A5054115574- Sarcoma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Vascular Tumors and Angiosarcomas
- Cancer Immunotherapy and Biomarkers
- Bone Tumor Diagnosis and Treatments
- Cardiac tumors and thrombi
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Effects of Radiation Exposure
- Colorectal and Anal Carcinomas
- Molecular Biology Techniques and Applications
- Tumors and Oncological Cases
- Oral and Maxillofacial Pathology
- CAR-T cell therapy research
- Management of metastatic bone disease
- Soft tissue tumor case studies
- Cancer, Lipids, and Metabolism
- Musculoskeletal synovial abnormalities and treatments
- Extracellular vesicles in disease
- Hematological disorders and diagnostics
Aarhus University Hospital
2015-2024
Aarhus University
2003-2024
Sarcoma Oncology Center
2014
Abstract Background Use of exosomes as biomarkers in non‐small cell lung cancer (NSCLC) is an intriguing approach the liquid‐biopsy era. Exosomes are nano‐sized vesicles with membrane‐bound proteins that reflect their originating cell. Prognostic needed to improve patient selection for optimal treatment. We here evaluate by protein phenotyping a prognostic biomarker NSCLC. Methods from plasma 276 NSCLC patients were phenotyped using Extracellular Vesicle Array; 49 antibodies captured on...
Background and purpose — Previous studies of soft tissue sarcoma (STS) have identified a number possible prognostic factors; however, the majority these include highly selected populations, with unclear validation data insufficient statistical methods. We factors in validated, population-based 30-year series STS treated at single institution, using an advanced approach. Patients methods Between 1979 2008, 922 adult patients from western Denmark were Aarhus Sarcoma Center for non-metastatic...
Inflammation-scores based on general inflammation markers are suggested as prognostic of overall survival (OS) in lung cancer. However, whether these inflammation-scores improves the prognostication performed by well-established is unsettled. In a large register-based cancer patient cohort, nine different were compared, and their ability to optimize OS was evaluated.Lung patients diagnosed from 2009-2018 The Central Denmark Region identified Danish Lung Cancer Registry. Pre-treatment...
The effect of chemotherapy in metastatic bone sarcomas is poor and the condition invariably fatal. Therefore, new treatment modalities are intensely needed. Pazopanib a selective multitargeted tyrosine kinase inhibitor that has proven to be effective soft tissue sarcomas. objective this study was evaluate off-label use pazopanib patients with who failed standard chemotherapy.All treated between October 1st, 2011 2017 at Department Oncology, Aarhus University Hospital were evaluated....
OBJECTIVE: Certain biomarkers such as the C-reactive protein, serum albumin, and neutrophils to lymphocyte ratio are of prognostic significance regarding survival in different types cancers. Data from sarcoma patients sparse mainly derived soft tissue and/or metastatic cases. Adjusting for confounders comorbidity age is an essential safeguard against erroneous conclusions possible value these biomarkers. The aim this study was assess a battery pretreatment with localized bone sarcomas adjust...
Checkpoint inhibitors have revolutionized the treatment of metastatic melanoma, yielding long-term survival in a considerable proportion patients. Yet, 40-60% patients do not achieve benefit from such therapy, emphasizing urgent need to identify biomarkers that can predict response immunotherapy and guide for best possible treatment. Here, we exploited an unsupervised machine learning approach potential inflammatory cytokine signatures liquid biopsies, which could melanoma.We studied cohort...
Background: The aim of the present study was to validate data in Aarhus Sarcoma Registry (ASR), determine if this registry is population-based for western Denmark, and examine incidence sarcomas using validated, data. Methods: This based on patients with bone soft tissue sarcoma treated at Centre University Hospital between January 1, 1979 December 31, 2008. validation process included a review all medical files by two researchers standardized form. Danish Cancer used as reference assess...
The aim of this study was to contribute the collected knowledge prognostic factors in primary breast sarcomas (PBS) benefit possible future prospective studies and therapeutic guidelines.All patients with pathologically verified PBS period 1979-2014 were extracted from a hospital-based database at Aarhus University Hospital. All records reviewed for patient tumor characteristics. Primary endpoints overall survival, disease-free survival (DFS) disease-specific (DSS). Adjustments made age,...
Purpose: Checkpoint inhibitors have significantly improved treatment of metastatic melanoma. However, 40–60% patients do not respond to therapy, emphasizing the need for better predictive biomarkers response immune checkpoint inhibitors. Prorammed death-ligand 1(PD-L1) expression in tumor cells is currently used as a biomarker; however, it lacks specificity. Therefore, utmost importance identify other novel that can predict outcome. Experimental design: We studied small cohort 16 with...
Comorbidity is an important prognostic factor for survival in other cancers, but the importance soft tissue sarcoma has not yet been clarified. The aims of this study were to examine prevalence comorbidity patients, and estimate impact on overall disease-specific mortality.Overall, 1210 adult patients with extremities or trunk wall identified through Aarhus Sarcoma Registry, a validated population-based database. Information was obtained National Patient Charlson's score calculated each...
The prognostic value of serum biomarkers in soft tissue sarcoma (STS) is limited, and its clinical applicability compromised by a common inability to adjust for important confounders. aim this study was determine the pretreatment on disease-specific survival (DSS) adjusted confounders.The included 818 patients with localized STS. Pretreatment levels albumin, C-reactive protein, hemoglobin, neutrophils, lymphocytes were tested individually combined scores: neutrophil/lymphocyte ratio (NLR),...
Inflammation has been validated as a host-related prognostic marker in cancer. The Glasgow Prognostic score (GPS) and neutrophil-to-lymphocyte ratio (NLR) are suggested measures of inflammation. However, the allocation patients questioned. Hence, optimized inflammation-scores developed, such combined NLR GPS (CNG) system, Aarhus composite biomarker (ACBS). So far, these have not lung cancer patients. We evaluated if were markers inferior survival Furthermore, we tested which led to better...
Cancer-specific survival estimates rely on precise and correct data the cause of death; however, these can be difficult to acquire, particularly in elderly patients where comorbidity is common. Furthermore, while some deaths are directly related cancer, others more complex, with cancer merely contributing. Another, precise, method assess relative mortality, i.e., mortality compared general population. The aims this study were describe soft tissue sarcoma, compare cancer-specific mortality....
Abstract Background Paraganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery radiation therapy (RT) main treatment choices. We present an analysis outcome toxicity after RT from 13 institutions Rare Cancer Network. Methods Data were collected using a questionnaire concerning patients' characteristics, treatment, outcome. A total 81 patients with 82 HNPGL analyzed. Results The median follow‐up was 48 months (1‐456). Sixty‐two lesions treated conventional 20...
Treatment of high-grade osteosarcoma remains a major challenge in orthopedic oncology as no breakthrough overall survival has occurred the past 20 years. Due to rarity disease, comparing results single institution best standard practice needs establishment clinical databases. The aim this study was report cumulative 30-years' experience and assess incidence, prognostic factors using recently validated, hospital-based database, representing all citizens living western Denmark, Aarhus Sarcoma...