A5032382366- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Lymphoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Colorectal and Anal Carcinomas
- Advanced Chemical Sensor Technologies
- Sulfur Compounds in Biology
- Amino Acid Enzymes and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Advanced Glycation End Products research
- Foot and Ankle Surgery
- Insect Pheromone Research and Control
- Genetic and Kidney Cyst Diseases
- Polydiacetylene-based materials and applications
- Molecular Biology Techniques and Applications
- Reconstructive Surgery and Microvascular Techniques
- Gas Sensing Nanomaterials and Sensors
- Cancer Genomics and Diagnostics
- Biomedical Research and Pathophysiology
- Antimicrobial Peptides and Activities
- Lower Extremity Biomechanics and Pathologies
Leiden University Medical Center
2018-2024
Leiden University
2017-2023
Erasmus MC Cancer Institute
2020-2021
University Medical Center Groningen
2013-2018
Hospital for Sick Children
2018
University of Groningen
2014
There are few studies detailing the incidence, patient outcomes and prognostic factors for chondrosarcomas (CS). Those that do exist have small sample sizes and/or use older datasets. The purpose of this study was to determine overall survival (OS) OS CS patients, as well investigate efficacy curettage.We analyzed data 2186 patients diagnosed with between '89-'13 from Netherlands Cancer Registry. effect risk on assessed a multivariate Cox regression. Median Follow-up determined reversed...
Prognostic nomograms for patients with extremity soft tissue sarcoma (eSTS) typically predict survival or the occurrence of local recurrence distant metastasis at time surgery. Our aim was to develop and externally validate a dynamic prognostic nomogram overall in eSTS survivors use during follow-up.All primary operated curative intent between 1994 2013 three European one Canadian centers formed development cohort. Patients Fédération Française des Centres de Lutte Contre le Cancer (FNCLCC)...
Diabetes and particularly high blood glucose levels are implicated in neurodegeneration. One of the hallmarks neurodegeneration is protein aggregation. We investigated presence aggregation frontal brain Zucker diabetic fatty (ZDF) rats, an animal model for diabetes. Further, effect NaHS suppressing cultured slices from ZDF was assessed.The synthesis, protein/gene expression, autophagy anti-oxidant defense were evaluated control (Lean) brains.Compared to Lean, brains displayed a significant...
There is increasing interest in personalized prediction of disease progression for soft tissue sarcoma patients. Currently, available models are limited to predictions from time surgery or diagnosis. This study updates overall survival at different times during follow-up by using the concept dynamic prediction. Information 2232 patients with high-grade extremity sarcoma, who underwent 14 specialized centers, was used develop a model. The model provides updated 5-year probabilities points...
Up to 40% of patients with idiopathic clubfoot who are treated the Ponseti method experience recurrence deformity. Many these receive surgery (e.g., anterior tibial tendon transfer). An alternative approach for recurrent is repeat casting. The purpose this study was evaluate outcome casting in treatment clubfoot.Patients were at our hospital, between 2004 and 2012, serial bracing (the group) eligible inclusion study. group a control randomly selected seen during same period had not compared...
The aim of the study is to assess effect perioperative chemotherapy (CTX) in patients with grade II-III extremity soft tissue sarcoma (eSTS) on overall survival (OS) and evaluate whether PERSARC prediction tool could identify eSTS more likely benefit from CTX.Patients (18-70 years) primary high-grade surgically treated curative intent were included retrospective cohort study. any CTX anthracycline + ifosfamide (AI)-based OS was investigated three PERSARC-risk groups (high/intermediate/low)....
Abstract Background and Objectives A dynamic prediction model for patients with soft tissue sarcoma of the extremities was previously developed to predict updated overall survival probabilities throughout patient follow‐up. This study updates externally validates model. Methods Data from 3826 high‐grade extremity sarcoma, treated surgically curative intent were used update PERsonalised SARcoma Care (PERSARC) Patients added development cohort grade included in External validation performed...
Currently, patients with extremity soft tissue sarcoma (eSTS) who have undergone curative resection are followed up by a heuristic approach, not covering individual patient risks. The aim of this study was to develop two flexible parametric competing risk regression models (FPCRRMs) for local recurrence (LR) and distant metastasis (DM), aiming at providing guidance on how individually follow-up patients. Three thousand sixteen (1931 test, 1085 validation cohort) high-grade eSTS were included...
No studies extensively compared the young adults (YA, 18-39 years), middle-aged (40-69 and elderly (≥70 years) population with primary high-grade extremity soft tissue sarcoma (eSTS). This study aimed to determine whether known effect of age on overall survival (OS) disease progression can be explained by differences in tumour characteristics treatment protocol among YA, patients eSTS treated curative intent.In this retrospective multicentre study, inclusion criteria were 18 years older,...
Our aim was to develop and validate nomograms that would predict the cumulative incidence of sarcoma-specific death (CISSD) disease progression (CIDP) in patients with localized high-grade primary central dedifferentiated chondrosarcoma.The study population consisted 391 from two international sarcoma centres (development cohort) who had undergone definitive surgery for a (histological grade II or III) conventional chondrosarcoma chondrosarcoma. Disease captured first event either metastasis...
Aim of this explorative pilot study was to evaluate the capability an electronic nose (aeoNose, eNose Company) classify healthy individuals and patients with chondrosarcoma, based on their volatile organic compound profiles in exhaled breath.
Patients with locally extensive high-grade extremity soft tissue sarcomas (eSTS) are often presented in multidisciplinary teams to decide between ablative surgery (amputation) or limb-salvage supplemented either neo-adjuvant radiotherapy (RT) induction isolated limb perfusion (ILP). In The Netherlands, ILP typically aims reduce the size of tumors that would otherwise be considered irresectable, whereas RT mainly at improving local control and reducing morbidity required marginal margins....
Abdominal metastases (AM) from soft tissue sarcoma (STS) are rare and prognosis is poor. The aims of the study were to (a) identify risk factors for development AM (b) investigate outcome AM-patients.
With soft-tissue sarcoma of the extremity (ESTS) representing a heterogenous group tumors, management decisions are often made in multidisciplinary team (MDT) meetings. To optimize outcome, nomograms more commonly used to guide individualized treatment decision making.To evaluate influence Personalised Sarcoma Care (PERSARC) on for patients with high-grade ESTS and ability MDT accurately predict overall survival (OS) local recurrence (LR) rates.Two consecutive meetings were organised. During...
This subgroup analysis of undifferentiated pleomorphic soft tissue sarcoma the extremity (eUPS) from PERSARC collaborative group aimed to achieve a more personalized multimodality treatment approach for primary eUPS in elderly patients.A multicenter retrospective study including high-grade surgically treated with curative intent between 2000 and 2016. Overall survival (OS), local recurrence (LR) distant metastasis (DM) curves were calculated by Kaplan Meier analysis. Cox proportional hazard...
Due to the relatively advanced age and high mortality rate of patients with high-grade chondrosarcoma (CS), it is important holistically assess patient- tumor characteristics in multidisciplinary team shared decision-making regard treatment options. While current prognostic models include multiple characteristics, only patient that are commonly included gender. Based on clinical experience, we believe factors related preoperative systemic health status such as American Society...
Aim: This study was interested in extremity leiomyosarcoma with focus on clinical outcome after surgery or without adjuvant therapy. Patients and Methods: A retrospective case series of all patients leiomyosarcoma, surgically treated between 2000 2015 a minimum follow-up 2 years, drawn from institutional databases Belgium the Netherlands. Postoperative complications were reported Radiation Therapy Oncology Group (RTOG) Henderson classification. Results: Seventy-five operated on, whom 47...
The aim of this pilot study was to assess whether an electronic nose can detect patients with soft tissue sarcoma (STS) based on volatile organic compound profiles in exhaled breath.