A5023683369- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Amyotrophic Lateral Sclerosis Research
- Systemic Sclerosis and Related Diseases
- Cerebral Palsy and Movement Disorders
- Long-Term Effects of COVID-19
- Effects of Vibration on Health
- Stroke Rehabilitation and Recovery
- Stress Responses and Cortisol
- Balance, Gait, and Falls Prevention
- Mycobacterium research and diagnosis
- Diabetic Foot Ulcer Assessment and Management
- Tryptophan and brain disorders
- Transcranial Magnetic Stimulation Studies
- Muscle activation and electromyography studies
- Powdery Mildew Fungal Diseases
Aarhus University
2017-2025
Background: Potential supplemental disease-modifying and neuroprotective treatment strategies are warranted in multiple sclerosis (MS). Exercise is a promising non-pharmacological approach, an uninvestigated ‘window of opportunity’ exists early the disease course. Objective: To investigate effect exercise on relapse rate, global brain atrophy secondary magnetic resonance imaging (MRI) outcomes. Methods: This randomized controlled trial ( n = 84, duration <2 years) included 48 weeks...
Purpose: To investigate the effect of different types physical training on balance performance and whether improved correlates with walking performance.Methods: Forty eight participants chronic stroke were randomly assigned to aerobic cycle ergometer (AT-group), resistance lower extremities (RT-group), or sham upper (ST-group). Participants exercised 3 d/week for 12 weeks. Balance (Berg Scale), peak oxygen uptake rate, isometric knee extensor strength, maximal gait speed, 6 minute walk test...
Impairments across multiple domains are a disabling consequence of sclerosis (MS). Originating from preventive medical strategies, the "time matters"-perspective has become focal point when treating MS. In particular, early detection physical and cognitive deficits, along with deficits in patient-reported outcomes seems crucial to further optimize both pharmacological non-pharmacological MS treatment strategies. Therefore, this topical review investigates level impairments (physical...
Background Early identification of potential deficits is utmost importance as early diagnosis and treatment has been shown to be crucial reduce disease activity impact—leading the notion “Time matters” in multiple sclerosis (MS). Objective The aim present study was compare physical-, cognitive-, patient-reported outcomes phase MS patients with matched healthy controls (HC). Methods This cross-sectional included 84 course (≤2 years from diagnosis) age- sex-matched HC. All participants...
Abstract Neuroaxonal damage in multiple sclerosis (MS) results from an interplay of neurotoxic pathomechanisms combined with a reduced neuroprotective capacity neurons and glia to resist damage. Kynurenine pathway (KP) imbalance resembles some the molecular mechanisms central incompletely understood MS pathophysiology. To study role KP MS, we performed targeted metabolomics on serum samples 353 persons 111 healthy individuals, detected MS-specific differences concentrations most kynurenines....
Purpose Examine the association between physical activity and neuromuscular function in patients with multiple sclerosis when also considering disease severity.Methods 91 were enrolled. Assessments included by 7-day thigh-worn accelerometry, knee extensor dynamometry (maximal isometric muscle strength, rate of force development (0–50 ms)), 5× sit-to-stand, 2-min walk test, timed 25 ft test. Physical tertile comparisons along simple regressions (adjusting for age, gender, EDSS, time since...
Background Exercise positively affects multiple sclerosis (MS) symptoms, physiological systems, and potentially cognition. However, an uninvestigated “window of opportunity” exists for exercise therapy early in the disease. Objective This study presents secondary analyses from Early Multiple Sclerosis Study, aims to investigate efficacy on physical function, cognition, patient-reported measures disease fatigue impact course MS. Methods randomized controlled trial (n = 84, time since...
Background. Fatigue is one of the most frequent symptoms in persons with multiple sclerosis (MS). Distinction made between subjective perceptions fatigue and objective measures fatigability. Fatigability can be measured by different protocols. Yet no studies have compared isometric concentric contraction protocols lower extremities head-to-head. Therefore, purpose present study was to (1) compare 2 such head-to-head (2) investigate association fatigability evoked walking. Methods. A total 45...
Background: Inflammatory lesions and neurodegeneration lead to motor, cognitive sensory impairments in people with multiple sclerosis (MS). Accumulation of disability is at least partially due diminished capacity for neuroplasticity within the central nervous system. Aerobic exercise a potentially important intervention enhance since it causes upregulation neurotrophins enhances corticospinal excitability which can be probed using single-pulse Transcranial Magnetic Stimulation (TMS). Whether...
To provide a multimethodological validation of MFIS in compliance with the COnsensus-based Standards for selection health status Measurement INstruments (COSMIN) guidelines using Danish population patients Multiple Sclerosis (pwMS).Factor analytic and multidimensional Rasch methods were applied to investigate structural validity MFIS. We employed measurement bi-factor models address divergence convergence. McDonalds ω was used assess reliability. Cross-cultural nomological assessed relation...
Neurodegeneration is an inevitable consequence of multiple sclerosis (MS) leading to impaired neuromuscular function, especially the lower extremities. Whilst maximal muscle strength (or force; Fmax) most examined feature ability rapidly increase force (= rate development; RFD) appear be preferentially sensitive towards neurodegeneration and potentially also great importance for physical function. The purpose present study was comprehensively examine compare different outcome measures...
In the relapsing remitting type of multiple sclerosis (MS) reducing relapses and neurodegeneration is crucial in halting long-term impact disease. Medical disease-modifying treatments have proven effective, especially when introduced early disease course. However, patients still experience activity disability progression, therefore, supplemental treatment strategies are warranted. Exercise appear to be one most promising strategies, but a somewhat overlooked 'window opportunity' exist The...
Exercise as a subset of physical activity is cornerstone in the management multiple sclerosis (MS) based on its pleiotropic effects, but continued progression field requires better future designs and methodologies.This paper outlines work 'Study design methodology' group MoXFo (moving exercise research forward) initiative, addresses critical aspects directions when defining question interest, subsequently, designing study intervention MS patients.The formation an international expert panel...
Motor fatigability (i.e. contraction-induced reduction in muscle strength) from a concentric task associate stronger to walking and perception of fatigue persons with multiple sclerosis (pwMS), compared an isometric task. However, the central peripheral contributions motor between these tasks have not been investigated.Compare knee extensors sustained protocol versus pwMS healthy controls (HCs).Participants (n=31 pwMS; n=15 HCs) underwent neuromuscular testing before immediately after two...
Falls as well fall-related injuries (e.g., bone fractures) are common in persons with multiple sclerosis (pwMS). Whilst some studies have identified lower extremity maximal muscle strength (Fmax) one among several risk factors, no previous investigated the association between rate of force development (RFD; ability to generate a rapid rise force) and falls pwMS. Not only is RFD substantially compromised (and more so than Fmax) pwMS, involving other neurodegenerative populations shown that -...
The prevalence of older (>60 years) people with multiple sclerosis (pwMS) is increasing. This introduces numerous challenges, as both MS and ageing independently contribute to the deterioration neuromuscular function.