A5045883082- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Erythrocyte Function and Pathophysiology
- Multiple Myeloma Research and Treatments
- Extracellular vesicles in disease
- Chronic Lymphocytic Leukemia Research
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Bone health and treatments
- 3D Printing in Biomedical Research
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Blood groups and transfusion
- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Synthesis of Tetrazole Derivatives
Tarbiat Modares University
2014-2023
Advanced Tissue (United States)
2022
Osun State University
2009
Differentiation of mesenchymal stem cells (MSCs) into neuron has great potential in therapy damaged nerve tissue. It been shown that three-dimensional biomaterials have ability to up regulate the expression neuronal proteins. In this study, O2 plasma technology was used enhance hydrophilicity poly (ε-caprolactone) (PCL) toward selective differentiation MSCs neural cells. Random and aligned PCL nanofibers scaffolds were fabricated by electrospinning method their physicochemical mechanical...
The therapeutic properties of tin nanoparticles have been proved in recent years. One their probable effects is anti‐anemia. In this study, were synthesized and characterized aqueous medium using Ziziphora clinopodioides Lam leaf extract as the reducing stabilizing agent. We also assessed antihemolytic anemia potential (SnNPs) an animal model hemolytic anemia. Tin many techniques including Fourier transform‐infrared UV‐visible spectroscopy, X‐ray diffraction (XRD), energy dispersive...
Recent studies have devoted much attention to non-protein-coding transcripts in relation a wide range of malignancies. MALAT1, long non-coding RNA, has been reported be associated with cancer progression and prognosis. Thus, we here determined MALAT1 gene expression chronic lymphocytic leukemia (CLL), genetically heterogeneous disease, explored its possible relationships cytogenetic abnormalities.MALAT1 level was evaluated using real-time quantitative reverse transcription polymerase chain...
T-cell acute lymphoblastic leukemia (T-ALL) is caused by a defect in maturation to the mature T cell. T-ALL poor prognostic hematopoietic malignancy. In order establish successful therapeutic treatment plan, it essential understand biology of development and molecules that contribute this process. This study uses Jurkat cells, as well-established model for vitro investigate role microRNA (miRNA), miR-146a, on gene expressions involved differentiation.The permanent over-expression miR-146a...
Micro RNAs are a class of small non-coding which has been recently shown to play crucial role in major cellular processes such as development and differentiation through post-transcriptional regulation. The these epigenetic elements also demonstrated hematopoietic lineage there is large body evidence that miR-424 responsible for monocyte differentiation. Our goal was examine the effect over-expression on defeating maturation blockage monoblastic cell line U937. permanent established using...
This study aimed to investigate the effect of pentoxifylline on complications prolonged usage morphine upon testis and sperm parameters rats. In this study, forty male Wistar rats were divided into five groups (n = 8) treated for 56 days only saline, morphine, pentoxifylline, + naltrexone morphine. The diameters seminiferous tubules, maturity germ line epithelium evaluated. expression inflammatory-related factors in tissues also investigated at gene protein levels. data calculated by one-way...
Umbilical cord blood (UCB) is an accessible and effective alternative source for hematopoietic stem cell (HSC) transplantation. Although the clinical application of UCB transplantation has been increased recently, quantitative limitation HSCs within a single unit still remains major hurdle In this study we used microcarrier beads to evaluate ex vivo expansion UCB-derived in co-cultured with mesenchymal cells (MSC).In experimental study, expand MSCs. We investigated simultaneous co-culture...
β-thalassemia and sickle cell disease are hemoglobinopathies with reduced/absent β chains in the former dysfunctional latter. In both conditions, up-regulation of hemoglobin F through demethylation can alleviate symptoms. This be attained drugs such as thalidomide sodium butyrate.This study was performed on erythroid progenitors derived from CD133+ cord blood stem cells. Erythroid were treated butyrate single combined groups. Colony-formation potential each group evaluated by colony assay....
Background: Acute T lymphoblastic Leukemia (T-ALL) is a highly aggressive hematologic malignancy. Chemotherapy resistance one of the most important challenges in T-ALL treatment. Alterations cellular signaling pathways such as Notch1 and PI3K/AKT/mTOR play role cell proliferation, survival, to chemotherapy. Combination inhibitors an interesting rational strategy treatment T-ALL. Interaction AZD5363 inhibitor PI3k/AKT/mTOR Compound E pathway was investigated pre-clinical model. Materials...