A5019468970- Multiple Sclerosis Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Systemic Lupus Erythematosus Research
- Optical Imaging and Spectroscopy Techniques
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Cardiac and Coronary Surgery Techniques
- Polyomavirus and related diseases
- Long-Term Effects of COVID-19
- Ocular Diseases and Behçet’s Syndrome
- Systemic Sclerosis and Related Diseases
- Cerebrovascular and Carotid Artery Diseases
- Photoacoustic and Ultrasonic Imaging
- Mitochondrial Function and Pathology
- Rheumatoid Arthritis Research and Therapies
- Immunotherapy and Immune Responses
- Traumatic Brain Injury and Neurovascular Disturbances
- Functional Brain Connectivity Studies
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Anesthesia and Neurotoxicity Research
- Infrared Thermography in Medicine
- Childhood Cancer Survivors' Quality of Life
- Retinal and Optic Conditions
Rigshospitalet
2012-2024
University of Copenhagen
2006-2023
Copenhagen University Hospital
2006-2023
Capital Region of Denmark
2002-2012
Glostrup Hospital
2005-2010
Hvidovre Hospital
2000-2010
Statens Serum Institut
2005
Background: Cerebral injury is an important complication after cardiac surgery with the use of cardiopulmonary bypass. The rate overt stroke 1% to 2%, whereas silent strokes, detected by diffusion-weighted magnetic resonance imaging, are found in up 50% patients. It unclear whether a higher versus lower blood pressure during bypass reduces cerebral infarction these Methods: In patient- and assessor-blinded randomized trial, we allocated patients (70–80 mm Hg) or (40–50 target for mean...
<h3>Background</h3> A diagnosis of multiple sclerosis in patients who present for the first time with a clinically isolated syndrome (CIS) can be established brain magnetic resonance imaging (MRI) if MRI demonstrates demyelinating lesions dissemination space (DIS) and (DIT). <h3>Objective</h3> To investigate diagnostic performance single study obtained within 3 months after symptom onset cohort CIS suggestive at presentation. <h3>Design</h3> Multicenter inception follow-up least 24 months....
To systematically describe central (CNS) and peripheral (PNS) nervous system complications in hospitalized COVID-19 patients.We conducted a prospective, consecutive, observational study of adult patients from tertiary referral center with confirmed COVID-19. All were screened daily for neurological neuropsychiatric symptoms during admission discharge. Three-month follow-up data collected using electronic health records. We classified as caused by SARS-CoV-2 neurotropism, immune-mediated or...
Multiple sclerosis (MS) is a chronic immune-mediated disease characterized by demyelination and neuroaxonal damage in the central nervous system. The etiology complex still not fully understood. Accumulating evidence suggests that our gut microbiota its metabolites influence MS pathogenesis. Short-chain fatty acids (SCFAs), such as acetate, propionate butyrate, are produced through fermentation of indigestible carbohydrates. SCFAs kynurenine have been shown to important immunomodulatory...
<b>Objective:</b> To investigate if IV immunoglobulin (IVIG) treatment in the acute phase of optic neuritis (ON) could improve visual outcome and reduce MRI disease activity 6 months after onset ON. <b>Methods:</b> Sixty-eight patients with ON were randomized within 4 weeks from symptoms. Thirty-four to IVIG 0.4 g/kg body wt, 34 placebo. Infusions given at days 0, 1, 2, 30, 60. Contrast sensitivity, acuity, color vision measured baseline 1 week, month, months. Pattern reversal evoked...
<h3>Background:</h3> Enlarged ventricles and reduced hippocampal volume are consistently found in patients with first-episode schizophrenia. Studies investigating brain structure antipsychotic-naive have generally focused on the striatum. In this study, we examined whether ventricular enlargement caudate reductions morphological traits of <h3>Methods:</h3> We obtained high-resolution 3-dimensional <i>T</i><sub>1</sub>-weighted magnetic resonance imaging scans for 38 schizophrenia 43 matched...
We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-β on neopterin β<sub>2</sub>-microglobulin blood levels. All NAB-negative patients had an (full or partial), whereas all high-level positive no response. High-level NAB more MRI activity than (<i>p</i> = 0.031). Patients with a full less without 0.032).
Debilitating brain injury occurs in 1.6-5 % of patients undergoing cardiac surgery with cardiopulmonary bypass. Diffusion-weighted magnetic resonance imaging studies have reported stroke-like lesions up to 51 after surgery. The majority the seem be caused by emboli, but inadequate blood flow other mechanisms may increase ischaemia penumbra or cause watershed infarcts. During bypass, pressure can below lower limit cerebral autoregulation. Although much debated, constant provided bypass system...
The volume of cortical activation as detected by functional magnetic resonance imaging (fMRI) in the visual cortex has previously been shown to be reduced following optic neuritis (ON). In order understand cause this change, we studied activation, both size activated area and signal change ON, compared results with neuroophthalmological testing. We nine patients previous acute ON 10 healthy persons served controls using fMRI stimulation. addition a volume, showed blood oxygenation level...
Disease activity is highly variable in patients with multiple sclerosis (MS), both untreated and during interferon (IFN)-beta therapy. Breakthrough disease often regarded as treatment failure; however, apart from neutralizing antibodies (NAbs), no blood biomarkers have been established reliable indicators of response, despite substantial, biologically measurable effects. We studied the biologic response to a cohort NAb-negative test whether difference responsiveness could segregate without...
Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, cognitive impairment by overlapping mechanisms. The purpose this study was to test hypothesis that caloric (ADCR) with overall energy balance would reduce resistance accumulation fat, in addition improving functions, after 8 consecutive days bed. Healthy, lean men (n = 20) were randomized 1) bed rest three daily...
Abstract OBJECTIVES Cardiac surgery is associated with risk of cerebral injury and mean arterial pressure (MAP) during cardiopulmonary bypass (CPB) suggested to be injury. The ‘Perfusion Pressure Cerebral Infarcts’ (PPCI) trial randomized patients undergoing coronary artery grafting (CABG) and/or aortic valve replacement a MAP 40–50 or 70–80 mmHg CPB found no difference in clinical imaging outcomes between the groups. We here present PPCI predefined secondary end points, consisting...
Although treatment of multiple sclerosis (MS) with the type I interferon (IFN) IFN-β lowers disease activity, role endogenous IFN in MS remains controversial. We studied CD4+ T cells and cell subsets, monocytes dendritic by flow cytometry analysed relationship IFN-like effect therapy, clinical magnetic resonance imaging (MRI) activity patients. Endogenous was associated decreased expression integrin subunit CD49d (VLA-4) on CD4+CD26high (Th1 helper cells), this less MRI activity. therapy...
Abstract Objective To systematically describe CNS and PNS complications in hospitalized COVID-19 patients. Methods We conducted a prospective, consecutive, observational study of adult patients from tertiary referral center with confirmed COVID-19. All were screened daily for neurological neuropsychiatric symptoms during admission, at discharge 3-month follow-up. classified as caused by SARS-CoV-2 neurotropism, immune-mediated or critical illness-related. Results From April-September 2020,...
Background Brain injury and cognitive dysfunction are serious complications after cardiac surgery. In the perfusion pressure cerebral infarcts (PPCI) trial, we allocated surgery patients to a mean arterial of either 70‐80 mm Hg (high‐target) or 40‐50 (low‐target) during cardiopulmonary bypass. this secondary analysis, aimed assess potential differences in domain‐specific patterns deterioration between allocation groups investigate any associations postoperative (POCD) with diffusion‐weighted...