrospinning used conduct multidirectional fashion, respectively. A bioreactor was subsequently engineered apply cells cultured on PANI/PES scaffolds. We established cardiovascular disease-specific...
Abstract Objectives Human amniotic membrane ( HAM ) has been widely used in soft tissue engineering both its fresh form and decellularized; efficiency to aid treatment of burn injuries is well known. On the other hand, it reported clinically by several studies that human adipose‐derived stem cells hADSC are a promising cell source for therapy burns. Recently, we have new technique decellularization . In this study, potential prepared decellularized dHAM as viable support proliferation...
Abstract Background Cancer-associated fibroblasts (CAFs), one of the major components tumor stroma, contribute to an immunosuppressive microenvironment (TME) through induction and functional polarization protumoral macrophages. We have herein investigated contribution CAFs monocyte recruitment macrophage polarization. also sought identify a possible paracrine mechanism by which CAF-educated monocytes affect breast cancer (BC) cell progression. Methods Monocytes were educated primary normal...
To compare potential of four types stem cell in tissue engineering and regenerative medicine applications, osteogenic capacity newly introduced mesenchymal cells (MSCs) derived from buccal fat pads (BFP) (an adipose-encapsulated mass the oral cavity), was compared to those isolated bone marrow (BM-MSCs), adipose (AT-MSCs) unrestricted somatic (USSCs). Cells were cultured on poly (L-lactide) (PLLA) nanofibres, Bio-Oss(®)-coated PLLA (PLLA-Bio), culture plates (TCPS) as control.Capacity...
Aim: We investigated the delivery of sorafenib (SFB) to breast cancer spheroids by natural killer cell-derived exosomes (NK-Exos). Methods: SFB-NK-Exos were constructed electroporation. Their antitumor effects evaluated methyl thiazolyl tetrazolium, acridine orange/ethidium bromide, 4′,6-diamidino-2-phenylindole, annexin/propidium iodide, scratch and migration assay, colony formation, RT-PCR, western blot lipophagy tests. Result: The loading efficacy was 46.66%. SFB-NK-Exos-treated showed...
Stem cells can be obtained from a variety of sources. To compare the effect cell source on osteogenic differentiation potential, buccal fat pad-derived mesenchymal stem (BFP-MSCs), bone marrow-derived MSCs (BM-MSCs) and unrestricted somatic (USSCs) with different accessibility in time region, were cultured bioceramic (Bio-Oss®) coated electrospun polycaprolactone (PCL) scaffold (PCL-Bio). After characterization, proliferation investigated by MTT Alizarin red staining, alkaline phosphatase...
Breast cancer is the most commonly occurring among women. MicroRNAs as noncoding small RNA molecules play pivotal roles in cancer-related biological processes. Increased levels of microRNA-29a serum breast patients have been reported. Since heat shock proteins (HSPs) important cell events, quantitative fluctuations their cellular could be deemed key indicators how exerted treatment alters behavior. In this regard, using an antisense RNA, we attempted to investigate effects miR-29a knockdown...
Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with dire consequences and in urgent need of improved therapies. Compelling evidence indicates that damage or dysfunction AT2s central importance the development IPF. We recently identified novel AT2 subpopulation characterized by low SFTPC expression but enriched for PD-L1 mice. These cells represent quiescent, immature during normal homeostasis expand upon pneumonectomy (PNX) were consequently named...
Using stem cells to replace the lost beta is a hopeful strategy in treatment of diabetic patients. Furthermore, during cell culture and therapy, it need use substrate act as supportive matrix mimic 3D vivo microenvironment. Therefore, this study, human adipose‐derived were used differentiate into insulin‐producing (IPCs) on silk/polyethersulfone (PES) scaffold. After exposing differentiation media, 2D (silk/PES) cultured gradually aggregated formed spherical shaped clusters. The viability...
Breast cancer (BC) is one of the most common malignancies among women in world. There a global attempt to diagnose BC as early possible. Long noncoding RNAs (lncRNAs) are emerging novel targets and biomarkers for diagnosis prognosis. Aberrant expression lncRNAs associated with development, making them potential tumor marker BC. To investigate this possibility, we determined levels Down syndrome cell adhesion molecule-antisense RNA-1 (DSCAM-AS1) mitotically-associated long non-coding RNA...
β-thalassemia and sickle cell disease are hemoglobinopathies with reduced/absent β chains in the former dysfunctional latter. In both conditions, up-regulation of hemoglobin F through demethylation can alleviate symptoms. This be attained drugs such as thalidomide sodium butyrate.This study was performed on erythroid progenitors derived from CD133+ cord blood stem cells. Erythroid were treated butyrate single combined groups. Colony-formation potential each group evaluated by colony assay....
Kidney injuries and renal dysfunctions are one of the most important clinical problems, tissue engineering could be a valuable method for solving it. The objective this study was to investigate synergistic effect cell line-conditioned medium Polycaprolactone (PCL) nanofibers on differentiation human mesenchymal stem cells (MSCs). In current study, after isolation characterization, PCL nanofibrous scaffold fabricated using electrospinning methods characterized morphologically, mechanically,...
Colorectal cancer (CRC) is one of the most common cancers worldwide. Although colonoscopy considered as "Gold Standard" technique to detect CRC, its application invasive and cost incurred. Thus, noninvasive or minimally approaches are utmost importance. The aberrant expression some microRNAs (miRNAs, miRs) has been suggested in association with CRC pathogenesis. This study aimed validate if circulating serum miR-1229 miR-1246 diagnostic biomarkers for CRC.Serum samples were isolated from 45...