A5068906584- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Cardiac tumors and thrombi
- Lymphoma Diagnosis and Treatment
- Anesthesia and Pain Management
- Bone health and treatments
- Inflammatory mediators and NSAID effects
- Soft tissue tumor case studies
- Colorectal and Anal Carcinomas
- Soft tissue tumors and treatment
- Bone fractures and treatments
- Musculoskeletal synovial abnormalities and treatments
- Oral and Maxillofacial Pathology
- Knee injuries and reconstruction techniques
- Cancer, Hypoxia, and Metabolism
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Veterinary Pharmacology and Anesthesia
- Shoulder Injury and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Vascular Malformations and Hemangiomas
Saarland University
2024
Aarhus University Hospital
2011-2022
Erasmus MC Cancer Institute
2020
Sarcoma Oncology Center
2014
Marymount University
2006
Aarhus University
1991-2003
Aarhus Municipality
1992-2002
Regional Hospital Randers
1998
Odense University Hospital
1995
Rigshospitalet
1995
Hyperactivity of N-methyl d-aspartate (NMDA) receptors may be one the factors in maintenance persistent stump and phantom limb pain. Ketamine (bolus at 0.1 mg/kg/5 min followed by an infusion 7 μg/kg/min) was administered intravenously to 11 patients with established pain a double-blind saline-controlled study. All responded decrease rating assessed visual analogue scale (VAS) McGill Pain Questionnaire (MPQ). increased pressure-pain thresholds significantly. Wind-up-like (pain evoked...
Clinical and experimental studies have suggested that tumour hypoxia is associated with poor treatment outcome loss of apoptotic potential may play a role in malignant progression neoplastic cells. The suppressor gene p53 induces apoptosis under certain conditions microenvironmental select for mutant cells diminished due to lack function. aim this study was evaluate the prognostic relevance oxygenation status compare pre-treatment measurements were done 31 those by PCR using DNA extracted...
AbstractThe ability of exogenous Transforming Growth Factor-β (TGF-β) to stimulate bone formation in fracture healing was investigated. TGF-β continuously applied doses 1 and 10 μg/day for 6 weeks 2 groups adult rabbits with unilateral plated midtibial osteotomies. A group receiving solvent without served as control. Fracture evaluated by mechanical tests, morphometry densitometry. Increased maximal bending strength callus were demonstrated the TGF-β. had no effect on bending-stiffness,...
Pain after amputation is common but difficult to treat. Therefore, the authors examined whether postoperative treatment with gabapentin could reduce postamputation stump and phantom pain.Forty-six patients scheduled undergo lower limb were randomly assigned receive oral or placebo. Treatment was started on first day continued for 30 days. The daily dose of placebo gradually increased 2,400 mg/day. intensity pain recorded every a numeric rating scale (0-10) during 30-day period. Five...
In metastatic disease, decisions regarding potential surgery require reliable data about the patient's survival. this study, we evaluated different prognostic factors and their impact in four common primary tumors causing bone metastases.Data were acquired from Scandinavian Sarcoma Group (SSG) metastasis registry. The patients underwent between July 1999 2009. This study included breast, prostate, lung, kidney cancer cases, with a total of 672 operated non-spinal metastases. Differences...
A follow-up investigation of 25 cases extraskeletal osteosarcomas diagnosed at the Center for Bone and Soft Tissue Tumors, Aarhus University Hospital, Denmark, in period from 1970-1995 was undertaken. The immunohistochemical profile these tumors evaluated using a panel 10 antibodies, value alkaline phosphatase staining differential diagnostic situations also considered. study revealed that this tumor is high-grade malignant affects adults (median age, 67 years; range, 35-82 years) diagnosis....
The assessment of the prognosis for individual patient is important choice surgical treatment skeletal metastases. In 1999 Scandinavian Sarcoma Group (SSG) initiated Skeletal Metastasis Register as a multicentric, prospective study to provide scientific basis recommendations. To improve prognostication we analyzed survival patients with metastases surgically treated at 9 SSG centres.460 an average age 64 years underwent 501 operations non-spinal 7% were operated more than one metastasis....
Superficial leiomyosarcomas are rare tumours. The lesions confined to the dermis, contrary those involving subcutis, have been reported carry a favourable prognosis. A retrospective study of 41 consecutive cases surgically treated intradermal and subcutaneous was undertaken in order determine prognostic factors that may influence survival these patients. Seven tumours were predominantly 34 involved tissue. Fifty‐four percent located lower extremities. All stained positively for smooth muscle...
We measured mineral content, maximum bending strength, and regional blood flow after tibial osteotomy fixed with a small metal plate in 38 rabbits. Half of the animals were treated indomethacin (10 mg/kg/day) while other half served as controls.After 2 6 weeks, bone content strength lower group when compared controls. Compared controls, at site was decreased weeks increased indomethacin-treated animals.Inhibition increase by medication early period following osteotomy, well retarded healing,...
Aim. The aim of this study was to assess the incidence low-grade fibromyxoid sarcoma (LGFMS), present treatment results metastatic LGFMS, and investigate clinical significance FUS gene rearrangement. Methods. This included 14 consecutive LGFMS patients treated at Aarhus Sarcoma Centre in 1979-2010. Fluorescent situ hybridization (FISH) analysis for break-apart performed all patients. Results. 0.18 per million, representing 0.6% soft tissue sarcomas. Four needed multiple biopsies/resections...
Background and purpose — Previous studies of soft tissue sarcoma (STS) have identified a number possible prognostic factors; however, the majority these include highly selected populations, with unclear validation data insufficient statistical methods. We factors in validated, population-based 30-year series STS treated at single institution, using an advanced approach. Patients methods Between 1979 2008, 922 adult patients from western Denmark were Aarhus Sarcoma Center for non-metastatic...
We evaluated prognostic factors for local recurrence-free survival, including expression of estrogen receptors, after surgical treatment aggressive fibromatosis in 72 patients (53 women) having primary tumors between 1970 and 1998. Their median age at diagnosis was 31 (1 month-77 years) years. 50 had extraabdominal 22 abdominal fibromatosis. Median tumor size 4 (1-27) cm. 8 were treated with an intralesional resection, 32 marginal, wide 1 radical resection. They followed a The overall 5-year...
The effect of indomethacin 25 mg 3 times daily during the first 2 postoperative weeks in preventing heterotopic bone formation after cemented total hip arthroplasty was investigated a randomized, double-blind and placebo-controlled clinical trial on 57 patients. 16 patients were secondarily excluded, leaving 19 group 22 placebo group. Evaluated from 3-month radiographs, 18/19 developed either no or only milder Grade 1 ossification. In contrast, 11/22 ossifications. Our observations favor...
We recently developed two Bayesian networks, referred to as the Bayesian-Estimated Tools for Survival (BETS) models, capable of estimating likelihood survival at 3 and 12 months following surgery patients with operable skeletal metastases (BETS-3 BETS-12, respectively). In this study, we attempted externally validate BETS-3 BETS-12 models using an independent, international dataset. Data were collected from Scandinavian Skeletal Metastasis Registry extremity surgically treated eight major...
There is increasing interest in personalized prediction of disease progression for soft tissue sarcoma patients. Currently, available models are limited to predictions from time surgery or diagnosis. This study updates overall survival at different times during follow-up by using the concept dynamic prediction. Information 2232 patients with high-grade extremity sarcoma, who underwent 14 specialized centers, was used develop a model. The model provides updated 5-year probabilities points...
Standardized osteochondral fractures in the left femoral condyle 19 adult mongrel dogs were fixed with either fibrin sealant or Kirschner wire. Adaptation and mechanical strength after 4, 7 8, 14 days compared an vitro study of initial fractures. After 4 days, maximum tensile was increased sealed group, whereas no difference energy absorption at failure found. Although bond low, tendency to displacement less this group. Our results suggest that can be used for fixation small fragments,...
OBJECTIVE: Certain biomarkers such as the C-reactive protein, serum albumin, and neutrophils to lymphocyte ratio are of prognostic significance regarding survival in different types cancers. Data from sarcoma patients sparse mainly derived soft tissue and/or metastatic cases. Adjusting for confounders comorbidity age is an essential safeguard against erroneous conclusions possible value these biomarkers. The aim this study was assess a battery pretreatment with localized bone sarcomas adjust...
We investigated the effect of local infusion with prostaglandin E2 (PGE2) in doses 0.0003 to 4.0 mg/hour per kg body weight for 6 weeks on a plated unilateral osteotomy rabbits. PGE2 caused dose-dependent stimulation callus formation. Total bone mineral content increased, although volume was reduced. In another experiment, infused either first half or second healing period. No could be observed 6-week period, whereas during stimulation.