A5101787724- Primate Behavior and Ecology
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Mosquito-borne diseases and control
- Animal Behavior and Reproduction
- Genetics, Aging, and Longevity in Model Organisms
- Regulation of Appetite and Obesity
- Multiple Sclerosis Research Studies
- Evolutionary Psychology and Human Behavior
- Neuroendocrine regulation and behavior
- Single-cell and spatial transcriptomics
- Gut microbiota and health
- Polyomavirus and related diseases
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Infant Nutrition and Health
- Monoclonal and Polyclonal Antibodies Research
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Pluripotent Stem Cells Research
Texas Biomedical Research Institute
2015-2025
The University of Texas at San Antonio
2014-2024
The University of Texas Health Science Center at San Antonio
2013-2024
Weatherford College
2023
Texas A&M University – San Antonio
2014-2021
Hudson Institute
2018-2020
Longevity Biotech (United States)
2019-2020
Association of American Universities
2018-2020
George Washington University
2018-2020
University of California, Davis
2020
We report the whole-genome sequence of common marmoset (Callithrix jacchus). The 2.26-Gb genome a female was assembled using Sanger read data (6×) and shotgun strategy. A first analysis has permitted comparison with genomes apes Old World monkeys identification specific features that might contribute to unique biology this diminutive primate, including genetic changes may influence body size, frequent twinning chimerism. observed positive selection in growth hormone/insulin-like factor genes...
The common marmoset ( Callithrix jacchus ) is poised to become a standard nonhuman primate aging model. With an average lifespan of 5 7 years and maximum 16½ years, marmosets are the shortest-lived anthropoid primates. They display age-related changes in pathologies that mirror those seen humans, such as cancer, amyloidosis, diabetes, chronic renal disease. also predictable differences lean mass, calf circumference, circulating albumin, hemoglobin, hematocrit. Features spontaneous sensory...
<b>Background: </b> Neutralizing antibodies (NABs) occur frequently in patients receiving interferon (IFN)-beta for multiple sclerosis (MS), but it is unclear whether occurrence of NABs predictive the persistence during continued IFN-beta therapy. <b>Methods: The authors used an antiviral neutralization bioassay to measure blindly from 6 months up 78 with MS who were followed at least 24 treatment IFN-beta. Patients classified into three groups: 1) persistently NAB-negative patients, defined...
The formation of viable genetic chimeras in mammals through the transfer cells between siblings utero is rare. Using microsatellite DNA markers, we show here that chimerism marmoset (Callithrix kuhlii) twins not limited to blood-derived hematopoietic tissues as was previously described. All somatic tissue types sampled were found be chimeric. Notably, demonstrated present germ-line tissues, an event never before documented naturally occurring a primate. In fact, chimeric marmosets often...
Reconstitution of germ cell fate from pluripotent stem cells provides an opportunity to understand the molecular underpinnings development. Here, we established robust methods for induced (iPSC) culture in common marmoset (Callithrix jacchus [cj]), allowing stable propagation undifferentiated state. Notably, iPSCs cultured on a feeder layer presence WNT signaling inhibitor upregulated genes related ubiquitin-dependent protein catabolic processes and enter permissive state that enables...
Abstract Zika virus (ZIKV) infection during pregnancy poses significant threats to maternal and fetal health, leading intrauterine demise severe developmental malformations that constitute congenital syndrome (CZS). As such, the development of a safe effective ZIKV vaccine is critical public health priority. However, safety efficacy such remain uncertain. Historically, conduct clinical trials in pregnant women has been challenging. Therefore, clinically relevant animal models are high demand...
Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed determine if phenotypes body composition, hematology, morphometrical measures were age or risk death. We found that cause mortality older marmosets more likely be due cardiac chronic kidney than younger marmosets. Older have decreased fat...
Recently, naturally occurring antibodies to IFN-alpha were discovered in a few systemic lupus erythematosus (SLE) and cancer patients; however, most patients monitored for anti-IFN before treatment, no found. In an attempt explain the 'IFN-blocking effect' that we observed all serum samples investigated 200 sera from healthy blood donors. We isolated globulin fraction, used rabbit anti-human IgG IgM columns, protein A columns T-gel affinity chromatography isolate human IgM. All sample...
This report explores aspects of developing obesity in two captive populations common marmosets (Callithrix jacchus), a small primate with short lifespan that may be value modeling chronic acquisition and its lifetime effects. Two were examined. In study 1, body composition, lipid parameters, glucose metabolic parameters measured population 64 adult animals. Animals classified as obese (>80th percentile relative fat based on sex) displayed both dyslipidemia (higher triglyceride very...
Assessing body weight is common practice for monitoring health in marmosets ( Callithrix jacchus ). Body composition analysis via quantitative magnetic resonance (QMR) a more in-depth assessment allowing measurements of lean and fat mass, but it expensive remains unavailable to most. Alternatively, condition scoring (BCS) an instrument-free method visually inspecting palpating tissue. Animals are rated mass abundance, using ordinal scale with species-specific descriptions as reference....
This paper demonstrates and characterizes naturally occurring antibodies to interferon (IFN) in human IgG preparations. In vitro neutralization of the antiviral effect IFN alpha beta, but not gamma, was observed 12 15 normal The neutralizing capacity higher against rIFN 2A 2C than lymphoblastoid beta. Frühsommer meningoencephalitis hyperimmune hepatitis-B showed potent neutralization, whereas anti-rhesus D-, anti-rabies-, anti-tetanus weak neutralization. Saturable binding 125I-rIFN...
This report is the first description of dosing procedures, pharmacokinetics, biochemical action, and general tolerability antiaging drug rapamycin in common marmoset, a small short-lived monkey. Eudragit-encapsulated was given orally to trained marmosets short-term (3 weeks) long-term (14 months) study. Circulating trough levels (mean = 5.2 ng/mL; 1.93-10.73 ng/mL) achieved at roughly 1.0 mg/kg/day comparable those reported studies rodents within therapeutic range for humans. Long-term...
Rapamycin has been shown to extend lifespan in rodent models, but the effects on metabolic health and function have widely debated both clinical translational trials. Prior rapamycin being used as a treatment healthspan human population, it is vital assess side of pathways animal model systems, including closely related non-human primate model. In this study, we found that long-term marmoset monkeys with orally-administered encapsulated resulted no overall body weight only small decrease fat...
Executive control is a higher‐level cognitive function that involves range of different processes are involved in the planning, coordination, execution, and inhibition responses. Many associated with executive control, such as response mental flexibility, decline age. Degeneration white matter architecture considered to be one key factors underlying aging. Here we investigated how changes corpus callosum were related aging common marmosets ( Callithrix jacchus ). We hypothesized reduction...
Abstract The gut microbiome is known to play a significant role in human health but its aging remains unclear. objective of this study was compare the composition between young adult and geriatric non‐human primates (marmosets) as model disease. Stool samples were collected from (8+ years) males (2–5 years). 16S ribosomal RNA V4 sequences amplified sequenced on Illumina MiSeq platform. Sequences clustered into operational taxonomic units classified via Mothur's Bayesian classifier referenced...
Summary There are no known cures or vaccines for COVID-19, the defining pandemic of this era. Animal models essential to fast track new interventions and nonhuman primate (NHP) other infectious diseases have proven extremely valuable. Here we compare SARS-CoV-2 infection in three species experimentally infected NHPs (rhesus macaques, baboons, marmosets). During first 3 days, macaques developed clinical signatures viral systemic inflammation, coupled with early evidence replication...
Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth defects. The utmost goal of ZIKV vaccines to prevent both maternal-fetal infection and syndrome. A purified inactivated (ZPIV) was previously shown be protective in non-pregnant mice rhesus macaques. In this study, we further examined the efficacy ZPIV against during pregnancy immunocompetent C57BL6 common marmoset monkeys (Callithrix jacchus). We showed that, C57BL/6 mice, significantly reduced...
We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-β on neopterin β<sub>2</sub>-microglobulin blood levels. All NAB-negative patients had an (full or partial), whereas all high-level positive no response. High-level NAB more MRI activity than (<i>p</i> = 0.031). Patients with a full less without 0.032).
Abstract We provide here a current overview of marmoset (Callithrix) evolution, hybridization, species biology, basic/biomedical research, and conservation initiatives. Composed 2 subgroups, the aurita group (C C flaviceps) jacchus geoffroyi, jacchus, kuhlii, penicillata), this relatively young primate radiation is endemic to Brazilian Cerrado, Caatinga, Atlantic Forest biomes. Significant impacts on Callithrix within these biomes resulting from anthropogenic activity include (1) population...