A5101616838- Effects of Radiation Exposure
- Shoulder Injury and Treatment
- Radiation Therapy and Dosimetry
- Knee injuries and reconstruction techniques
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Total Knee Arthroplasty Outcomes
- Adhesion, Friction, and Surface Interactions
- Shoulder and Clavicle Injuries
- Sports injuries and prevention
- Diabetes and associated disorders
- Heat shock proteins research
- Renal function and acid-base balance
- Elbow and Forearm Trauma Treatment
- Plant Genetic and Mutation Studies
- Lung Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- DNA Repair Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Ion Transport and Channel Regulation
- Nerve Injury and Rehabilitation
- Radiation Effects and Dosimetry
- Potassium and Related Disorders
- Cancer Immunotherapy and Biomarkers
Aarhus University Hospital
1984-2023
Aarhus University
2023
Aalborg University Hospital
2001
The aim of the present study was to examine RBE for early damage in an vivo mouse model, and effect increased linear energy transfer (LET) towards distal edge spread-out Bragg peak (SOBP).The lower part right hind limb CDF1 mice irradiated with single fractions either 6 MV photons, 240 kV photons or scanning beam protons graded doses were applied. For proton irradiation, leg placed middle a 30-mm SOBP, assess different positions, 4 mm intervals from SOBP behind dose fall-off. Irradiations...
Conventional X-ray radiotherapy induces a pro-inflammatory response mediated by altered expression of inflammation-regulating cytokines. Proton scanning and irradiation produce distinct changes to cytokine gene in vitro suggesting that proton beam therapy may induce an inflammatory dissimilar radiation. The purpose the present study was determine whether radiation conventional photon would differential regulation circulating cytokines vivo.Female CDF1 mice were irradiated locally at right...
Introduction: Proton beam therapy delivers a more conformal dose distribution than conventional radiotherapy, thus improving normal tissue sparring. Increasing linear energy transfer (LET) along the proton track increases relative biological effectiveness (RBE) near distal edge of Spread-out Bragg peak (SOBP). The severity side effects following photon radiotherapy vary considerably between patients.Aim: dual study aim was to identify gene expression patterns specific radiation type and...
To examine the risk of 30-day postoperative mortality from transurethral resection prostate (TURP) in patients with liver cirrhosis, who are reportedly at considerably increased perioperative risk.For period 1 January 1977 to 31 December 1993, a population-based cohort was identified comprising Danish diagnosed cirrhosis and random sample Danes also undergoing TURP. Logistic regression models were used estimate association between age, type admission, comorbidity mortality.In 23 133 30...
Introduction: Normal tissue morbidity sets the dose limit for radiotherapy (RT) in cancer treatment and has importance quality of life survivors. A previous study prostate patients treated with RT generated clinical data radiation-induced measured by anorectal physiological methods validated questionnaires. Other studies have identified genetic predictors associated late outcome. We expanded biobank material aiming to validate single nucleotide polymorphisms (SNPs) a gene expression...
The transcriptional response of cells exposed to proton radiation is not equivalent the induced by traditional photon beams. Changes in cellular signalling most commonly studied using method Quantitative polymerase chain reaction (qPCR). Stable reference genes must be used accurately quantify target transcript expression. study aim was identify suitable for normalisation gene expression levels normal dermal fibroblasts irradiated with either or online tool RefFinder analyse and stably...
The benefit of combining immunotherapy with photon irradiation has been shown pre-clinically and clinically. This current pre-clinical study was designed to investigate the anti-tumour action protons.Male CDF1 mice, a C3H mammary carcinoma inoculated on right rear foot, were locally irradiated single radiation doses when tumours reached 200mm3. Radiation delivered an 83-107MeV pencil scanning proton beam in centre 3 cm spread out Bragg peak. Following (day 0), mice injected intraperitoneal...
This pre-clinical study was designed to refine a dissection method for validating the use of 15-gene hypoxia classifier, which previously established head and neck squamous cell carcinoma (HNSCC) patients, identify in prostate cancer. PC3 DU-145 adenocarcinoma cells, vitro, were gassed with various oxygen concentrations (0-21%) 24 h, followed by real-time PCR. Xenografts vivo, mice injected hypoxic markers [18F]-FAZA pimonidazole. Subsequently, tumors excised, frozen, cryo-sectioned,...
Abstract Background and Aims Mineralocorticoid receptor antagonists (MRA) reduce blood pressure, albuminuria the rate of disease progression in patients with chronic kidney (CKD) albuminuria. Despite these apparent benefits, only a very small fraction CKD are treated an MRA. This may part be due to fear hyperkalemia (HK), which most severe cases can cause life-threatening arrythmias. Indeed, international guidelines previous studies have excluded believed at high risk HK from treatment MRA...