A5025641135- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Rheumatoid Arthritis Research and Therapies
- Systemic Sclerosis and Related Diseases
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Viral Infections and Immunology Research
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Family Support in Illness
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Monoclonal and Polyclonal Antibodies Research
- Mycobacterium research and diagnosis
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Bacterial Infections and Vaccines
- Amyotrophic Lateral Sclerosis Research
- Migraine and Headache Studies
- Acute Lymphoblastic Leukemia research
- Immune Response and Inflammation
- T-cell and Retrovirus Studies
- Immunodeficiency and Autoimmune Disorders
- Health Systems, Economic Evaluations, Quality of Life
Copenhagen University Hospital
2011-2025
Danish Multiple Sclerosis Center
2014-2025
Rigshospitalet
2014-2025
Aarhus University Hospital
2012-2024
Aalborg University Hospital
2005-2021
Glostrup Hospital
2006-2020
Aarhus University
2005-2019
University of Copenhagen
2006-2019
University of Southern Denmark
2017-2018
Odense University Hospital
2009-2018
The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as the pathological correlates different clinical characteristics patients with primary and secondary disease. We analysed brains spinal cords from 51 by planimetry. Thirteen disease were compared 34 In sclerosis, we found larger brain plaques, more demyelination total higher loads active addition, density plaques high-grade inflammation was highest remained ∼18% than after adjustments for other plaque...
Background: Obesity in late adolescence has been associated with an increased risk of multiple sclerosis (MS); however, it is not known if body size childhood MS risk. Methods: Using a prospective design we examined whether mass index (BMI) at ages 7–13 years was among 302,043 individuals the Copenhagen School Health Records Register (CSHRR). Linking CSHRR Danish registry yielded 774 cases (501 girls, 273 boys). We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95%...
Background: Pain is an important symptom in patients with multiple sclerosis (MS).The estimated pain prevalence varies between 30% and 90%.To our knowledge, previous studies do not include a whole population sample of MS.Objective: To assess its clinical characteristics impact on daily life MS reference group.Design: Postal survey.
<b>Background: </b> Neutralizing antibodies (NABs) occur frequently in patients receiving interferon (IFN)-beta for multiple sclerosis (MS), but it is unclear whether occurrence of NABs predictive the persistence during continued IFN-beta therapy. <b>Methods: The authors used an antiviral neutralization bioassay to measure blindly from 6 months up 78 with MS who were followed at least 24 treatment IFN-beta. Patients classified into three groups: 1) persistently NAB-negative patients, defined...
Infectious mononucleosis caused by the Epstein-Barr virus has been associated with increased risk of multiple sclerosis. However, little is known about characteristics this association.To assess significance sex, age at and time since infectious mononucleosis, attained to developing sclerosis after mononucleosis.Cohort study using persons tested serologically for Statens Serum Institut, Danish Civil Registration System, National Hospital Discharge Register, Multiple Sclerosis...
<h3>Objective</h3> To describe the pattern of development incidence multiple sclerosis (MS) over 60 years in Denmark with age-period-cohort analyses and seasonality birth. <h3>Methods</h3> Data on virtually all patients onset MS have since 1950 been prospectively recorded kept Danish Multiple Sclerosis Registry sources notification. Annualized rates per 100,000 were directly standardized to European Standard Population. <h3>Results</h3> We registered 19,536 cases clinical confirmed from...
To assess long-term treatment effectiveness of disease-modifying therapy (DMT) initiated early in disease course versus later start.We included all Danish patients with multiple sclerosis (MS) treated DMT through two nationwide population-based MS registries. Patients were categorized as if started within 2 years after the first symptom (n = 2316) and between 8 clinical onset 1479). We compared time from start to progression an Expanded Disability Status Scale (EDSS) score 6 mortality...
<h3>Objectives</h3> To estimate the nationwide population-based incidence, prevalence, and geographical distribution of neuromyelitis optica (NMO) spectrum disorder (NMOSD) in Denmark based on 2015 International Panel for NMO Diagnosis (IPND) criteria. <h3>Methods</h3> We conducted a multicentre, historically prospective study. Data were sourced from Danish National Patient Registry, Multiple Sclerosis departments neurology, laboratories providing aquaporin-4 antibody test. Cases selected...
Cancer occurrence in patients with multiple sclerosis (MS) has been little studied, but associations brain tumours, breast cancer, Hodgkin lymphoma and nasopharyngeal carcinoma have suggested. We took advantage of population-based registers MS cancer to assess the risk following diagnosis MS. Patients registered Danish Multiple Sclerosis Register were linked obtain information on occurrence. The ratio observed number expected cancers based incidence rates, i.e., standardised (SIR), served as...
Multiple sclerosis affects young and middle-aged people often leads to physical cognitive handicaps. There is a need for detailed knowledge of the social consequences disease. We aim here describe course working life career multiple patients at time onset thereafter, in terms probability early pension income development. All 2538 with Denmark disease between 1980 1989, identified through Danish MS-Registry, were included this study. Twenty matched control persons per patient randomly drawn...
Background Both human leukocyte antigen (HLA)-DRB1*15 and Epstein-Barr virus infection presenting as infectious mononucleosis (IM) are recognized risk factors for multiple sclerosis (MS). However, their combined effect possible interaction on MS is not known. Objective To assess the association between HLA-DRB1*15 of in persons with without IM. Methods We compared prevalence DRB1*15 patients ( n = 76) 1,836) IM corresponding distributions blood donors 62) 484) histories. This allowed us to...
Multiple sclerosis is an inflammatory disease of the central nervous system unknown aetiology. Its prevalence varies by ethnicity and place: persons northern European descent are at increased risk while living lower latitudes appear to be protected against disease. The Danish Sclerosis Registry a national registry established in 1956 after population-based survey which receives information from numerous sources. It considered more than 90% complete, with validity 94%. Using data Registry, we...
To investigate the effect of chronic comorbidity on time diagnosis multiple sclerosis (MS) and mortality in MS.We conducted a population-based, nationwide cohort study including all incident MS cases Denmark with first symptom between 1980 2005. diagnosis, we compared individuals without using multinomial logistic regression. mortality, used Cox regression time-dependent covariates, following participants from clinical onset until endpoint (death) or to end study, censuring at emigration.We...
Abstract Objectives The Danish Multiple Sclerosis Registry is the oldest operative and nationwide MS registry. We present with its history, data collection, scientific contribution, national international research collaboration. Materials Methods Detailed description of completeness, quality optimizing procedures, funding, legal, ethical protection issues are provided. Results total number registered cases clinical isolated syndrome multiple sclerosis since 1956 was by start May 2020 30,023...
Background: The optimal timing of treatment starts for achieving the best control on long-term disability accumulation in multiple sclerosis (MS) is still to be defined. Objective: aim this study was estimate time start disease-modifying therapies (DMTs) prevent MS, using a pooled dataset from Big Multiple Sclerosis Data (BMSD) network. Methods: Multivariable Cox regression models adjusted first disease onset (in quintiles) were used. To mitigate impact potential biases, set pairwise...
To quantify sex differences in activity and severity of multiple sclerosis (MS) how it depends on disease duration time since clinical onset.All Danish citizens with onset relapsing MS 1996 who have received disease-modifying therapy been followed annual or biannual control visits mandatory notification the Multiple Sclerosis Registry. Men women were compared by inverse probability being female. Relapse rates changes Expanded Disability Status Scale (EDSS) scores analysed weighted general...
Type 1 diabetes mellitus (T1D) and multiple sclerosis (MS) contribute considerably to the burden of autoimmune diseases in young adults. Although HLA patterns T1D MS are considered mutually exclusive, individual familial co-occurrence 2 has been reported.To assess by estimating risk for patients with first-degree relatives MS.Two population-based disease registers, Danish Hospital Discharge Register Multiple Sclerosis were used identify T1D, defined as whom was diagnosed before age 20 years...
To investigate whether the efficacy of interferon-beta (IFNbeta) treatment relapsing-remitting MS (RR-MS) was influenced by type, dose, and frequency administration.From June 1996 through October 1997, authors offered participation to all Danish RR-MS patients who met following criteria: definite MS, at least two relapses within 2 years, age 18 55, an Expanded Disability Status Scale (EDSS) score < or = 5.5. The study multicenter, controlled, open-label, randomized, head-to-head comparing...
Previous studies of natalizumab (Tysabri) in relapsing multiple sclerosis (MS) patients have included with moderate disease activity. We studied a patient population high activity.We analyzed data from 234 consecutive, natalizumab-treated patients, followed for at least 3 months. Three groups were eligible therapy: two or more documented relapses sustained increase 2 EDSS points on modifying therapy (DMT) the previous year; switching mitoxantrone; and very active MS as de novo therapy.During...
Background: There is a need for follow-up studies of the familial situation multiple sclerosis (MS) patients. Objectives: To evaluate probability MS patients to remain in marriage or relationship with same partner after onset comparison population. Patients and methods: All 2538 Danes 1980—1989, retrieved from Danish MS-Registry, 50,760 matched randomly drawn control persons were included. Information on family status was Statistics Denmark. Cox analyses used as starting point. Results: Five...