A5038413672- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Angiogenesis and VEGF in Cancer
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Point processes and geometric inequalities
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Breast Lesions and Carcinomas
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Sarcoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Gastric Cancer Management and Outcomes
- Vascular Tumors and Angiosarcomas
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Molecular Biology Techniques and Applications
- Breast Implant and Reconstruction
University of Copenhagen
1986-2025
Aarhus University Hospital
2006-2024
Odense University Hospital
1996-2023
Vejle Sygehus
2011-2020
Lillebaelt Hospital
1995-2019
University of Southern Denmark
2011-2018
Aarhus University
1990-2018
Clinical Research Management
2016
Region of Southern Denmark
2015
Herlev Hospital
1986-2008
To examine the importance of estrogen receptor (ER), progesterone (PgR), human epidermal growth factor 2 (HER-2), and constructed subtypes in a large study randomly assigning patients to receive or not postmastectomy radiotherapy (PMRT).The present analysis included 1,000 3,083 high-risk breast cancer assigned PMRT Danish Breast Cancer Cooperative Group (DBCG) protocol 82 trials b c. Tissue microarray sections were stained for ER, PgR, HER-2. Median follow-up time alive was 17 years. End...
The glucagon‐like peptide‐1 receptor (GLP‐1R) plays an important role in regulating insulin secretion and reducing body weight, making it a prominent target the treatment of type 2 diabetes obesity. Extensive research on GLP‐1R signaling has provided insights into connection between function physiological outcomes, such as correlation Gs secretion, yet exact mechanisms remain unclear. Here, we explore internalization pathway GLP‐1R, which is crucial for controlling release maintaining...
The tumor-stroma ratio (TSR) has been reported as a strong, independent prognostic parameter in colon cancer well other epithelial types, and may be implemented to routine pathology diagnostics. TSR is an easy technique, based on hematoxylin eosin stained histological sections, estimating the amount of stroma present primary tumor. It links tumors with high stromal content poor prognosis. analysis time less than 2 min low inter-observer variation. Scoring validated number international...
This study investigated the predictive value of circulating microRNA-126 (cir-miRNA-126) in patients with metastatic colorectal cancer (mCRC) treated first-line chemotherapy combined bevacizumab. The included 68 patients. Blood samples (plasma) were collected before treatment initiation, at first clinical evaluation after 3 weeks and progression. Levels cir-miRNA-126 determined by qRT–PCR purification total RNA from plasma. Primary end points response rates evaluated according to Response...
Abstract The human transcription factor SOX4 was 5-fold up-regulated in bladder tumors compared with normal tissue based on whole-genome expression profiling of 166 clinical tumor samples and 27 urothelium samples. Using a SOX4-specific antibody, we found that the cancer cells expressed protein and, thus, did an evaluation 2,360 using microarray annotation. We correlation (P < 0.05) between strong increased patient survival. When overexpressed cell line HU609, strongly impaired...
The aim of this study was to identify deregulated transcription factors (TFs) in colorectal cancer (CRC) and evaluate their relation with the recurrence stage II CRC overall survival. Microarray-based transcript profiles 20 normal mucosas 424 samples were used 51 TFs displaying differential levels between mucosa CRC. For a subset these we provide vitro evidence that deregulation Wnt signalling pathway can lead alterations observed tissues. Furthermore, two independent cohorts...
High-risk patients with stage II colon cancer (CC) may benefit from adjuvant chemotherapy, but additional prognostic markers are needed for better stratification. We investigated the value of tumour stroma ratio (TSR) and budding (TB).A nationwide population-based cohort 573 CC was included. TSR scored on hematoxylin eosin sections as low (> 50% stroma) high (≤ stroma). TB evaluated in hotspots pan-cytokeratin stained 10 power fields (HPF) at invasive front classified by mean number buds per...
Purpose: In two previously published studies, associations with risk of radiation-induced subcutaneous fibrosis were found for single nucleotide polymorphisms (SNP) in TGFB1 (transforming growth factor beta 1 gene), XRCC1 (X-ray repair cross-complementing XRCC3 3 SOD2 (manganese superoxide dismutase gene) and ATM (gene ataxia telangiectasia mutated). The present study was conducted to seek a confirmation these findings.
This study investigated the clinical importance of linked angiogenetic biomarkers to chemotherapy, combined with anti-vascular endothelial growth factor A (anti-VEGF-A), as a first-line treatment in patients metastatic colorectal cancer (mCRC).A total 230 from randomised phase III were included. The primary microRNA-126 (pri-miRNA-126) A24G single-nucleotide polymorphism and mature miRNA-126 analysed by PCR using genomic DNA (full blood) formalin-fixed paraffin-embedded tissue sections,...
BACKGROUND: Additional prognostic markers are needed for better treatment stratification of stage II colon cancer (CC). We investigated the value tumor-infiltrating lymphocytes (TILs) in a true population-based cohort patients with CC. MATERIAL AND METHODS: A total 573 were included. Tumor blocks representing deepest invasive part primary tumor used analysis. CD3+ and CD8+ TILs at front evaluated by immunohistochemistry on whole sections. The area was manually outlined, Visiopharm Integrator...
Angiogenesis is a complex process involved in the proliferation and metastasis of malignant tumours, partly triggered by secretion various angiogenic factors tumour cells or stromal environment. We investigated correlation between bone marrow angiogenesis, estimated as microvessel density (MVD), interleukin-6 (IL-6), basic fibroblastic growth factor (bFGF), hepatocyte (HGF) syndecan-1 67 patients with newly diagnosed multiple myeloma, evaluated prognostic value these parameters. Circulating...
SUMMARY The application of assumption‐free, unbiased stereological techniques for estimation the volume‐weighted mean nuclear volume, v̄ V , from vertical sections benign and malignant aggregates in melanocytic skin tumours is described. Combining sampling nuclei with uniform probability a physical disector Cavalieri's direct estimator unbiased, number‐weighted N same populations also estimated. Having obtained estimates volume both volume‐and number distribution detailed investigation size...
The majority of microsatellite instable (MSI) colorectal cancers are sporadic, but a subset belongs to the syndrome hereditary nonpolyposis cancer (HNPCC). Microsatellite instability is caused by dysfunction mismatch repair (MMR) system that leads mutator phenotype, and MSI correlated prognosis response chemotherapy. Gene expression signatures as predictive markers being developed for many cancers, identification signature MMR deficiency would be interest both clinically biologically. To...
Introduction. The tissue microarray (TMA) technique comprises the potential of significantly reducing time and spent on slicing performing immunohistochemical (IHC) stainings paraffin-embedded tumor tissue. Tissue heterogeneity is an argument against using TMAs, which has been dealt with by increasing size number cores punched from each tumor. No consensus exists most optimal size, number, position TMA in donor paraffin block no information exist regarding agreement between two different...
Microarray analysis on pooled samples has previously identified ZDHHC9 (DHHC9) to be upregulated in colon adenocarcinoma compared normal mucosa. Analyses of 168 from proximal and distal adenocarcinomas using U133plus2.0 microarrays validated these findings, showing a significant two-fold (log 2) upregulation DHHC9 transcript (P<10(-6)). The was more striking microsatellite stable (MSS), than instable (MSI), tumours. Genes known interact with as H-Ras or N-Ras did not show expression...