Efficacy and tolerability of the new antiepileptic drug oxcarbazepine, was evaluated in a retrospective multicentre study. The records all 947 epilepsy patients treated with oxcarbazepine eight participating centres from 1981 through 1990 were examined. median daily dose 30 mg/kg children, 18 adults, 15 elderly patients, given b.i.d. or t.i.d. mean plasma levels main active metabolite 88, 79, 68 mumol/l elderly, respectively. In shifted to treatment, seizure frequency unchanged 51-66%,...

DNA-encoded small molecule libraries (DELs) have facilitated the discovery of novel modulators many different therapeutic protein targets. We report first successful screening a multimillion membered DEL inside living cell. demonstrate method using oocytes from South African clawed frog Xenopus laevis. The large size 1 μL, or 100 000 times bigger than normal somatic cell, permits simple injection DELs, thus resolving fundamental problem delivering DELs across cell membranes for in vivo...

Limited solubility and precipitation of amyloidogenic sequences such as the Alzheimer peptide (β-AP) are major obstacles to a molecular understanding protein fibrillation deposition processes. Here we have circumvented problem by stepwise engineering β-AP homology into soluble scaffold, monomeric S6. The S6 construct with highest crystallizes tetramer that is linked residues forming intermolecular antiparallel β-sheets. This also shows increased coil aggregation during refolding, 14-mer...

The interpretation of folding rates is often rationalized within the context transition state theory. This means that reaction rate linked to an activation barrier, height which determined by free energy difference between a ground (the starting point) and apparent state. Changes in kinetics are thus caused effects on either state, or both. However, structural changes rarely discussed connection with experimental data, kinetic anomalies commonly ascribed alone, e.g., depletion accumulation...

In a controlled investigation the clinical findings in 96 patients with paranoid/hallucinatory psychosis and partial epileptic seizures complex symptoms, were compared control same type of epilepsy without median 24 years' duration. The age at onset was 34 years, after 21 seizure frequency complex, significantly lower psychotic group, while generalized did not differ. A significant preponderance group left-handed patients, etiological factors neurological signs reflecting organic damage,...

The EEG findings in waking, sleep, and sphenoidal electrode recordings 96 patients with partial epileptic seizures complex symptoms, who, after a median interval of 18 years developed paranoid/hallucinatory psychosis, were compared the from group without who had same type epilepsy 24 years. There no significant differences between two groups regard to age at onset or seizures, age, duration time examination. psychotic preponderance temporal medio-basal spike foci, recorded on electrode,...

To investigate whether the efficacy of interferon-beta (IFNbeta) treatment relapsing-remitting MS (RR-MS) was influenced by type, dose, and frequency administration.From June 1996 through October 1997, authors offered participation to all Danish RR-MS patients who met following criteria: definite MS, at least two relapses within 2 years, age 18 55, an Expanded Disability Status Scale (EDSS) score < or = 5.5. The study multicenter, controlled, open-label, randomized, head-to-head comparing...

Patients with unilateral temporal lateral or mediobasal epileptic focus as ascertained by sphenoidal electrode EEG recordings were evaluated using the questionnaire designed Bear & Fedio (1977). The seventeen traits defined items in this also assessed close observers an equivalent questionnaire. medio-basal lobe found generally to exhibit "epileptic" personality a greater extent than patients focus, and results indicated that they also, more characterized schizoid paranoid outlook. left be...

Ras GTPase Activating Protein SH3 Domain Binding (G3BP) is a potential anti-cancer drug target implicated in several cellular functions. We have used protein crystallography to solve crystal structures of the human G3BP1 NTF2-like domain both alone and complex with an FxFG Nup repeat peptide. Despite high structural similarity, binding site located between two alpha helices not at dimer interface as observed for nuclear transport factor 2. ITC studies showed specificity towards motif but FG...

Cessation of smoking is widely recommended in patients with stroke to reduce the risk myocardial infarction and recurrent stroke, but little known regarding how modify their habits after a stroke. We used data from prospective follow-up study assess modification identify predictors persistent first-ever stroke.All admitted only neurology department Funen County (465 000 inhabitants) August 1, 1999, January 31, 2001, were prospectively identified. A comprehensive structured interview was...

The effect of indomethacin 25 mg 3 times daily during the first 2 postoperative weeks in preventing heterotopic bone formation after cemented total hip arthroplasty was investigated a randomized, double-blind and placebo-controlled clinical trial on 57 patients. 16 patients were secondarily excluded, leaving 19 group 22 placebo group. Evaluated from 3-month radiographs, 18/19 developed either no or only milder Grade 1 ossification. In contrast, 11/22 ossifications. Our observations favor...

Abstract Allergy to house dust mite is among the most prevalent allergic diseases worldwide. Most patients react Der p 1 from Dermatophagoides pteronyssinus, which a cysteine protease. To avoid heterogeneity in sample used for crystallization, modified recombinant molecule was produced. The sequence of proDer allergen reduce glycosylation and abolish enzymatic activity. resulting rproDer preparation homogenous stable yielded crystals diffracting resolution 1.61 Å. active site located large...

We have reviewed at an average period of ten years the results 71 consecutive primary arthroplasties with Insall-Burstein total condylar knee prosthesis in patients rheumatoid arthritis. Their mean age surgery was 52 (24 to 72). At follow-up overall (Hospital for Special Surgery rating score) were excellent or good 77%, fair 11% and poor 11%. There residual pain only 5% prostheses situ; 58% could walk more than 500 m, median range motion 108 degrees. Eight knees had been revised. Five...

After administration of 600 mg the antiepileptic oxcarbazepine to 7 healthy volunteers, serum and stimulated saliva samples were collected for next 72 h. Concentrations 10-OH-carbazepine, main metabolite oxcarbazepine, determined by an HPLC method. The time-concentration curves showed a median Tmax 8 h followed plateau until 24 indicating saturable kinetic processes. Based on curves, pharmacokinetic parameters calculated. half-life 10-OH-carbazepine in saliva, 13.8 +/- 3.7 (SD) h, was...

Risk factors and prognosis for pseudoseizures were studied in a matched pairs case-control investigation of Epilepsy Clinic out-patients. The case group comprised 28 patients with pseudoseizures, 4 whom without prior diagnosis epilepsy. control consisted age- sex-matched epileptic patients. There was marked female preponderance, 86%, the pseudoseizures. frequency previous psychiatric problems significantly higher case- than group, while major cerebral damage idiopathic generalized epilepsy...

Abstract Background: Increased concentrations of both plasma total homocysteine and copper are separately associated with cardiovascular disease. Correlations between homocysteine, trace elements, vitamins in patients peripheral vascular disease have not been investigated. Methods: The elements were determined by the multielement analytical technique total-reflection x-ray fluorescence spectrometry. Plasma was HPLC. Results: In univariate multivariate regression analyses, positively...

In a controlled investigation of paranoid hallucinatory chronic or episodic epileptic psychoses, the social data, psychopathological symptoms and psychological test findings (WAIS, Rorschach, object-sorting, proverb-interpretation Stroop test) were analyzed in order to delineate characteristics psychotic syndrome evaluate significance organic etiological factors. The study comprised 45 patients with complex partial epilepsy followed by psychosis after median 23 years, 34 control same type 30...

Endoscopic retrograde brush cytology (ERBC) was performed in 29 patients with primary pancreatic malignancies verified later by histology. Results were positive 21 patients, suspicious five, and negative three. ERBC seven uncertain findings at endoscopic cholangiopancreatography (ERCP) for malignancy six one. aspiration (EAC) 10 tumours three, two, five cases. and/or EAC cases secondary one four. It is concluded that gives a high rate of or (90%) diagnosis lesions. In seems to be most The...

Interobserver variation among four observers in evaluation of eight selected neurological signs was investigated. MATERIAL & METHODS--Two hundred and two consecutive unselected inpatients were examined by senior neurologists trainees, all without knowledge the case history. The were: anisocoria, jerky eye movements, facial palsy, elbow extension force, finger-nose test, Barré sign, knee jerk, extensor plantar reflex. Observed agreement rates kappa coefficients calculated order to compare...