A5083998511- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Electrospun Nanofibers in Biomedical Applications
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
- Pomegranate: compositions and health benefits
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
- Drug-Induced Hepatotoxicity and Protection
- Silk-based biomaterials and applications
- Vasculitis and related conditions
- Polymer Nanocomposites and Properties
- Cell Adhesion Molecules Research
- Thermal and Kinetic Analysis
- Toxin Mechanisms and Immunotoxins
- Pluripotent Stem Cells Research
- Ginkgo biloba and Cashew Applications
- Phytochemical compounds biological activities
- Bioactive Compounds in Plants
- Polymer Synthesis and Characterization
- Nephrotoxicity and Medicinal Plants
Golestan University
2018-2025
Golestan University of Medical Sciences
2018-2025
Tehran University of Medical Sciences
2017-2024
Tabriz University of Medical Sciences
2012-2014
University of Tabriz
2013
Rheumatoid arthritis (RA) is an autoimmune disease that marked by inflammatory response. PNPLA2 (phospholipase patatin-like) which encodes ATGL (adipose triglyceride lipase) also been identified as playing in inflammation. G0S2 (G0/G1) switch gene has one of the selective inhibitors ATGL. and may be factors can help predict relationship between molecules affecting inflammation, well identify pathways through genes involved metabolic pathway. In present study, we analyzed expression levels...
Abstract Targeted therapy using specific monoclonal antibodies (mAbs) conjugated to chemotherapeutic agents or toxins has become one of the top priorities in cancer therapy. Antibody–drug conjugates (ADCs) are emerging as a promising strategy for cancer‐targeted In this study, trastuzumab, humanized anti‐HER2 antibody, was reduced by dithiothreitol and microtubule‐disrupting agent monomethyl auristatin E (MMAE) through valine‐citrulline peptide linker (trastuzumab‐MC‐Val‐Cit‐PABC‐MMAE...
Punica granatum L. var. (Pomegranate), an herbaceous plant found in Iran, The aim of this study was to investigate the cytotoxic effects, induction apoptosis, and mechanism cell death ethanol extract from spinosa on mouse fibrosarcoma line, WEHI-164.Various parts herbs were extracted fruit using as solvent, cytotoxicity viability ethanolic determined by MTT assay. To determine whether necrosis or apoptosis is predominant cause death, detection performed ELISA method. confirmed terminal...
The Punica granatum L. var. (pomegranate) has been demonstrated to exert antitumor effects on various types of cancer cells. present study aimed evaluate the medicinal herbs spinosa (apple punice) that are native Iran. This was determined test possible cytotoxic activity and induction apoptosis human prostate cell lines. effect ethanol extracts inhibition proliferation assessed by MTT colorimetric assay. PC3 lines treated with were analyzed for death detection (ELISA) TUNEL Dye exclusion...
MSCs are a part of the tumor microenvironment, which secrete cytokines and chemokines. They can affect metastasis growth tumors. metastamiRs newly recognized regulatory elements pathway involved in epithelial-to-mesenchymal transition (EMT).
Background: Targeting CD20 antigen on B-lymphocytes provides good opportunity for management of the target cells in patients with B-cell malignancies. By advent hybridoma technology, monoclonal antibodies applications exert extensive changes i
Reduction/alkylation is one of the leading strategies for development antibody drug conjugates (ADCs). Precise control reduction process would not only yield a defined number free thiols per but also result in more homogenous conjugates.In present study, we investigated effect various dithiothreitol (DTT) concentrations, temperature conditions, and DTT exposure times on reduction. After reduction, Ellman's test SDS-PAGE analysis were used to evaluate produced confirm process,...
Abstract This paper reports walnut shell ash (WNS ash) a sustainable material for tubeless inner liner application. replaced the commercial magnesium oxide (MgO).The WNS generated at 550°C, is found to have 72% alkali metal and earth metal, whereas MgO shows 95% metal. It was observed in this study perform as cure retarder bromobutyl rubber/bromo isobutylene isoprene rubber‐based tube less compound its performance similar with MgO; however, not exactly equivalent. Optimum retardation 0.40...
Abstract Mesenchymal stem cells and macrophages (MQ) are two very important involved in the normal wound healing process. It is well understood that topological cues mechanical factors can lead to different responses MQ by influencing their shape, cytoskeleton proliferation, migration, differentiation, which play an essential role success or failure of biomaterial implantation more importantly healing. On other hand, polarization from proinflammatory (M1) prohealing (M2) phenotypes has a...
Monoclonal antibodies are important tools used in basic research as well as, diagnosis, imaging and treatment of immunodeficiency diseases, infections cancers. The purpose this study was to produce large scale monoclonal antibody against CD20 order diagnostic application leukemia lymphomas disorders.Hybridoma cells that human were administered into the peritoneum Balb/c mice which have previously been primed with 0.5 ml Pristane. After twelve days, approximately 7 ascetic fluid harvested...
Mesenchymal stem cells (MSCs) were isolated from various sources, including types of tumors. However choosing an appropriate isolation method is important step in obtaining with optimal quality and yield companion economical considerations. The purpose this study was to isolate more pure MSCs human breast tumor tissue by a modified explant culture method.The tissues (n = 8) cut into 1 3-mm cube-like pieces (explant). Each placed well 24-well format plates, cultured Dulbecco's Modified...
Despite all the advances in production of transgenic mice, efficiency these animal models is still low. Given that expression developmental genes has a critical role growth and development embryo, we determined pattern pluripotency, trophectoderm imprinting Rag1 (recombination-activating gene 1) knocked-out blastocysts resulting from microinjection CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) constructs into zygote cytoplasm C57bl6 mice....
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Shahneh F, Babalo Z, Baradaran B, Sepehr K. Review paperInsights into Behçet’s disease. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2012;29(6):461-466. doi:10.5114/pdia.2012.32395. APA Shahneh, F., Babalo, Z., Baradaran, B., & Sepehr, (2012). Alergologii, 29(6), 461-466. https://doi.org/10.5114/pdia.2012.32395 Chicago Fatemeh Zare, Zohreh Behzad Koushan Sineh Sepehr. 2012....
Deep skin wounds require grafting with a substitute for treatment. Despite many attempts in the development of an affordable and efficient substitute, repair deep still remains challenging. In current study, we present 3D sponge composite made from human placenta (a disposable organ) sodium alginate exceptional properties tissue engineering applications. Toward this goal, different proportions (Alg) decellularized scaffold (DPS) were composited freeze-dried to generate desired biomechanical...