A5049396220- Multiple Sclerosis Research Studies
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Cerebral Palsy and Movement Disorders
- Peripheral Neuropathies and Disorders
- Stroke Rehabilitation and Recovery
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Laser Applications in Dentistry and Medicine
- Mycobacterium research and diagnosis
- Viral Infections and Immunology Research
- Ultrasound and Hyperthermia Applications
- Spinal Hematomas and Complications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Viral Infections and Vectors
- Fungal Plant Pathogen Control
- Cytokine Signaling Pathways and Interactions
- Pain Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Medical and Biological Ozone Research
- Systemic Sclerosis and Related Diseases
- Vector-borne infectious diseases
- Extracellular vesicles in disease
- Pharmacological Effects and Toxicity Studies
- Telemedicine and Telehealth Implementation
- Ion channel regulation and function
Lillebaelt Hospital
2018-2025
University of Southern Denmark
2014-2025
Haukeland University Hospital
2023
Danish Multiple Sclerosis Center
2020
Odense University Hospital
2011-2020
Herlev Hospital
2020
Aalborg University Hospital
2020
Aalborg University
2020
Kolding Hospital
2018-2020
Regional Health
2020
Background: Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, an uninvestigated ‘window of opportunity’ exists early the disease course. Objective: To investigate effect exercise on relapse rate, global brain atrophy secondary magnetic resonance imaging (MRI) outcomes. Methods: This randomized controlled trial ( n = 84, duration <2 years) included 48 weeks...
Objective: We aimed to evaluate the effect of slow-release (SR) Fampridine on multiple outcome measures reflecting different domains, and compare responsiveness Six Spot Step Test (SSST) Timed 25 Foot Walk (T25FW). Methods: For this study 108 participants were included. On day 0 they tested with T25FW, SSST, 9-Hole Peg (9-HPT), 5 Times Sit-To-Stand test (5-STS) Symbol Digit Modalities (SDMT). Four weeks treatment SR 10 mg BID was commenced. Participants again after 26–28 days treatment....
To determine whether 24 weeks of high-intensity progressive aerobic exercise (PAE) affects brain MRI measures in people with multiple sclerosis (MS).We conducted a randomized, controlled, phase 2 trial (with crossover follow-up) including an group (supervised PAE followed by self-guided physical activity) and waitlist (habitual lifestyle supervised PAE). Mildly to severely impaired patients MS aged 18-65 years were randomized (1:1). The primary outcome was percentage volume change (PBVC)...
Background: In multiple sclerosis (MS), the educational gradient in diagnostic and disease-modifying treatment (DMT) delays is sparsely examined, results are mixed. Objectives: Among patients with relapsing-remitting MS (RRMS), we aimed to examine delay initiation of first DMT. Design: A nationwide cohort study. Methods: We linked Danish Multiple Sclerosis Registry other registries. Diagnostic was evaluated 4344 ⩾20 years at clinical onset from January 1, 2012, onwards, diagnosed by March...
Objectives Fatigue and walking impairment are disabling symptoms of multiple sclerosis (MS). We investigated the effects progressive aerobic exercise (PAE) on fatigue, walking, cardiorespiratory fitness (VO2max), quality life in people with MS (pwMS). Materials & Methods Randomized controlled trial (1:1 ratio, stratified by sex) a 24-week crossover follow-up intention-to-treat analysis. Allocation to an (24 weeks PAE followed self-guided physical activity) waitlist habitual lifestyle PAE)...
The aim of this double-blind study was to evaluate the effect low power Ga-Al-As laser treatment on chronic pain related osteoarthritis knee with periarticular tender points. Twenty-nine out-patients uni- or bilateral were included and randomly assigned either placebo laser. Fourteen patients received active all completed study. variables daily levels pain, analgesic requirements, palpation tenderness isokinetic quadriceps strength. Each patient participated in for 9 weeks registered level...
Background Cognitive impairment is highly prevalent in multiple sclerosis (MS). Progressive aerobic exercise (PAE) represents a promising approach toward preservation or even improvement of cognitive performance people with MS (pwMS). Objective To investigate the effects PAE on domains information processing, learning and memory, verbal fluency pwMS. Methods This randomized controlled trial included an ( n = 43, 24 weeks supervised PAE, followed by self-guided physical activity) waitlist...
Molecular methods for diagnosing Lyme neuroborreliosis (LNB) have shown suboptimal diagnostic sensitivities. The objective of this study was to improve the clinical sensitivity PCR detection Borrelia burgdorferi sensu lato spirochetes by inoculating cerebrospinal fluid (CSF) from patients suspected LNB directly into culture medium at time lumbar puncture, with pursuing enrichment before analysis. Adult symptoms suggestive were prospectively enrolled two hospitals in Region Southern Denmark....
Abstract The aim of this study was to evaluate whether the six‐spot‐step test (SSST) is more suitable for monitoring walking ability in patients with chronic inflammatory polyneuropathy than timed 25‐foot‐walking (T25FW). In SSST, participants have walk as quickly possible across a field measuring 1 × 5 m, while kicking blocks out five circles on floor. Sixty‐two and 61 controls performed SSST T25FW. Patients also overall disability sumscore, INCAT sensory Medical Research Council...
(1) Background: Cognitive impairment is highly prevalent in multiple sclerosis (MS). Staying physically fit may be associated with preservation of cognitive performance persons MS (pwMS); (2) Objective: To investigate the association between aerobic capacity and domains information processing, learning memory, verbal fluency as well single composite z-scores Brief Repeatable Battery Neuropsychological tests (BRBNT) pwMS; (3) Methods: All subjects first performed BRBNT then a maximal oxygen...
Objective To assess the risk of losing income from salaries and disability pension for multiple sclerosis patients with a clinically stable disease course 3 years after start disease-modifying therapy (DMT). Methods Data Danish Multiple Sclerosis Registry were linked to other nationwide population-based databases. We included who started treatment DMT between 2001 2014. Patients categorised into group (No Evidence Disease Activity (NEDA-2)) active (relapse activity or 6-month confirmed...
Dimethyl fumarate (DMF, Tecfidera®) is a first-line disease-modifying therapy for relapsing-remitting multiple sclerosis. Lymphopenia frequent reason discontinuation in fumarate-treated patients. Management strategies to minimize risk of lymphopenia are warranted.The aims this study were investigate the correlation body mass index (BMI), baseline absolute lymphocyte count (ALC), age and sex with DMF-induced MS patients.The was retrospective cohort 452 patients who had been prescribed DMF at...
Treatment adherence is a prerequisite for treatment success and therefore an important consideration to assure that therapeutic goals are achieved both from patient point of view optimal health care resource utilization. Published data on with fingolimod (Gilenya®) limited. Therefore, this study investigated in patients relapsing-remitting multiple sclerosis (RRMS) treated Denmark.This was 24-month, multicenter, open-label study, investigating adherence, satisfaction, motivation,...
Peripheral cytokine levels may serve as biomarkers for treatment response and disease monitoring in patients with multiple sclerosis (pwMS). The objectives were to assess changes plasma PwMS after 14 days of fampridine explore correlations between performance measures biomarkers. We included 27 PwMS, women 13 men, aged 52.0 ± 11.6 years, a duration 17 8.5 an Expanded Disability Status Scale 6 [IQR 5.0/6.5]. Gait hand function assessed using tests completed prior treatment. Venous blood was...
Lyme neuroborreliosis (LNB) is the most prevalent nervous system bacterial infection in Denmark. In a young man with LNB, brain MRI and cerebrospinal fluid (CSF) demonstrated findings compatible multiple sclerosis. This case report underlines requirement for testing intrathecal Borrelia antibody production when number of cells CSF low or even normal. It also demonstrates unchanged diagnostic delay NBL observed during last 20 years.
Body weight unloaded treadmill training has shown limited efficacy in further improving functional capacity after subacute rehabilitation of ischemic stroke patients. Dynamic robot assisted bodyweight unloading is a novel technology that may provide superior stimuli and continued improvements individuals with residual impairments the chronic phase insult. The aim present study to investigate effect dynamic robot-assisted versus standard training, initiated 6 months post-stroke, on motor...