A5053164744- Pain Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Pain Management and Placebo Effect
- Rheumatoid Arthritis Research and Therapies
- Toxin Mechanisms and Immunotoxins
- Hereditary Neurological Disorders
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
Odense University Hospital
2017-2019
University of Copenhagen
1990
Herlev Hospital
1990
To assess whether monthly treatment with intravenous methylprednisolone enhances or accelerates the effect of disease modifying drugs in patients rheumatoid arthritis.A 12 month double blind, placebo controlled, multicentre trial which active arthritis were randomly allocated to receive pulses either saline every four weeks for six months. At start pulse all started on penicillamine azathioprine.Four rheumatology departments Denmark.97 Patients (71 women, 26 men) aged 23-84 (mean 60) who had...
Abstract The aim of this study was to evaluate whether the six‐spot‐step test (SSST) is more suitable for monitoring walking ability in patients with chronic inflammatory polyneuropathy than timed 25‐foot‐walking (T25FW). In SSST, participants have walk as quickly possible across a field measuring 1 × 5 m, while kicking blocks out five circles on floor. Sixty‐two and 61 controls performed SSST T25FW. Patients also overall disability sumscore, INCAT sensory Medical Research Council...
The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) removes temozolomide-induced alkylation, thereby preventing damage and cytotoxicity. We investigated the prognostic effect of different MGMT methylation levels on overall progression-free survival in 327 patients with primary glioblastoma undergoing standard treatment. obtained level 4 CpG sites using pyrosequencing. association between was Cox proportional hazards model an extension to detect time-varying effects. found...
Abstract Background Neuropathic pain is a common condition that has major negative impact on health-related quality of life. However, despite decades research, it remains difficult to treat neuropathic pain. Lacosamide sodium-channel blocker efficacious in animal models In humans, its effect inconclusive, based inconsistent results and very large placebo responses. Previous trials have not used patient stratification or looked for predictors response. Methods This study will be conducted as...
Standard treatment for patients with glioblastoma multiforme (GBM) consists of surgery, radiotherapy and concomitant adjuvant the alkylating agent temozolomide (TMZ). The repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) removes alkyl groups thereby preventing DNA damage apoptosis. However, methylation MGMT promoter gene causes protein deficiency a better response towards TMZ, which may affect patient survival. In population-based cohort 508 primary GBMs diagnosed between 2005 2014...