Amanda Mannino
A5007737959- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Respiratory viral infections research
- Herpesvirus Infections and Treatments
- Virology and Viral Diseases
Texas Biomedical Research Institute
2020-2024
Summary There are no known cures or vaccines for COVID-19, the defining pandemic of this era. Animal models essential to fast track new interventions and nonhuman primate (NHP) other infectious diseases have proven extremely valuable. Here we compare SARS-CoV-2 infection in three species experimentally infected NHPs (rhesus macaques, baboons, marmosets). During first 3 days, macaques developed clinical signatures viral systemic inflammation, coupled with early evidence replication...
While simian immunodeficiency virus (SIV) infection is non-pathogenic in naturally infected African nonhuman primate hosts, experimental or accidental rhesus macaques often leads to AIDS. Baboons, widely distributed throughout Africa, do not harbor SIV, and of baboons with SIVmac results transient low-level viral replication. Elucidation mechanisms natural immunity could uncover new targets antiviral intervention. We tested the hypothesis that an adapted replicate baboon primary cells will...