A5047570182- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- Glycosylation and Glycoproteins Research
- Hemoglobinopathies and Related Disorders
- Saffron Plant Research Studies
- Flavonoids in Medical Research
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Bone health and treatments
- Histone Deacetylase Inhibitors Research
- Pancreatic function and diabetes
- Acute Myeloid Leukemia Research
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Chronic Myeloid Leukemia Treatments
- PI3K/AKT/mTOR signaling in cancer
- Retinoids in leukemia and cellular processes
- Nanoparticle-Based Drug Delivery
Tarbiat Modares University
2016-2025
University of California, Los Angeles
2024
Imam Khomeini Hospital
2024
University of Tehran
2024
Yamaguchi University
2000-2009
Otsuka (Japan)
2002
Background MicroRNAs (miRNAs) are a group of endogenous small non-coding RNAs that regulate gene expression at the post-transcriptional level. A number studies have led to notion some miRNAs key roles in control pancreatic islet development and insulin secretion. Based on pattern, researchers this paper investigated differentiation human bone marrow mesenchymal stem cells (hBM-MSCs) by up-regulation miR-375 down-regulation miR-9 lentiviruses containing anti-miR-9. Methodology After 21 days...
We previously showed the anticancer effect of crocin, a saffron carotenoid, in both breast and gastric cancers animal models, but its mechanism action is not clearly known, yet. In this study, crocin on cell cycle regulators investigated. Female Wistar Albino rats were divided into two groups, with or without N-nitroso-N-methylurea (NMU) injection. After tumor formation, each group was subgroups, receiving vehicle only. 5 weeks, sacrificed tumors retained for pathologic investigation...
The survival and proliferation of human myeloma cells are considered to be heavily dependent on the microenvironment bone marrow (BM). This study confirmed that galectin-1 (Gal-1) SDF-1alpha were produced by mononuclear patients. addition Gal-1 a serum-free synthetic medium, maintained viability primary for 2 weeks similar before culture. While reduced viable cell number in CD45RA(+) B lines, it CD45(-) U266 CD45RA(-)RO(+) ILKM3 lines medium. was with transfection PTPRC (CD45) RA, -RB, or...
T-cell acute lymphoblastic leukemia (T-ALL) is caused by a defect in maturation to the mature T cell. T-ALL poor prognostic hematopoietic malignancy. In order establish successful therapeutic treatment plan, it essential understand biology of development and molecules that contribute this process. This study uses Jurkat cells, as well-established model for vitro investigate role microRNA (miRNA), miR-146a, on gene expressions involved differentiation.The permanent over-expression miR-146a...
Cord blood (CB) is known as a valuable source of hematopoietic stem cells (HSC). Identifying strategies that enhance expansion and maintain engraftment homing capacity HSCs can improve transplant efficiency. In this study, we examined different culture conditions on ex vivo CB-HSCs.In 4-5 units human CB in each 3 independent experiments were collected.CD34+ HSC was isolated, cultured the serum-free medium(Stem line II) supplemented with cytokines: FMS-like tyrosine kinase ligand (FLt3L),...
Abstract Aim Umbilical cord blood hematopoietic stem cells (UCB HSCs) have been considered for the treatment of hematological malignancies due to their noninvasive collection, greater capacity expansion, and remarkable tolerance HLA mismatch in transplantation. On other hand, most considerable limitation these is inadequate amount CD34 + HSCs which leads delayed engraftment. The aim this study was expansion by coculturing with mesenchymal (MSCs) overexpressing stromal cell‐derived factor‐1,...
Umbilical cord blood (UCB) is an accessible and effective alternative source for hematopoietic stem cell (HSC) transplantation. Although the clinical application of UCB transplantation has been increased recently, quantitative limitation HSCs within a single unit still remains major hurdle In this study we used microcarrier beads to evaluate ex vivo expansion UCB-derived in co-cultured with mesenchymal cells (MSC).In experimental study, expand MSCs. We investigated simultaneous co-culture...
Abstract The serum levels of an adrenal sex hormone, dehydroepiandrosterone sulfate (DHEA-S), are significantly more decreased in human myelomas compared with the reduction brought by physiologic decline age. In order to clarify effect DHEA on myeloma cells, we investigated whether and DHEA-S could inhibit interleukin-6 (IL-6) production bone marrow mononuclear cells proliferation from patients myeloma. suppressed IL-6 a stromal cell line, KM-102, as well Furthermore, inhibited vitro growth...