A5067080931- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Nonlinear Partial Differential Equations
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Neurofibromatosis and Schwannoma Cases
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Uterine Myomas and Treatments
- Bone Tumor Diagnosis and Treatments
- Statistical Methods and Inference
- Oral and Maxillofacial Pathology
- Advanced Mathematical Modeling in Engineering
- Mathematical Approximation and Integration
- Gene expression and cancer classification
- Cervical Cancer and HPV Research
- Medical Imaging and Pathology Studies
- Chromatin Remodeling and Cancer
- Differential Equations and Boundary Problems
- Pain Management and Opioid Use
The University of Texas MD Anderson Cancer Center
2013-2025
Oslo University Hospital
2017-2024
Mount Sinai Hospital
2016-2023
Mount Sinai Hospital
2018-2023
ORCID
2023
University of Toronto
2018-2022
Sinai Health System
2018-2022
Norwegian Institute of Public Health
2022
University of Oslo
2018-2022
University Health Network
2019
BCOR - CCNB3 sarcoma (BCS) is a recently defined genetic entity among undifferentiated round cell sarcomas, which was initially classified as and treated similarly to the Ewing (ES) family of tumors. In contrast ES, BCS shows consistent overexpression, preliminary evidence suggests that these tumors share morphologic features with other harboring alterations, including internal tandem duplication (ITD) BCOR-MAML3 . To further investigate pathologic features, clinical behavior, their...
Value-based health care has been proposed as a unifying force to drive improved outcomes and cost containment.To develop standard set of multidimensional patient-centered for tracking, comparing, improving localized prostate cancer (PCa) treatment value.We convened an international working group patients, registry experts, urologists, radiation oncologists review existing data practices.The defined recommended representing who should be tracked, what measured at time points, are necessary...
ABSTRACT Objective We aim to evaluate outcomes for patients with resectable SNMM treated in the immunotherapy era. Methods Thirty‐seven SNM were identified using our institutional database between 2016 and 2023. Results Patients receiving neoadjuvant Ipi/Nivo (46%, n = 17) more likely have disease involving sinuses and/or skull base (71% vs. 35%, p 0.05). The overall response rate was 24%. Two‐year LRFS from start of therapy 63%, end local 78%. PFS 49%. who received evidence ( 4, 24%) had...
ACTB-GLI1 fusions have been reported as the pathognomonic genetic abnormality defining an unusual subset of actin-positive, perivascular myoid tumors, known "pericytoma with t(7;12) translocation." In addition, GLI1 oncogenic activation through a related MALAT1-GLI1 gene fusion has recently in 2 unrelated gastric namely plexiform fibromyxoma and gastroblastoma. Triggered by unexpected targeted RNA-sequencing results detecting GLI1-related group malignant neoplasms round to epithelioid...
NUT midline carcinoma is an aggressive tumor that occurs mainly in the head and neck and, less frequently, mediastinum lung. Following identification of index case a NUTM1 fusion positive undifferentiated soft tissue tumor, we interrogated additional cases primary visceral tumors for abnormalities. Targeted next-generation sequencing was performed on RNA extracted from formalin-fixed paraffin-embedded tissue, results validated by fluorescence situ hybridization using custom bacterial...
Primary intraosseous rhabdomyosarcomas (RMSs) are extremely rare. Recently 2 studies reported 4 cases of primary RMS with EWSR1/FUS-TFCP2 gene fusions, associated somewhat conflicting histologic features, ranging from spindle to epithelioid. In this study we sought further investigate the pathologic and molecular abnormalities a larger group RMSs by combined approach using targeted RNA sequencing analysis fluorescence in situ hybridization (FISH). We identified 7 cases, 3 males females, all...
Abstract Introduction To examine the risk of Alzheimer's disease (AD) among cancer survivors in a national database. Methods Retrospective cohort 3,499,378 mostly male US veterans aged ≥65 years were followed between 1996 and 2011. We used Cox models to estimate AD alternative outcomes (non‐AD dementia, osteoarthritis, stroke, macular degeneration) with without history cancer. Results Survivors wide variety cancers had modestly lower risk, but increased outcomes. screened cancers, including...
Infantile fibrosarcomas (IFS) represent a distinct group of soft tissue tumors occurring in patients under 2 years age and most commonly involving the extremities. Most IFS show recurrent ETV6-NTRK3 gene fusions, sensitivity to chemotherapy, an overall favorable clinical outcome. However, outside these well-defined pathologic features, no studies have investigated lacking or with morphology resembling older children. This study was triggered by identification novel SEPT7-BRAF fusion...
ABSTRACT NTRK3 ‐rearranged tumors other than infantile fibrosarcomas (IFSs) harboring the canonical ETV6‐NTRK3 fusions are uncommon, and include mainly inflammatory myofibroblastic gastrointestinal stromal tumors. Herein, we describe an additional subset of seven sharing gene rearrangements. The cohort included five females two males (age range 1‐67 years). Tumors were located in extremities, trunk, retroperitoneum, or intra‐abdominal. In all tumors, fluorescence situ hybridization (FISH)...
A major breakthrough in the classification of soft tissue tumors has been recent identification NTRK-fusion related neoplasms which are amenable to highly effective targeted therapies. Despite these therapeutic opportunities, diagnostic challenges have emerged recognizing characterized by protein kinase fusions, as they associated with a wide morphologic spectrum, variable risk malignancy and rather nonspecific immunoprofile. As such, NTRK-related fusions may occur infantile fibrosarcoma,...
Uterine tumor resembling ovarian sex-cord (UTROSCT) is a rare and distinctive neoplasm of unclear histogenesis, uncertain malignant potential. These neoplasms morphologically resemble stromal tumors the ovary, possess polyphenotypic immunophenotype. Their molecular pathogenesis has yet to be elucidated; notably, however, lack alterations found in other uterine bearing sex-cord-like differentiation, such as endometrial sarcoma. Following identification an index patient with ESR1-NCOA3 fusion...
Salivary gland adenocarcinoma not otherwise specified (NOS) is a heterogenous group, likely containing distinct tumors yet characterized. A growing number of low to intermediate-grade salivary carcinomas are now known harbor tumor-specific gene fusions. On occasion, identifying novel fusion allows for recognition new tumor type, in addition representing potential diagnostic tool. We sought characterize distinctive that would previously have been regarded as NOS. the basis 5 morphologically...
Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive soft tissue sarcoma, characterized by a distinctive phenotype in densely sclerotic collagenous stroma, that shows frequent MUC4 immunoreactivity and recurrent gene fusions, often involving EWSR1 gene. A pathogenetic link with low-grade fibromyxoid sarcoma (LGFMS) has been suggested, due to cases hybrid morphology as well overlapping genetic signature. However, small subset of SEF negative for lacks the canonical / FUS rearrangements....
6006 Background: IMPT has unique biologic and physical properties compared with IMRT, limits radiation dose beyond the targeted tumor volumes, is a novel de-intensification strategy for management of head neck tumors. This study was designed to compare outcomes patients OPC after chemoradiation therapy (CRT) IMRT vs IMPT. Methods: multi-center, randomized, phase III non-inferiority trial Stage III/IV (AJCC 7 th ) squamous cell carcinoma stratified by human papillomavirus status, smoking...
Abstract Dermatofibrosarcoma protuberans is a locally aggressive superficial mesenchymal neoplasm. It typically occurs in adulthood, and has been reported to have slight male predilection. Tumors characteristic histopathologic appearance, including: storiform architecture, infiltrative “honeycomb” growth within subcutaneous adipose tissue, immunoreactivity for CD34. Virtually all molecularly characterized cases date found harbor COL1A1‐PDGFB fusion product. Following identification of an...
Ectomesenchymal chondromyxoid tumor is a rare and benign neoplasm with predilection for the anterior dorsal tongue. Despite morphologic heterogeneity, most cases are characterized by proliferation of bland spindle cells distinctive reticular growth pattern myxoid stroma. The immunophenotype these neoplasms likewise variable; express glial fibrillary acid protein S100 protein, inconsistent reports keratin myoid marker expression. molecular pathogenesis poorly understood; however, subset has...
Myoepithelial tumors (MET) represent a clinicopathologically heterogeneous group of tumors, ranging from benign to highly aggressive lesions. Although MET arising in soft tissue, bone, or viscera share morphologic and immunophenotypic overlap with their salivary gland cutaneous counterparts, there is still controversy regarding genetic relationship. Half tissue bone harbor EWSR1 FUS related fusions, while the skin often show PLAG1 HMGA2 gene rearrangements. Regardless site origin, gold...
Abstract Ductal carcinoma in situ (DCIS) is a non-invasive type of breast cancer with highly variable potential becoming invasive and affecting mortality. Currently, many patients DCIS are overtreated due to the lack specific biomarkers that distinguish low risk lesions from those higher progression. In this study, we analyzed 57 pure 313 cancers (IBC) different patients. Three levels genomic data were obtained; gene expression, DNA methylation, copy number. We performed subtype stratified...
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